Registration Dossier
Registration Dossier
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EC number: 214-291-9 | CAS number: 1119-97-7
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Data on both C12 and C16 alkyltrimethylammonium bromide are used for
prediction of the toxicokinetics of the C14 alkyltrimethylammonium
bromide.
One study has examined the oral
absorption, distribution and excretion of cetrimonium bromide.
One study has examined the percutaneous absorption of
dodecyltrimethylammonium bromide in rats, in vivo.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 10
- Absorption rate - dermal (%):
- 10
Additional information
From a toxicokinetic study with oral gavage administration of radioactive cetrimonium bromide to rats, an oral absorption rate of 3 - 9% (average 6%) has been estimated. Radioactivity in tissues declined rapidly and no bioccumulation in tissues could be expected.
From dermal exposure of rats to radioactive dodecyltrimethylammonium bromide, the percutaneous absorption of the applied radioactivity was 3.15% corresponding to 28.4 ug/cm2.
These figures are far below default absorption rates of 100%, and thus, the available data indicate limited dermal and oral absorption of the substance. As a pragmatic approach an oral and dermal absorption rate of 10% will (if necessary) be used for the risk characterisation for systemic toxicity.
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