Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-114-5 | CAS number: 78-40-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The toxicokinetics of triethyl phosphate and metabolism was studied in rats and mice after oral and i.p. application. The skin penetrating capacities of a series of organic phosphates were measured by using a skin model in which isolated anterior forearm stratum corneum conjunctum was used.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Triethyl phosphate is well absorbed in the gastrointerstinal tract. A dermal absorption in vivo seems possible as indicated in the in vivo and in vitro experiments, the inhalative absorption is less important.
Within 16 hours in rats and mice 90% of the oral or ip applied dose was excreted via urine and nearly 100% of the oral or ip applied dose were excreted within 96 hours via urine. Urine of rats and mice were examined for metabolites of 32P-triethylphosphate. 32P-triethylposphate was excreted by both species as 32-diethylphosphate. As a further metabolite S-ethylcysteine was found. In neither case the trialkyl-phosphate was excreted unchanged. The average maximum steady-state rate for triethyl phosphate of penetration through isolated human skin is 0.623 x 10² µmol/cm² per min.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
