Registration Dossier
Registration Dossier
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EC number: 226-408-0 | CAS number: 5395-50-6
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Standard Operation Procedure PCE/006/04 from GKA Analytik, BASF AG (chapter 4: visual method)
- Principles of method if other than guideline:
- The water solubility of substances with an expected high solubility are normally determined according to flask method described in "Annex Commission Directive 92/69/EEC, Part A.6", "OECD Guideline No. 105" and "U.S. EPA Product
Properties Test Guidelines OPPTS 830.7840". To apply this method, the preparation of a saturated solution of test item in water is required. Since the test item is already an aqueous solution, an home-made method described in the Standard
Operation Procedure PCE/006/04 from GKA Analytik, BASF AG (chapter 4: visual method) is applied to investigate complete miscibility. Regarding the "Data requirements for bioeidal product types FINAL DRAFT-Version 4.3.1 April 2000
(Chapter 2, Part A 3.5)", these experiments were carried out in dependence on the pH. Because of complete miseibility, the dependence on temperature is negligible and therefore not investigated. - GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- Tetrahydro-1,3,4,6-tetrakis(hydroxymethyl)imidazo[4,5-d]imidazole-2,5(1H,3H)-dione
- EC Number:
- 226-408-0
- EC Name:
- Tetrahydro-1,3,4,6-tetrakis(hydroxymethyl)imidazo[4,5-d]imidazole-2,5(1H,3H)-dione
- Cas Number:
- 5395-50-6
- Molecular formula:
- C8H14N4O6
- IUPAC Name:
- 1,3,4,6-tetrakis(hydroxymethyl)-octahydro-[1,3]diazolo[4,5-d]imidazole-2,5-dione
- Test material form:
- liquid
Constituent 1
Results and discussion
Water solubilityopen allclose all
- Key result
- Temp.:
- 20.3 °C
- pH:
- 5
- Remarks on result:
- completely miscible
- Key result
- Temp.:
- 20.3 °C
- pH:
- 7
- Remarks on result:
- completely miscible
- Key result
- Temp.:
- 20.3 °C
- pH:
- 9
- Remarks on result:
- completely miscible
Any other information on results incl. tables
Solubility in butter pH 5 and T (20.3°C ± 0.1°C)
mtest item [g] |
mbuffer [g] |
pH |
1.0 |
9.0 |
5.1 |
5.0 |
5.0 |
5.2 |
9.0 |
1.0 |
5.5 |
buffer |
|
5.0 |
All prepared mixtures were clear and homogeneous. The test item is miscible in buffer pH 5 at T = (20.3°C ± 0.1 °C) in any ratio.
Solubility in butter pH 7 and T (20.3°C ± 0.1°C)
mtest item [g] |
mbuffer [g] |
pH |
1.0 |
9.0 |
7.0 |
5.0 |
5.0 |
6.9 |
9.0 |
1.0 |
6.9 |
buffer |
|
7.0 |
All prepared mixtures were clear and homogeneousT. he test item is miscible in buffer pH 7 at T = (20.3°C ± 0.1 °C) in any ratio.
Solubility in butter pH 9 and T (20.3°C ± 0.1°C)
mtest item [g] |
mbuffer [g] |
pH |
1.0 |
9.0 |
8.5 |
5.0 |
5.0 |
7.6 |
9.0 |
1.0 |
6.5 |
buffer |
|
9.0 |
All prepared mixtures were clear and homogeneous. The test item is miscible in buffer pH 9 at T = (20.3°C ± 0.1 °C) in any ratio.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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