Registration Dossier
Registration Dossier
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EC number: 217-121-1 | CAS number: 1745-89-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
4,4'-isopropylidenebis[2-allylphenol] TK 11907, was evaluated for genotoxic potential in the standard bacterial reverse mutation test, in the mammalian cell gene mutation in vitro as well as in the in vitro mammalian chromosomes aberration test. The results was negative in all three tests in vitro.
Justification for selection of genetic toxicity endpoint
All three existing in vitro studies are considered as key value for the chemical safety assessment.
Short description of key information:
4,4'-isopropylidenebis[2-allylphenol] TK 11907 was evaluated for genotoxic potential in the standard bacterial reverse mutation test, in the mammalian cell gene mutation in vitro as well as in the in vitro mammalian chromosomes aberration test. The results was negative in all three tests.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the above stated assessment of the genotoxic potential of 4,4'-isopropylidenebis[2-allylphenol] TK 11907,
(Ames test negative,in vitro mammalian cell gene mutation test negative, in vitro mammalian chromosomes aberration test negative), the substance is deemed non-genotoxic and accordingly does not need to be classified according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council)as implementation of UN-GHS in the EU.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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