Registration Dossier
Registration Dossier
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EC number: 204-398-9 | CAS number: 120-46-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
On the basis of the result, interpreted according to OECD 471:1997 and ISO 10993 -3, the test item "1,3 DYPHENYLPROPANE-1,3 -DIONE" tested as recommended by Standards, proved to be NOT MUTAGENIC for all the test strains, either in the presence or absence of metabolic activation.
According to OECD 476:1997 “In Vitro Mammalian Cell Gene Mutation Test”, under the test conditions applied, the test substance 1,3-Dyphenylpropane-1,3-Dione batch n°131211-E is considered to induce gene mutations in the cultured mammalian cells used.
According to OECD 487:2010 In vitro mammalian micronucleus test. Under the test condition 24 hours –S9 the test substance induced chromosome breakage loss at a concentration of 7,67 μg/ml, in cultured mammalian cells.
Endpoint Conclusion: Adverse effect observed (positive)
Justification for classification or non-classification
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