1-(3,5-dihydroxyphenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethan-1-one hydrobromide

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 Feb 2017 - 24 May 2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

27 Feb 2017 - 24 May 2018

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The Appearance/physical state and colour were sourced from the review of melting point test (as determined according to EC Methods A.1 and OECD Test Guidelines 102 (1995).

GLP compliance:

no

Physical state at 20°C and 1013 hPa:

solid

Remarks:

Based on the test item decomposing before melting at a tempreature of 215°C and as described in the study referred to.

Key result

Form:

solid: particulate/powder

Colour:

grey

Substance type:

organic

Conclusions:

The physical state and appearance of the test item is a grey solid/particulate at 20°C and 1013 hPa, based on the test item having no melting point and decomposes before melting at a tempereture of about 215°C, as described in the study referred to. The result is considered to be reliable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

1-(3,5-dihydroxyphenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethan-1-one hydrobromide

EC Number:

222-148-7

EC Name:

1-(3,5-dihydroxyphenyl)-2-[[2-(4-hydroxyphenyl)-1-methylethyl]amino]ethan-1-one hydrobromide

Cas Number:

3371-33-3

Molecular formula:

C17H19NO4.BrH

IUPAC Name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-hydroxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

Test material form:

solid: particulate/powder

Results and discussion

Melting / freezing point

Key result

Decomposition:

yes

Decomp. temp.:

215 °C

Any other information on results incl. tables

No melting point could be observed as the test item started to decompose at a temperature of 215 °C. The test item began to change its color from grey to black at about 215°C .

Applicant's summary and conclusion

Conclusions:

In the preliminary capillary test accoring to OECD guideline 102 and EC method A.1. no melting point could be observed as the test item started to decompose at a temperature of 215 °C. The test item began to change its color from grey to black at about 215 °C.