2,2,2-trichloroethane-1,1-diol

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

pour density; tap density

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

GLP compliance:

no

Type of method:

other: pour and tap density method

Specific details on test material used for the study:

- Name of test material: 2,2,2-Trichloroethane-1,1-diol (Chloral hydrate)
- Molecular formula: C2-H3-Cl3-O2
- Molecular weight: 165.4026g/mol
- Smiles notation: C(C(O)O)(Cl)(Cl)Cl
- InChl: RNFNDJAIBTYOQL-UHFFFAOYSA-N
- Substance type: Organic
- Physical state: Solid

Key result

Type:

pour density

Density:

0.947 g/cm³

Temp.:

28.9 °C

Remarks on result:

other: Atmospheric pressure = 974.5hPa

Key result

Type:

tap density

Density:

0.967 g/cm³

Temp.:

28.9 °C

Remarks on result:

other: Atmospheric pressure = 974.5hPa

Observations:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1^stReading	2^ndReading
Method	Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]
Principle of method	The density is calculated from the difference in weight between the full and empty pycnometer and its volume.
Test temperature (°C)	-	29°C	28.9°C
Atmospheric pressure (in hPa)	-	974.5 hPa	974.6 hPa
Volume of test substance without tapping (V)		19.5 ml	23 ml
Volume of test substance after tapping (V1)		19.5 ml	22 ml

[1]The International Pharmacopoeiahttp://apps.who.int/phint/en/p/docf/anchor,get-started.html

CALCULATIONS:

Parameters	Details	Calculated values		Average Density
		1^stCalculation	2^ndCalculation
Pour Density of test substance (g/cm^3)	= m     v	1.025	0.8695	0.9472
Tap density of test substance (g/cm^3)	= m     v1	1.025	0.9090	0.9670

Conclusions:

The pour density and tapped density of 2,2,2-trichloroethane-1,1-diol CAS No. 302-17-0 was found to be 0.9472 g/cm3 and 0.9670 g/cm3 at 28.9 °C and 974.5hPa respectively.

Executive summary:

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be0.9472 gm/cm³and 0.9670 gm/cm³at 28.9 °C and 974.5 hPa.

Description of key information

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be 0.9472 g/cm3 and 0.9670 g/cm3 at 28.9 °C and 974.5 hPa. The value of density for chemical safety assessment was considered to be 0.9472 g/cm3

Key value for chemical safety assessment

Relative density at 20C:

0.947

Additional information

The density of test substance 2,2,2-trichloroethane-1,1-diol (CAS No. 302-17-0 ) was determined following OECD guideline 109 according to pour and tap density method. The pour density and tapped density of the test substance was found to be0.9472 g/cm³and 0.9670 g/cm³at 28.9 °C and 974.5 hPa.