Registration Dossier
Registration Dossier
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EC number: 201-207-0 | CAS number: 79-43-6
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In the non-GLP study from Pinchasov and Jensen (1989), the effect of DCA on the food intake of broiler chicks was investigated for 24 hours after a single oral administration of 0, 100, 200, 300 and 600 mg/kg b.w (3 birds per group). In the highest test group the broiler chicks consumed 25% less food when compared to the control group. Birds in the 3 first dosage groups (100, 200, 300 mg/kg bw) took up ca. 10 % less feed.
This study reported no mortality at single doses up to 600 mg/kg bw. However, the food intake was reduced when compared to the control. Statistical analysis was not performed on the animal and dose level, therefore, it cannot be decided if the food intake at this treatment level was already statistically significantly different to the control. Statistical analysis was performed as regression analysis of the food intake versus the dosage. This correlation was found to be statistically significant (P=0.013).
The provided data indicate that oral administration of 100 to 600 mg/kg bw DCA resulted in a reduced food intake during the first 24 hours after administration. Since the test was performed only for 24 hours , recovery was not investigated.
The results of this test showed that a single administration of 600 mg/kg bw does apparently not result in mortality within 24 hours and the birds continued with food intake. Since this study was not performed according to any guideline it is considered that this test has only very limited relevance for the risk assessment of DCA.
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