Registration Dossier
Registration Dossier
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EC number: 213-086-1 | CAS number: 923-02-4
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
N-methylol methacrylamide was hydrolysed only to a minor extent in simulated gastric fluid (pH 1.15) and simulated intestinal fluid (pH 7.5) within 4 hours at a temperature of 37 °C.
In simulated saliva (pH 9.0), the concentration of the substance decreased to 94 % within 4 hours, consequently, the hydrolysis product methacrylamide increased by almost the same amount.
Key value for chemical safety assessment
Additional information
N-methylol methacrylamide was hydrolysed only to a minor extent in simulated gastric fluid (pH 1.15) and simulated intestinal fluid (pH 7.5) within 4 hours at a temperature of 37 °C.
In simulated saliva (pH 9.0), the concentration of the substance decreased to 94 % within 4 hours, consequently, the hydrolysis product methacrylamide increased by almost the same amount.
The potential hydrolysis product methacrylic acid was not detectable with the HPLC method used.
There was no evidence for other hydrolysis products than formaldehyde and methacrylamide.
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