Registration Dossier
Registration Dossier
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EC number: 203-778-1 | CAS number: 110-56-5
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987-12-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN-Draft 38412 Part 12
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,4-dichlorobutane
- EC Number:
- 203-778-1
- EC Name:
- 1,4-dichlorobutane
- Cas Number:
- 110-56-5
- Molecular formula:
- C4H8Cl2
- IUPAC Name:
- 1,4-dichlorobutane
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test organisms
- Test organisms (species):
- activated sludge
Study design
- Limit test:
- no
- Total exposure duration:
- 24 h
Test conditions
- Details on test conditions:
- not specified
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC10
- Effect conc.:
- 56 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 181 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Details on results:
- 288 mg DOC/L = 762 mg product/L with a stirring time of 2 h.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- An EC50 of 181 mg/L and an EC10 of 56 mg/L have been found in a bacteria respiration inhibition test according to DIN 38412 part 12.
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