Registration Dossier
Registration Dossier
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EC number: 219-006-1 | CAS number: 2312-35-8
Toxicity to terrestrial arthropods
Administrative data
Link to relevant study record(s)
Description of key information
96 hour LD50 47.92 µg/bee (contact), LD50 > 100 µg/L (bee); study conducted in accordance with EPPO Standard PP1/170(2); Kelly and Allan, 2002
Key value for chemical safety assessment
Additional information
The acute toxicity of propargite to the honeybee was determined in two acute toxicity studies. Both studies were performed to GLP with one study to an EPPO Standard and the other study to US EPA OPP 141 -1. The EPPO Standard is considered sufficiently acceptable to be considered as a 'standardised guideline' and so both studies have been assigned a reliability score of 1. As the EPPO Standard study covers both oral and contact toxicity, as opposed to just contact toxicity in the study using EPA OPP 141 -1, this study is considered to be the key study.
In the key study, the tests were performed in wire mesh cages. The test material was applied to the thorax of each bee (contact test) or administered to bees in sucrose solution (oral test). Observations were made up to 96 hours after applied or dosing and mortality assessed. For the contact toxicity, thirty bees (three replicates of ten) were exposed to 100, 50, 25, 12.5 and 6.25 µg/bee with water and acetone controls over 96 hours. The study was extended as mortality in the test material treatment groups increased by more than 10% over three consecutive 24 hour periods. The contact LD50 was estimated to be 47.92 µg/bee. For the oral toxicity, thirty bees (three replicates of ten) were exposed to 100 µg/bee administered in approximately 50% sucrose solution along with water and acetone controls for a period of 48 hours. No bees died following treatment and the oral LD50 is >100 µg/bee. Propargite is not considered harmful to bees by this route of exposure.
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