Registration Dossier
Registration Dossier
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EC number: 204-598-6 | CAS number: 123-07-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Monitoring the Toxicity of Phenolic Chemicals to Activated Sludge Using a Novel Optical Scanning Respirometer
- Author:
- Chun-Man Chan, Waihung Lo, Kwok-Yin Wong, Wai-Fun Chung
- Year:
- 1 999
- Bibliographic source:
- Chun-Man Chan, Waihung Lo, Kwok-Yin Wong, Wai-Fun Chung, Monitoring the Toxicity of Phenolic Chemicals to Activated Sludge Using a Novel Optical Scanning Respirometer, Chemosphere, Vol 39 (9), pp 1421-1432, 1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test (Carbon and Ammonium Oxidation))
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- p-cresol
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- Activated Sludge was obtained from Shatin Sewage Treatment Works in Hong Kong.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- 439.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The activated sludge respiration inhibition by 4-methylphenol was determined as IC50 = 439.5 mg/L.
- Executive summary:
The activated sludge respiration inhibition by 4-methylphenol was determined as IC50 = 439.5 mg/L.
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