4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines.

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of 4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.

GLP compliance:

not specified

Type of method:

other: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014

Specific details on test material used for the study:

- Name of test material: C.I. Basic Violet 2 / (4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride)
- IUPAC name: 4-[(4-amino-3-methylphenyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline hydrochloride
- Molecular formula: C22H24ClN3
- Molecular weight: 365.906 g/mole
- Smiles :C(\c1cc(c(N)cc1)C)(c1cc(c(N)cc1)C)=C1\C=C(C(=[NH+])C=C1)C.[ClH-]
- Inchl: 1S/C22H23N3.ClH/c1-13-10-16(4-7-19(13)23)22(17-5-8-20(24)14(2)11-17)18-6-9-21(25)15(3)12-18;/h4-12,23H,24-25H2,1-3H3;1H
- Substance type: Organic
- Physical state: Dark green powder

Key result

Type:

pour density

Density:

0.541 g/cm³

Temp.:

24.4 °C

Remarks on result:

other: At 969.4 hPa pressure

Key result

Type:

tap density

Density:

0.69 g/cm³

Temp.:

24.4 °C

Remarks on result:

other: At 969.4 hPa pressure

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1st Reading	2nd Reading
Method	Test methods: Pour density and tapped density of powders recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	24.3°C	24.6°C
Atmospheric pressure (in hPa)	-	970.5	968.4
Weight of test item(m)		20.020	20.017
Volume of measuring cylinder; readability in g		50ml; 1 ml	50 ml; 1 ml
Volume of test item without tapping (V)		37	37
Volume of test item after tapping ( V1)	After 10 tapping	32	32
	After 50 tapping	30	30
	After 100 tapping	29	29
	After 250 tapping	29	29
	After 500 tapping	-	-
	After 750 tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

 

 

 

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

 

 

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	= m / V	0.5410	0.5410	0.5410
Tap density of test Item (g/cm³)	= m / V1	0.6903	0.6902	0.6902

 

 

Conclusions:

The pour density and tapped density of 4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride (CAS No. 3248-91-7) was determined to be 0.5410 g/cm³ and 0.6902 g/cm³ at 24.4 °C and 969.4 hPa.

Executive summary:

The density of test item 4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride (CAS No. 3248-91-7) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using graduated measuring cylinder. The pour density and tapped density of test item was determined to be 0.5410 g/cm³ and 0.6902 g/cm³ at 24.4 °C and 969.4 hPa.

Description of key information

The pour density and tapped density of 4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride (CAS No. 3248-91-7) was determined to be 0.5410 g/cm³ and 0.6902 g/cm³ at 24.4 °C and 969.4 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.692

Additional information

The density of test item 4-[(4-amino-m-tolyl)(4-imino-3-methylcyclohexa-2,5-dien-1-ylidene)methyl]-o-toluidine monohydrochloride (CAS No. 3248-91-7) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using graduated measuring cylinder. The pour density and tapped density of test item was determined to be 0.5410 g/cm³ and 0.6902 g/cm³ at 24.4 °C and 969.4 hPa.