Registration Dossier
Registration Dossier
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EC number: 218-414-7 | CAS number: 2146-71-6
Endpoint summary
Administrative data
Description of key information
No signs of irritation or corrosion was found neither in the skin irritation test nor in the eye irritation test.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Three male Californian rabbits were trated in an acute skin irritation study according to OECD guideline 404 with 0.5 ml of vinyl laurate. The substance was administered semiocclusively on a shaved area of the back side using nontoxic tape for 4 hours and then washed with water. A shaved but untreated skin area of the same animals saved as control. A 14 days observation period followed. No signs of irritating effects according to the guideline scoring sceme were seen at any time in any animal. No other signs of toxicity were found. The body weight gain was in the expected range for untreated animals of this type of study.
Three male Californian rabbits were trated in an acute eye irritation study according to OECD guideline 405 with 0.1 ml of vinyl laurate. The untreated eye of the same animals saved as control. 24 hours after treatment the eyes were washed. A three days observation period followed. No signs of irritating effects according to the guideline scoring sceme were seen at any time in any animal. No other signs of toxicity were found. The body weight gain was in the expected range for untreated animals of this type of study.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
No signs of irritation was found neither in the skin irritation test nor in the eye irritation test.
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