Registration Dossier
Registration Dossier
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EC number: 213-037-4 | CAS number: 918-04-7
Endpoint summary
Administrative data
Description of key information
An acute oral toxicity study in rats similar to OECD Guideline 401 is available (BASF SE, 1981). Male and female rats were treated with 2150, 2610, 3160, 3830, or 4640 mg/kg of the test substance via gavage and then observed for 14 days. Dyspnea, gasping, apathy, abnormal position, twitching, spastic gait, ruffled fur, ptosis, falling backwards and poor general state were observed as clinical signs. Animals that died showed lung congestion and passive hyperemia in the liver. No abnormalities were found in the surviving animals. The approximate LD50after 14 days was calculated to be 3402.0 mg/kg.
In an acute inhalation study (similar to OECD Guideline 403; BASF SE, 1981b), rats were exposed to dust-aerosols of the test material at a concentration of 5.78 mg/L for 4 hours. After the exposure period the animals were observed for 14 days. No mortality and no abnormalities in gross pathology were observed. There were no differences in body weight development between treated and control animals. Mild clinical signs (snout wiping during exposure, liquid up to reddened nasal secretion after exposure) were recorded, but the animals were without findings after one day. In conclusion, the LC50was >5.78 mg/L.
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Based on the available information, classification unter Regulation (EC) No 1272/2008 (CLP) for acute toxicity is not required.
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