Registration Dossier
Registration Dossier
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EC number: 202-640-8 | CAS number: 98-13-5
Endpoint summary
Administrative data
Description of key information
No acute toxicity studies are available which meet current guideline requirements. However, further testing is not required as the substance is corrosive. Summary data which pre-dates GLP and OECD test guidlines report an oral LD50 of 2.4 g/kg in rats and a dermal LD50 of 0.9 ml/kg in rabbits (Mellon, 1951). Based on a relative density of 1.25, the LD50 (dermal) is 1125 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 400 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 125 mg/kg bw
Additional information
No acute toxicity studies are available that meet current guideline requirements, therefore no key studies could be identified. Further testing is not required, however, as trichloro(phenyl)silane is corrosive. Reliability 4 summary data have been used for the purposes of classification and labelling.
Justification for classification or non-classification
Based on the available supporting data for acute oral and dermal toxicity, it is proposed that trichloro(phenyl)silane should be classified as R21 "Harmful in contact with skin" according to the criteria of EU Directive 67/548/EEC, and Acute Toxic 4 (dermal) under Regulation 1272/2008.
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