Methyl N-methylanthranilate

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Principles of method if other than guideline:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals.

GLP compliance:

no

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

3.084

Temp.:

25 °C

pH:

3.68

Remarks on result:

other: logKow was reported to be 3.0842 ± 0.012

Details on results:

The Partition coefficient (Pow) of the test chemical was determined to be 3.0842 ± 0.012 at 25°C

Result:

Test substance		K	LogK	Log Pow by Generalized Calibration Graph	Mean of logPow ± S.D
Tr1	2.07	1.2013	0.0797	3.0760	3.0842±0.012
Tr2	2.084	1.2162	0.0850	3.0924

Conclusions:

The partition coefficient(n-octanol/water) of test substance was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 3.0842 ± 0.012 at 25°C.

Executive summary:

The partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 4 mg of test item and diluted with ACN up to 10 ml. Thus, the test solution concentration was 450.4 mg/l. The pH of test substance was 3.68. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared .The reference substances were Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 4-Acetylpyridine, Diphenylamine, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene having Pow value ranging from 0.5 to 4.6. The Log Pow value of the test chemical was determined to be 3.0842 ± 0.012 dimensionless at 25°C. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Description of key information

Based on the available data from study report,the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 4 mg of test item and diluted with ACN up to 10 ml. Thus, the test solution concentration was 450.4 mg/l. The pH of test substance was 3.68. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared .The reference substances were Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 4-Acetylpyridine, Diphenylamine, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene having Pow value ranging from 0.5 to 4.6. The Log Pow value of the test chemical methyl-N-methylanthranilate was determined to be 3.0842 ± 0.012 dimensionless at 25°C. On the basis of this value, test chemical can be considered to be hydrophilic in nature.

Key value for chemical safety assessment

Log Kow (Log Pow):

3.08

at the temperature of:

25 °C

Additional information

Based on the available data in a key study from study report, the partition Coefficient n-octanol/water of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. A test item solution was prepared by accurately weighing 4 mg of test item and diluted with ACN up to 10 ml. Thus, the test solution concentration was 450.4 mg/l. The pH of test substance was 3.68. The reference substances were chosen according to functional similarity with the test substance and calibration graph was prepared .The reference substances were Benzene, Biphenyl, Methyl benzoate, Benzyl Benzoate, 4-Acetylpyridine, Diphenylamine, Toluene, Ethylbenzene, n-Butylbenzene, Naphthalene having Pow value ranging from 0.5 to 4.6. The Log Pow value of the test chemical methyl-N-methylanthranilate was determined to be 3.0842 ± 0.012 dimensionless at 25°C.

Additional study from peer reviewed journal, authoritative and modelling database indicates that the octanol water partition coefficient (log Pow) value of the test chemical was estimated to be 2.81.

Thus, based on the available information, the logPow valueof the test chemical ranges from 2.81 to 3.08, respectively. On the basis of this value, test chemical can be considered to behydrophilic in nature.