3-amino-5-hydroxynaphthalene-2,7-disulphonic acid

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from Danish QSAR Database.

Qualifier:

according to guideline

Guideline:

other: estimated data

Principles of method if other than guideline:

Determination of estimated 96 hrs LC50 value of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. It is a continuous (Q)SAR model based on structural features and numeric molecular descriptors.

GLP compliance:

no

Specific details on test material used for the study:

- Name of the test material: 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid
- IUPAC name: 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid
- Molecular formula: C10H9NO7S2
- Molecular weight: 319.3131 g/mol
- Substance type: Organic
- Smiles: c1c2cc(c(cc2c(cc1S(=O)(=O)O)O)N)S(=O)(=O)O
- Physical state: Solid (Light grey, to, Off-white) powder

Analytical monitoring:

not specified

Vehicle:

no

Test organisms (species):

other: Fathead minnow

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

107.51 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: not toxic

Conclusions:

The estimated 96 hrs EC50 value of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 107.51 mg/L. It can be concluded from the estimated value that the 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) is not toxic to aquatic environment and can be cosidered as "not classified" as per CLP regulation.

Executive summary:

The estimated 96 hrs EC50 value of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 107.51 mg/L. It can be concluded from the estimated value that the 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) is not toxic to aquatic environment and can be cosidered as "not classified" as per CLP regulation.

Description of key information

The estimated 96 hrs EC50 value of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 107.51 mg/L. It can be concluded from the estimated value that the 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) is not toxic to aquatic environment and can be cosidered as "not classified" as per CLP regulation.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

107.51 mg/L

Additional information

Following three studies for the target chemical includes predicted data from Authoritative database and OECD QSAR toolbox to conclude the

3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) toxicity extent towards the fish are summarized as below:

The estimated 96 hrs EC50 value of 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) on Fathead minnow by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database is 107.51 mg/L. It can be concluded from the estimated value that the 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) is not toxic to aquatic environment and can be cosidered as "not classified" as per CLP regulation.

Based on the prediction done using the OECD QSAR toolbox version 3.4 with log kow as the primary descriptor and considering the closest read across substances, the short term toxicity on fish predicted for 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4). Effect concentration i.e LC50 value estimated to be 109.58 mg/l for fish for 96 hrs duration. It can be concluded that the 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4) likely to be toxic to fish, hence it can be considered to be “not classified” as per the CLP classification criteria for aquatic environment.

The above predicted study is suoorted by the experimental result of read across Sulphanilic acid (CAS: 121-57-3) from Chemospheres 1994, suggests that short-term toxicity to fish test was carried out for to study the effect of Sulphanilic acid on aquatic environment.

When Sulphanilic acid is exposed to thePimephales promelas for 96 h under static condition. Mortality was considered for the measurement of effect in 50 % of population of fish. The Lethal concentration to 50% LC50 ofPimephales promelas at 96 h is 100.4 mg/L. It can be concluded from the value that the Sulphanilic acid is not toxic to the aquatic environment and can be considred as ‘not classified” as per CLP regulation.

Thus based on the effect concentrations which is in the range 100.4 mg/l to 109.58 mg/l give the conclusion that test substance 3-amino-5-hydroxynaphthalene-2,7-disulfonic acid (CAS: 90-40-4 ) was likely to be not toxic to fish at environmentally relevant concentrations and can be considered to be“not classified”as per the CLP classification criteria.