Veratrole

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 26 april 2012 to 12 october 2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study, OECD 104 compliant.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2012

Report date:

2012

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

11 april 2011

Type of method:

static method

Test material

Test material information

Constituent 1

Reference substance name:

Veratrole

EC Number:

202-045-3

EC Name:

Veratrole

Cas Number:

91-16-7

Molecular formula:

C8H10O2

IUPAC Name:

1,2-dimethoxybenzene

Test material form:

solid: crystalline

Results and discussion

Vapour pressure

Vapour pressure 1

Temp.:

20 °C

Vapour pressure:

73 Pa

Vapour pressure 2

Temp.:

25 °C

Vapour pressure:

96 Pa

Any other information on results incl. tables

Measurement Values Vapour Pressure Determination

 

1. Determination increasing temperature		2. Determination decreasing temperature
Temp. in °C	Pressure in mbar	Temp. in °C	Pressure in mbar
20.0	0.8	54.7	4.2
30.2	1.2	45.6	2.8
40.3	2.1	35.6	1.7
50.0	3.3	24.9	1.0
62.0	5.8	14.6	0.5

 

From the measured values for the increasing and for the decreasing temperature, log P (in log Pa) and 1/T (in 1/K) were calculated. The measured and the calculated values were plotted (p against T and log P against 1/T).

The regression curve with slope B. intercept A and correlation r was calculated (graph log P vs. 1/T). From the values of these parameters, vapour pressures at 20.0 and at 25.0 °C were calculated using the following equation:

logP = B*(1/T)+A => P(20°C)= 10E(B*(1/293.15)+A) and P(25°C)= 10E(B*(1/298.15)+A)

The calculation results are presented in the following table:

Calculated values for 1/T and log (P)

n	Temperature T	Pressure P	Temperature T	1/T	log P
	°C	mbar = hPa	K	1/K	log Pa
1	20.0	0.8	293.15	0.00341122	1.9031
2	30.2	1.2	303.35	0.00329652	2.0792
3	40.3	2.1	313.45	0.00319030	2.3222
4	50.0	3.3	323.15	0.00309454	2.5185
5	62.0	5.8	335.15	0.00298374	2.7634
6	54.7	4.2	327.85	0.00305018	2.6232
7	45.6	2.8	318.75	0.00313725	2.4472
8	35.6	1.7	308.75	0.00323887	2.2304
9	24.9	1.0	298.05	0.00335514	2.0000
10	14.6	0.5	287.75	0.00347524	1.6990

 

Calculated Values for vapour pressure

Parameter	Value	Unit
Vapour Pressure (20 °C)	73	Pa
Vapour Pressure (25 °C)	96	Pa

 

Applicant's summary and conclusion

Conclusions:

The vapour pressure of Veratrole was 73 Pa at 20°C and 96 Pa at 25°C.

Executive summary:

In a study (Henke W, 2012), the vapour pressure of Veratrole was determined using the static method and following the OECD guideline 104, under GLP conditions.

The vapour pressure of Veratrole was 73 Pa at 20°C and 96 Pa at 25°C, showing a low volatility.