Registration Dossier
Registration Dossier
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EC number: 202-506-9 | CAS number: 96-45-7
Immunotoxicity
Administrative data
- Endpoint:
- immunotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in Japanese.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of ethylenethiourea on the functions of mouse lymphocytes.
- Author:
- Teshima R, Ikebuchi H and Terao T.
- Year:
- 1 982
- Bibliographic source:
- Eisei Skikensho Hokoku 100: 44-48
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Imidazolidine-2-thione
- EC Number:
- 202-506-9
- EC Name:
- Imidazolidine-2-thione
- Cas Number:
- 96-45-7
- Molecular formula:
- C3H6N2S
- IUPAC Name:
- imidazolidine-2-thione
- Details on test material:
- Other name : Ethylenethiourea (ETU)
Constituent 1
Test animals
- Species:
- mouse
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
460 mg/kg
Basis:
Results and discussion
Results of examinations
- Details on results:
- Ethylenethiourea suppressed the primary and secondary immune response in mice and to a lesser extent also inhibited the primary immune response mitogen-stimulated lymphocyte proliferation in vitro. Studies in T cells revealed that ethylenethiourea suppressed the activity of both helper T cells and suppressor T cells.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
