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EC number: 202-468-3 | CAS number: 95-96-5
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Water solubility:
- 16.3 g/L
- Temp.:
- 20.1 °C
- pH:
- 1.5
- Details on results:
- The results for the samples taken at 1, 2, 4, 24 and 48 hours showed, that concentration of the degradation product increased in time whereas concentration of DD-lactide remained stable over the first 24 hours. This indicates equilibrium between degradation and dissolution over this time period. At 48 hours no DD-lactide was detected. This was due to the fact that all DD-lactide had dissolved and degraded somewhere between 24 and 48 hours.
- Conclusions:
- D-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 ± 0.6 °C in the presence of excess undissolved D-lactide, was determined to be 16.3 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
- Executive summary:
In this study the water solubility of D-lactide was determined in accordance with OECD guideline 105. D-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 ± 0.6 °C in the presence of excess undissolved D-lactide, was determined to be 16.3 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
This information is used in a read-across approach in the assessment of the target substance. For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
- Endpoint:
- water solubility
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Water solubility:
- 16.7 g/L
- Temp.:
- 20.1 °C
- pH:
- ca. 2
- Details on results:
- The results for the samples taken at 1, 2, 4, 6.5, 24 and 48 hours show, that concentration of the degradation product increased in time whereas concentration of LL Lactide remained stable over the first 24 hours. This indicates equilibrium between degradation and dissolving over this time period.
The significatly lower concentration at t= 48 hours was due to the fact that LL Lactide had dissolved somewhere between t=24 and t=48 hours and that most part had degraded. - Conclusions:
- L-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 °C ± 0.6 °C in the presence of excess undissolved L-lactide, was determined to be 16.7 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
- Executive summary:
In this study the water solubility of L-lactide (100%) was determined in accordance to OECD TG 105. L-lactide degrades rapidly in water. Water solubility of this test substance at 20.1 °C ± 0.6 °C in the presence of excess undissolved L-lactide, was determined to be 16.7 g/L. The pH of the aqueous sample after 24 hours of stirring was 1.5.
Referenceopen allclose all
| Table 1: Water solubility of the test substance | |||
| Stirring time | Analysed [C] | Mean [C] | pH |
| [h] | [g/L] | [g/L] 1 | |
| 1 | 16.7 | 16.3 | 2.1 |
| 2 | 17.3 | 2.0 | |
| 4 | 16.3 | 1.9 | |
| 6 | 15.3 | 1.8 | |
| 24 | 15.7 | 1.5 | |
| 48 | n.d. | 1.3 | |
1: mean of all concentrations over the first 24 hours
n.d.= not detected
| Table 1: Main study- water solubility of the test substance | |||
| Stirring time | Analysed [C] | Mean [C] | pH |
| [h] | [g/L] | [g/L] 1 | |
| 1 | 17.2 | 16.7 | 2.2 |
| 2 | 17.8 | 2.1 | |
| 4 | 16.1 | 2 | |
| 6.5 | 16 | 1.8 | |
| 24 | 16.5 | 1.5 | |
| 48 | 1.3 | 1.3 | |
1: mean of all concentrations over the first 24 hours
- time point 6 hours not determined due to a dilution error
Description of key information
Water solubility was determined for L-lactide and D-lactide. The outcome was similar for the two lactides and is fully valid for dilactide as dilactide is a mixture of D- and L-lactide isomers. Lactides degrade rapidly in water. Water solubility of the test substance at 20.1 ± 0.6 °C in the presence of excess undissolved lactide was determined to be 16.3-16.7 g/L.
Key value for chemical safety assessment
- Water solubility:
- 16.3 g/L
- at the temperature of:
- 20 °C
Additional information
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