Registration Dossier
Registration Dossier
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EC number: 203-040-9 | CAS number: 102-56-7
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity according to a guideline similar OECD 401: LD50: 578 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 578 mg/kg bw
Additional information
Testing for acute oral toxicity according to a guideline similar OECD 401 revealed an LD50 value of 578 mg/kg bw. Although based on the chemical structure MetHb forming properties are not unlikely, no definite signs for a relevant MetHb formation or MetHb caused lethality were observed in this study. Thus the oral LD50 value of 578 mg/kg bw. is adequate for direct comparison with classification criteria.
On the other hand human experience shows that methaemoglobinaemia might occure after accidental exposure.
Justification for classification or non-classification
Based on the available data Met-Hb formation in humans is suspected after exposure. Since systemic availability for all three exposure routs is not unlikely a precautionary classification as R20/21/22 or Cat 4, H302/H312/H332 irrespective of the routs tested is warranted.
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