Registration Dossier
Registration Dossier
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EC number: 204-428-0 | CAS number: 120-82-1
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only abstract available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Title:
- Unnamed
Materials and methods
- Principles of method if other than guideline:
- Method: other: according to US EPA TSCA Health Effects Testing Guidelines 40 CFR 798.300
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2,4-trichlorobenzene
- EC Number:
- 204-428-0
- EC Name:
- 1,2,4-trichlorobenzene
- Cas Number:
- 120-82-1
- Molecular formula:
- C6H3Cl3
- IUPAC Name:
- 1,2,4-trichlorobenzene
- Details on test material:
- IUCLID4 Test substance: other TS: purity 98.9 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 104 weeks
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
150, 700, 3200 ppm
Basis:
- Control animals:
- yes, concurrent no treatment
- Details on study design:
- Post-exposure period: no
Results and discussion
Any other information on results incl. tables
RS-Freetext:
3200 ppm: mortality at week 104: male 45/50, female 50/50
3200 ppm: hepatocellular carcinomas (m: 50/50, f: 46/50) and
adenomas (m: 2/50, f: 8/50)
700 ppm: hepatocellular carcinomas (m: 27/50, f: 28/50) and
adenomas (m: 16/50, f: 16/50)
control: hepatocellular carcinomas (m: 8/49, f: 1/50) and
adenomas (m: 4/49, f: 3/50)
NOEL for carcinogenicity: 150 ppm
NOAEL for systemic toxicity: 150 ppm
see chapter 5.4
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
