Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-377-0 | CAS number: 811-97-2
Endpoint summary
Administrative data
Description of key information
In accordance with section 2 of REACH Annex XI, studies on skin and eye irritation do not need to be conducted as the substance is a gas.
When HFC 134a is in contact with cutaneous or ocular mucosal membranes, it causes slight irritation, which is possibly a physical consequence of the non-standard test procedures used, for example, freezing effects of vaporizing liquefied gas.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
In accordance with section 2 of REACH Annex XI, studies on skin and eye irritation do not need to be conducted as the substance is a gas.
In two studies in the rabbit, HFC 134a was judged to cause slight irritation to the skin and eye. These minimal effects were possibly a consequence of the test procedure, and may have resulted from local freezing effects of the vaporizing liquefied gas. Clinical observations during exposure of animals to vapour concentrations of up to 50000ppm in the two year study and much higher concentrations in acute studies did not show any respiratory or occular irritation.
Effects on skin irritation/corrosion: slightly irritating
Effects on eye irritation: slightly irritating
Justification for classification or non-classification
The gaseous state of HFC 134a precludes the conduct of conventional skin and eye irritation studies in animals. The effects observed in studies conducted under non-standard protocols for skin and eye irritation were minimal and possibly the result of local freezing effects. Very high single vapour exposures of HFC 134a and repeated exposures of up to 50000ppm for two years did not result in any occular or respiratory irritation. Therefore, classification for skin, eye and respiratory irritation is not warranted under EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
