Registration Dossier
Registration Dossier
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EC number: 205-613-9 | CAS number: 144-02-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Febr. 05, 2018 - Febr. 07, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- 9
- Conclusions:
- The log POW of barbital sodium was determined using the HPLC method according to OECD 117. The partitioning coefficient of the test item was stated as < 0.3 at pH 9.0 and at 25 ± 0.5 °C.
Reference
The correlation log K / log POW was used for the calculation of the log POW of the components of test item Barbital Sodium. Due to the fact that the calculated log POW of the peak was lower than the lowest log POW of the reference items (2-Butanone with log POW 0.3) the log POW of this peak is stated as < 0.3 at pH 9.0 and at 25±0.5 °C.
The validity criteria and results are presented in the following table:
Validity Criteria and Results
Parameter Criterion Found Assessment
Range (Max – Min. log POW) < 0.1 0.003 valid
Value within Range of Reference Items 0.30 - 2.70 -0.579 not valid*
* As the calculated log POW of the test item lies below the lowest log POW of the reference items (2-Butanone with log POW 0.3), the log POW is stated as < 0.3.
Description of key information
The log POW of barbital sodium was determined using the HPLC method according to OECD 117. The partitioning coefficient of the test item was stated as < 0.3 at pH 9.0 and at 25±0.5 °C.
Key value for chemical safety assessment
- at the temperature of:
- 25 °C
Additional information
As the calculated log POW of the peak lays below the lowest log POW of the reference items (2-Butanone with log POW 0.3), the log POW of the test item peak is stated as < 0.3.
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