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EC number: 204-976-0 | CAS number: 130-14-3
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- experimental data of read across substances
- Justification for type of information:
- Data for the target chemical is summarized based on the structurally similar read across chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- WoE report is based on two hydrolysis studies as- 1. and 2
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: sodium naphthalene-1-sulfonate
- Molecular formula: C10H7NaO3S
- Molecular weight: 230.218 g/mol
- Smiles notation: c12c(S(=O)(=O)[O-])cccc1cccc2.[Na+]
- InChl: 1S/C10H8O3S.Na/c11-14(12,13)10-7-3-5-8-4-1-2-6-9(8)10;/h1-7H,(H,11,12,13);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid - Radiolabelling:
- not specified
- Analytical monitoring:
- not specified
- Estimation method (if used):
- Structure estimation method
- Positive controls:
- not specified
- Negative controls:
- not specified
- Transformation products:
- not specified
- pH:
- 7
- DT50:
- 6 yr
- Type:
- second order
- Remarks on result:
- other: Hydrolysis rate constant is 0.038 L/mol-sec.
- pH:
- 8
- DT50:
- 211 d
- Type:
- second order
- Remarks on result:
- other: Hydrolysis rate constant is 0.038 L/mol-sec.
- pH:
- 7
- DT50:
- 5 yr
- Type:
- second order
- Remarks on result:
- other: Hydrolysis rate constant is 4.0 × 10-2L/mol-sec
- pH:
- 8
- DT50:
- 200
- Type:
- second order
- Remarks on result:
- other: Hydrolysis rate constant is 4.0 × 10-2L/mol-sec
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The hydrolysis half-life value of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) can be expected to be in range 5 -6 years at pH 7 and 200-211 days at pH 8 and Hydrolysis rate constant in range 0.038 L/mol-sec – 0.04 L/mol-sec. Based on these half-life values, it is concluded that the test chemical sodium naphthalene-1-sulfonate is not hydrolysable.
- Executive summary:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3).The studies are as mentioned below.
The first experimental study was reviewed from authoritative database (HSDB, 2018) in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-life of 6 yrs and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.
Next experimental study was also reviewed from authoritative database mentioned above in this study the base catalyzed second order hydrolysis rate constant was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) can be expected to be in range 5 -6 years at pH 7 and 200-211 days at pH 8 and Hydrolysis rate constant in range 0.038 L/mol-sec – 0.04 L/mol-sec. Based on these half-life values, it is concluded that the test chemical sodium naphthalene-1-sulfonate is not hydrolysable.
Reference
Description of key information
The hydrolysis half-life value of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) can be expected to be in range 5 -6 years at pH 7 and 200-211 days at pH 8 and Hydrolysis rate constant in range 0.038 L/mol-sec – 0.04 L/mol-sec. Based on these half-life values, it is concluded that the test chemical sodium naphthalene-1-sulfonate is not hydrolysable.
Key value for chemical safety assessment
Additional information
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3).The studies are as mentioned below.
The first experimental study was reviewed from authoritative database (HSDB, 2018) in this study the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-life of 6 yrs and 211 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that test chemical is not hydrolysable.
Next experimental study was also reviewed from authoritative database mentioned above in this study the base catalyzed second order hydrolysis rate constant was determined using a structure estimation method. The second order hydrolysis rate constant is determined to be 4.0 × 10-2L/mol-sec with a corresponding half lives of 5 years and 200 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical sodium naphthalene-1-sulfonate (CAS no. 130-14-3) can be expected to be in range 5 -6 years at pH 7 and 200-211 days at pH 8 and Hydrolysis rate constant in range 0.038 L/mol-sec – 0.04 L/mol-sec. Based on these half-life values, it is concluded that the test chemical sodium naphthalene-1-sulfonate is not hydrolysable.
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