Registration Dossier
Registration Dossier
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EC number: 203-813-0 | CAS number: 110-89-4
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The NOEC (reproduction) for Daphnia magna is supposed to be >1.0 mg/L based on a read-across approach.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Remarks:
- Reproduction
- Effect concentration:
- 3.8 mg/L
Additional information
The 21-d NOEC (reproduction) for aquatic invertebrates was determined to be 3.8 mg/L (Daphnia magna, OECD 211, GLP; BASF, 2013). The effect values are related to nominal concentrations, due to the uncertainties regarding the applied analytical method. Nevertheless, the study can be used for the assessment of piperidine since the test solutions were freshly prepared every day to have a continuously guarenteed exposure. Moreover, the test was performed in a closed system. To support the key study, three long-term toxicity studies with Daphnia magna and structurally similar substances were used for a read-across approach (OECD 211, GLP-guideline studies) All studies were performed with analytical verification of test item concentrations.
- Ethylpiperidine (CAS 766-09-6): 21-d NOEC (repro) = 2.2 mg/L (BASF SE, 2013, 51E0721/11E121)
- Morpholine (CAS 110-91-8): 21-d NOEC (repro) = 5 mg/L (NITE, 1997, 91768)
- Piperazine (CAS 110-85-0): 21-d NOEC (immob. neonates) = 12.5 mg/L (AkzoNobel/Thomas et al., 2002)
Based on this data, the 21-d NOEC of 3.8 mg/L determined for piperidine seems to be reliable even with some analytical uncertainties in the test.
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