Hydroxylapatite (Ca5(OH)(PO4)3)

Guidance on Safe Use

First-aid measures

General information:

Take note of the following instructions:

No special measures required.

· After skin contact: Wash with water.

· Most important symptoms and effects, both acute and delayed

No further relevant information available.

- Indication of any immediate medical attention and special treatment needed

No further relevant information available.

Fire-fighting measures

· Extinguishing media

· For safety reasons unsuitable extinguishing agents: No further relevant information available.

· Special hazards arising from the substance or mixture

No further relevant information available.

· Advice for firefighters

· Protective equipment: No special measures required.

Accidental release measures

·  Personal precautions, protective equipment and emergency procedures

Wear protective clothing.

· Environmental precautions:

Damp down dust with water spray.

Do not allow product to reach sewage system or any water course.

Inform respective authorities in case of seepage into water course or sewage system.

Do not allow to enter sewers/ surface or ground water.

·  Methods and material for containment and cleaning up: Pick up mechanically.

Handling and storage

· Precautions for safe handling

Keep receptacles tightly sealed.

Provide suction extractors if dust is formed.

Use appropriate industrial vacuum cleaners or central vacuum systems for dust removal.

Prevent static electric sparks.

No special measures required.

· Information about fire - and explosion protection: The product is not flammable.

· Conditions for safe storage, including any incompatibilities

· Storage:

· Requirements to be met by storerooms and receptacles: No special requirements.

· Further information about storage conditions: This product is hygroscopic.

· Specific end use(s) Not applicable.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

None

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

None

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

None

Shipping information

Proper shipping name and description:

None

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

None

Shipping information

Proper shipping name and description:

None

Special provisions / remarks

Remarks:

Environmental hazards: Not applicable.
Special precautions for user Not applicable.
Transport in bulk according to Annex II of Marpol and the IBC Code Not applicable.

Additional transport information

Additional information

Special provisions / remarks / other:

Not dangerous according to the above specifications.
GRACE recommendation for air transport: Cargo aircraft only.

Exposure controls / personal protection

Control parameters

· Ingredients with limit values that require monitoring at the workplace:

The product does not contain any relevant quantities of materials with critical values that have to be

monitored at the workplace.

· Additional information: Valid lists at time of creation were used as basis.

Appropriate engineering controls No further relevant information available.

· Personal protective equipment:

· General protective and hygienic measures:

The usual precautionary measures are to be adhered to when handling chemicals.

· Respiratory protection:

If the WEL value is exceeded.

Filter P2

Respiratory protection in case of dust.

· Protection of hands:

Wear gloves for protection against mechanical hazards according to EN 388.

Use gloves of stable material (e.g. Nitrile) - if necessary tri-coted to improve the wearability.

After use of gloves apply skin-cleaning agents and skin cosmetics.

Check the permeability prior to each anew use of the glove.

Protective gloves.

Check the condition of the gloves prior to each use.

The glove material has to be impermeable and resistant to the product/ the substance/ the preparation.

Selection of the glove material on consideration of the penetration times, rates of diffusion and the degradation.

Preventive skin protection by use of skin-protecting agents is recommended.

· Material of gloves

EN 388: Minimum requirements for efficiency level 1 for all groups.

Butyl rubber, BR

The selection of the suitable gloves does not only depend on the material, but also on further marks of quality and varies from manufacturer to manufacturer. As the product is a preparation of several substances, the resistance of the glove material can not be calculated in advance and has therefore to be checked prior to the application.

Recommended thickness of the material: 0.11 mm

· Penetration time of glove material

EN 420: Minimum requirements for efficiency level 1 for all groups.

The exact break through time has to be obtained from the manufacturer of the protective gloves

and has to be observed.

For the mixture of chemicals mentioned below the penetration time has to be at least 480 minutes

(Permeation according to EN 374 Part 3: Level 6).

· For the permanent contact in work areas without heightened risk of injury (e.g. Laboratory)

gloves made of the following material are suitable:

Butyl rubber, BR

Nitrile rubber, NBR

· For the permanent contact gloves made of the following materials are suitable:

Butyl rubber, BR

· Not suitable are gloves made of the following materials: cloth gloves

· Eye protection: Not required.

Stability and reactivity

· Reactivity No further relevant information available.

· Possibility of hazardous reactions No dangerous reactions known.

· Conditions to avoid No further relevant information available.

· Incompatible materials: Protect from contamination.

Hazardous decomposition products: Possible in traces.

Disposal considerations

Waste treatment methods

· Recommendation:

Disposal must be made according to official regulations.

Smaller quantities can be disposed of with household waste.

· Uncleaned packaging:

· Recommendation: Disposal must be made according to official regulations.