Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 222-307-0 | CAS number: 3414-63-9
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
DESCRIPTION OF FIRST AID MEASURES
Inhalation -
If inhaled, move to fresh air. If not breathing, give artificial and/or oxygen. Immediately notify medical personnel.
Skin contact -
Remove contaminated clothing. Wash exposed skin with soap and water for at least 15 minutes. Seek medical attention if sympotms occur and persist.
Eye contact -
Immediately wash with plenty of water, occasionally lifting the upper and lower eyelids. Continue for at least 15 minutes. Get medical attention if symptms occur and persist.
Ingestion -
If swallowed, wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Notify medical personnel.
MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED
To the best of our knowledge the toxicity of this substance has not been fully investigated, thus symptoms and effects are not fully known. Low exposure may cause hypertension, headache, nausea and vomiting. Overdose may cause severse hypertension, reflex bradycardia, marked increase in peripheral resistance and drcreased cardiac output. Other adverse effects cannot be excluded.
INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED
Treat symptomatically and supportively.
Inhalation -
If inhaled, move to fresh air. If not breathing, give artificial and/or oxygen. Immediately notify medical personnel.
Skin contact -
Remove contaminated clothing. Wash exposed skin with soap and water for at least 15 minutes. Seek medical attention if sympotms occur and persist.
Eye contact -
Immediately wash with plenty of water, occasionally lifting the upper and lower eyelids. Continue for at least 15 minutes. Get medical attention if symptms occur and persist.
Ingestion -
If swallowed, wash out mouth with water. Do not induce vomiting unless directed by medical personnel. Notify medical personnel.
MOST IMPORTANT SYMPTOMS AND EFFECTS, BOTH ACUTE AND DELAYED
To the best of our knowledge the toxicity of this substance has not been fully investigated, thus symptoms and effects are not fully known. Low exposure may cause hypertension, headache, nausea and vomiting. Overdose may cause severse hypertension, reflex bradycardia, marked increase in peripheral resistance and drcreased cardiac output. Other adverse effects cannot be excluded.
INDICATION OF ANY IMMEDIATE MEDICAL ATTENTION AND SPECIAL TREATMENT NEEDED
Treat symptomatically and supportively.
Fire-fighting measures
EXTINGUISHING MEDIA
- Suitable extinguishing media:
Use water spray, foam, dry powder or carbon dioxide as appropriate for surrounding fire and materials.
- Unsuitable extinguishing media:
No limitations given for this substance
SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE
Combustible, but not flammable. In case of fire toxic fumes of carbon monoxide (CO) and nitrogen oxides (NOx) may be emitted. High concentrations of finely divided airborne organic particles can potentially explode if ignited.
ADVICE FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Prevent fire-extinguishing water from contaminating the watercourses.
- Suitable extinguishing media:
Use water spray, foam, dry powder or carbon dioxide as appropriate for surrounding fire and materials.
- Unsuitable extinguishing media:
No limitations given for this substance
SPECIAL HAZARDS ARISING FROM THE SUBSTANCE OR MIXTURE
Combustible, but not flammable. In case of fire toxic fumes of carbon monoxide (CO) and nitrogen oxides (NOx) may be emitted. High concentrations of finely divided airborne organic particles can potentially explode if ignited.
ADVICE FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Prevent fire-extinguishing water from contaminating the watercourses.
Accidental release measures
PERSONAL PRECAUTIONS, PROTECTIVE EQUIPMENT AND EMERGENCY PROCEDURES
If the product is released or spilled, take proper precautions to minimize exposure by using appropriate personal protective equipment (see section Exposure controls / Personal protection). Avoid raising dust. The area should be adequately ventilated.
ENVIRONMENTAL PRECAUTIONS
Collect spillage and place in specific bins and send for destruction. Avoid release to drains.
METHODS AND MATERAIL FOR CONTAINMENT AND CLEANING UP
A small spill may be handled with water moistened disposable cloth and placed in container from chemical waste. A larger spill should be collected and placed in container for disposal. Use recommended personal protective equipment. Wash spill site with water after completed pick up.
If the product is released or spilled, take proper precautions to minimize exposure by using appropriate personal protective equipment (see section Exposure controls / Personal protection). Avoid raising dust. The area should be adequately ventilated.
ENVIRONMENTAL PRECAUTIONS
Collect spillage and place in specific bins and send for destruction. Avoid release to drains.
METHODS AND MATERAIL FOR CONTAINMENT AND CLEANING UP
A small spill may be handled with water moistened disposable cloth and placed in container from chemical waste. A larger spill should be collected and placed in container for disposal. Use recommended personal protective equipment. Wash spill site with water after completed pick up.
Handling and storage
PRECAUTIONS FOR SAFE HANDLING
Avoid dust generation and inhalation of dust. Avoid contact iwth eyes and skin. Ensure good ventilation. Use recommended personal protective equipment. A device for eyewash should be available. Use recommended personal protective equipment.
CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES
Store at regular indoor conditions, generally 15 to 25C, and keep the container tightly closed.
Avoid dust generation and inhalation of dust. Avoid contact iwth eyes and skin. Ensure good ventilation. Use recommended personal protective equipment. A device for eyewash should be available. Use recommended personal protective equipment.
CONDITIONS FOR SAFE STORAGE, INCLUDING ANY INCOMPATIBILITIES
Store at regular indoor conditions, generally 15 to 25C, and keep the container tightly closed.
Transport information
Land transport (UN RTDG/ADR/RID)
- UN number:
- 2811
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SpecialProvisionsopen allclose all
Inland waterway transport (UN RTDG/ADN(R))
- UN number:
- 2811
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Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
- UN number:
- 2811
Shipping information
- Proper shipping name and description:
- Toxic solid, Organic, N.O.S.
- Chemical name:
- Noradrenaline bitartrate
- Labels:
- 4.1(6.1)
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Air transport (UN RTDG/ICAO/IATA)
- UN number:
- 2811
Shipping information
- Proper shipping name and description:
- Toxic solid, Organic, N.O.S.
- Chemical name:
- Noradrenaline bitartrate
- Labels:
- 6.1
Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
CONTROL PARAMETERS
To the best of our knowledge, established occupational exposure limit value is not available for Noradrenaline,
Recommended Occupational Exposure Limit Value:
Substance Value Control Parameters Comments
Noradrenaline bitartrate 45µg/m3 LTEL 8h In-house limit
LTEL: Long-term exposure limit (8h TWA (time-weighted average))
EXPOSURE CONTROL
Appropriate engineering controls
Use appropriate controls (e.g. containment, local exhaust ventilation) as specified in a workplace risk assessment. Technical measures and appropriate operations should be given priority over the use of personal protective equipment. Handle in accordance with good industrial hygiene and safety practice.
PERSONAL PROTECTIVE EQUIPMENT
Eye face protection -
Wear safety glasses with side shields. An emergency eyewash station should be available.
Skin protection-
Handle with gloves. The sesected gloves must comply with the specifications in EC Directive 89/686/EEC and teh related standard EN374 or applicatble federal, state and national legislation.
Protective clothing-
Use impervious, disposable clothing to prevent skin contact. The type should be selected accordning to concentrations, quantities and duration of handling at the specific workplace.
Respiratory protection -
Required when dusts are generated. Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. Use air-purifying respirator with combination filters. In laboratories, use fume hood or dust control hood.
Environmetnal exposure controls-
Do not release into drains or water courses.
To the best of our knowledge, established occupational exposure limit value is not available for Noradrenaline,
Recommended Occupational Exposure Limit Value:
Substance Value Control Parameters Comments
Noradrenaline bitartrate 45µg/m3 LTEL 8h In-house limit
LTEL: Long-term exposure limit (8h TWA (time-weighted average))
EXPOSURE CONTROL
Appropriate engineering controls
Use appropriate controls (e.g. containment, local exhaust ventilation) as specified in a workplace risk assessment. Technical measures and appropriate operations should be given priority over the use of personal protective equipment. Handle in accordance with good industrial hygiene and safety practice.
PERSONAL PROTECTIVE EQUIPMENT
Eye face protection -
Wear safety glasses with side shields. An emergency eyewash station should be available.
Skin protection-
Handle with gloves. The sesected gloves must comply with the specifications in EC Directive 89/686/EEC and teh related standard EN374 or applicatble federal, state and national legislation.
Protective clothing-
Use impervious, disposable clothing to prevent skin contact. The type should be selected accordning to concentrations, quantities and duration of handling at the specific workplace.
Respiratory protection -
Required when dusts are generated. Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. Use air-purifying respirator with combination filters. In laboratories, use fume hood or dust control hood.
Environmetnal exposure controls-
Do not release into drains or water courses.
Stability and reactivity
Reactivity-
No known reactivity hazards under normal conditions
Chemical stability-
The substance is chemically stable at standard room temperature conditions, generally 15 to 25C
Possibility of hazardous reactions and conditions to avoid -
None known
Incompatible materials -
Strong oxidants; strong acids or bases
Hazardous decomposition products-
Carbon oxides (COx) and nitrogen oxides (NOx) may be formed
No known reactivity hazards under normal conditions
Chemical stability-
The substance is chemically stable at standard room temperature conditions, generally 15 to 25C
Possibility of hazardous reactions and conditions to avoid -
None known
Incompatible materials -
Strong oxidants; strong acids or bases
Hazardous decomposition products-
Carbon oxides (COx) and nitrogen oxides (NOx) may be formed
Disposal considerations
Waste treatment methods-
Dispose waste at authorized plant, in accordance with Directive 2008/98/EC and/or applicable federal, state, national or local legislation
Dispose waste at authorized plant, in accordance with Directive 2008/98/EC and/or applicable federal, state, national or local legislation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
