Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Based on the publication from Thompson et al. (1981), DEC has the potential to cause genotoxic effects. The tests were performed prior to establishing the OECD guidelines. The tests would correspond to following OECD test guidelines: OECD 471 (AMES), OECD 476 (mouse lymphoma) and OECD 482 (rat hepatocytes). The (limited) experimental details which were provided indicate that DEC has the potential to cause genotoxic effects. Due to the limited details on experimental conditions and results including evaluation, the individual experiments were classified as Klimisch 2 (Ames and rat hepatocytes experiments) and Klimisch 3 (mouse lymphoma). The results of all tests indicate that DEC has the potential to cause genotoxic effects.

In the publication from Müller (1965, cited in Rédei 1982) the effect of DEC on the plant Arabinopsis thaliana were evaluated. According to Rédei, Müller reported not positive finding up to 500 mM. Since no details on experimental conditions, further results etc. were provided, this information was scored as Klimisch 4 information and was regarded as not relevant for classification and labelling.

For the risk assessment the information form Thompson et al. (1981) will be used. Beside the higher Klimisch scores, these results are more conservative and hence more protective.


Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

Since the mutagenicity experiments indicate genotoxic potential, classification is warranted.