Registration Dossier
Registration Dossier
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EC number: 203-551-7 | CAS number: 108-11-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 337 mg/L
Additional information
MIBC was reported to have a 96 hour EC50 of 337 mg/L, with a 95% confidence interval of 324 -351 mg/L in Daphnia magna. The 48 -hour NOEC was 288 mg/L and was determined based on biological interpretation of the data and the highest exposure level exhibiting no Daphnia immobility. The study was conducted according to OECD Guideline 202 with no exceptions, as well as EPA OTS 797.1300 with no exceptions. An additional study was identified that assessed the acute toxicity of MIBC in Daphnia magna. The study did not follow GLP and was rated ‘2’ for reliability under Klimisch standards; however, the guidelines set forth in ISO 6341 (1982) was followed, and the study methodology satisfies the validity criteria of the most recent OECD 202. The study was conducted to determine the effect of the substance on the mobility of Daphnia magna after 24 h treatment. MIBC was dissolved in water at a final concentration of 1 %. Daphnia was bred in reconstituted water and fed algae (Scenedesmus subspicatus). For the duration of the test, pH was 8.18 and O2 was 8.7 mg/L. Immobilization in the controls was 5%. The EC50(24 h) of the reference substance (potassium dichromate) was 0.95 mg/L.
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