Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 3.1
GLP compliance:
no
Type of study:
mouse local lymph node assay (LLNA)
Species:
human
Strain:
not specified
Sex:
male/female
Route:
epicutaneous, open
Vehicle:
no data
Route:
other: no data
Vehicle:
no data
Vehicle:
not specified
No. of animals per dose:
6-10
Parameter:
SI
Remarks on result:
other: EC3 = Strong sensitization in human
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: Positive





The prediction was based on dataset comprised from the following descriptors: EC3
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain  logical expression:Result: In Domain

((((((("a" and "b" )  and "c" )  and "d" )  and "e" )  and "f" )  and "g" )  and ("h" and "i" )  )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Group 14 - Carbon C AND Group 15 - Nitrogen N AND Group 16 - Oxygen O by Chemical elements

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Bioavailable by Lipinski Rule Oasis

Domain logical expression index: "c"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=10%,
Dice(Atom centered fragments)

Domain logical expression index: "d"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=20%,
Dice(Atom centered fragments)

Domain logical expression index: "e"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=30%,
Dice(Atom centered fragments)

Domain logical expression index: "f"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=40%,
Dice(Atom centered fragments)

Domain logical expression index: "g"

Similarity boundary:Target: C(=O)(O)c1c(O)ccc(N(=O)=O)c1
Threshold=50%,
Dice(Atom centered fragments)

Domain logical expression index: "h"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.638

Domain logical expression index: "i"

Parametric boundary:The target chemical should have a value of log Kow which is <= 2.7

Interpretation of results:
sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In vivo LLNA study on human for skin sensitisation with 5-nitrosalicylic acid exhibits positive (stronge sensitizer) skin sensitisation results.
Executive summary:

In vivo LLNA study on human for skin sensitisation with 5-nitrosalicylic acid exhibits positive (stronge sensitizer) skin sensitisation results.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Skin sensitisation

In vivo LLNA study on mouse for skin sensitisation with 5-nitrosalicylic acid exhibits positive (stronge sensitizer) skin sensitisation results.

Migrated from Short description of key information:

The test substance 5-nitrosalicylic acid was predicted as being sensitizing to the skin of mouse.

Justification for selection of skin sensitisation endpoint:

In vivo LLNA study on mouse for skin sensitisation with 5-nitrosalicylic acid exhibits positive (stronge sensitizer) skin sensitisation results.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The test substance 5-nitrosalicylic acid is considered as sensitising for the purpose of classification.