Registration Dossier
Registration Dossier
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EC number: 202-473-0 | CAS number: 96-05-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No scientific well documented study is available for allyl methacrylate. In a biodegradation study ready biodegradation without bacteriotoxic effects at 100 mg/L were reported. Read across to the structural analogue methyl methacrylate was done instead. For methyl methacrylate, the inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate concentrations. Thus a NOEC of 100 mg/L was used for risk assessment.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
A weight of evidence approach is used for this endpoint. Data from the structural analogue, methyl methacrylate, was used together with data from biodegradation studies with allyl methacrylate. Both substances have very similar structural formulas and show similar physical/chemical, toxicological and ecotoxicological values. In addition behaviour in water (hydrolysis etc.) will result in very similar hydrolysis products.
Biodegradation data with the test substance allyl methacrylate at concentration of 100 mg/L show ready biodegradation. No toxic effects to the activated sludge were reported (see IUCLID section 5.2.1, MITI test).
Methyl methacrylate was non-toxic to activated sludge in a test for ready biodegradability according to the modified MITI (I) protocol. 96 % biodegradation were achieved within 14 d, indicating the absence of toxicity up to 100 mg/L (LGU, 2003). This is consistent with other microbial toxicity test results (Bringmann, 1988).
One study with limited reliability on the acute toxicity of allyl methacrylate to Pseudomonas putida is available. However, only limited information on the study performance is available. The test followed guideline DIN 38412, part 8 but the cell density was lower than recommended by the guideline. Based on the bacterial growth within 72 hours of exposure to allyl methacrylate an EC10 of 136 mg/L based on the nominal test concentration was determined (Roehm GmbH, 1988).
The results revealing more or less the same concentration range for effects and thus support the weight of evidence approach.
For risk assessment a worst case NOEC of 100 mg/L was used.
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