2-amino-4-nitrophenol

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

for read across substance

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxicity study of microorganism for the test chemical :
1) The toxicity of test material was evaluated for test material
2)The effect of test material evaluated for microorganisms

Test organisms (species):

other: 1.Pseudomonas putida 2. Photobacterium phosphoreum

Test type:

static

Water media type:

not specified

Limit test:

no

Total exposure duration:

16 h

Reference substance (positive control):

not specified

Duration:

16 h

Dose descriptor:

EC0

Effect conc.:

7 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Duration:

30 min

Dose descriptor:

EC50

Effect conc.:

29 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

other: bioiluminance

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical is likely to be toxic to microorganism atleast in the concentration range of 7 - 29 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l

Description of key information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:

29 mg/L

Additional information

Toxicity to microorganism:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Acute toxicity of test material was evaluated for microorganisms, the test material showed no effect on Pseudomonas putida when tested for 16 h at concentration 7 mg/l.

In another study , the effect of test material was evaluated on microorganism Photobacterium phosphoreum for 30 min inhibition of bioluminance test  the EC50 was obseved to be 29 mg/l. The test chemical  is  likely to be toxic to microorganism atleast in the concentration  range of 7 - 29 mg/l