Nicotine dihydrogen ditartrate

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

for read across

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two toxicity study of microorganism for the test chemical :
2. Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms.
3.Microtox test was performed on photobacterium

GLP compliance:

not specified

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

other: 2. Ruminococcus albus and Butyrivibrio fibrisolvens 3.Photobacterium

Test type:

static

Water media type:

freshwater

Total exposure duration:

5 min

Reference substance (positive control):

not specified

Dose descriptor:

IC50

Effect conc.:

100 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

growth inhibition

Remarks on result:

other: Growth inhibition were observed in Butyrivibrio fibrisolvens

Duration:

5 min

Dose descriptor:

EC50

Effect conc.:

37 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

other: Bioluminance

Remarks on result:

other: No other data

Validity criteria fulfilled:

not specified

Conclusions:

The test chemical ist likely to be toxic to microorganism atleast in the dose range of 37 - 100 mg/l

Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance , microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l

Description of key information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance ,microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:

37 mg/L

Additional information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance ,microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l