Summary of Classification and Labelling
Harmonised classification - Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation)
General Information
Index Number EC / List no. CAS Number International Chemical Identification
647-012-00-8 232-752-2 9014-01-1 subtilisin

ATP Inserted / Updated: CLP00
CLP Classification (Table 3)
Classification Labelling Specific Concentration limits, M-Factors, Acute Toxicity Estimates (ATE) Notes
Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Skin Irrit. 2 H315 H315 GHS08
GHS07
GHS05
Dgr
Eye Dam. 1 H318 H318
STOT SE 3 H335 H335
Resp. Sens. 1 H334 H334

Signal Words Pictograms
Danger
GHS08
Health hazard
GHS07
Exclamation mark
GHS05
Corrosion
Seveso III Data
Disclaimer: Please note that some of the substances covered by the Seveso Directive can belong to more than one Seveso categories. It will be up to the users to decide whether their substance or mixture fall in one or in more of these classification categories depending on the tonnage bands and the concentrations.
Please also note that ECHA is not an authority for the Seveso Directive and that the Seveso categorisation below is provided for information only. The Seveso III Directive (Directive 2012/18/EU repealing Directive 96/82/EC (Seveso II) from 1 June 2015) is the only authentic legal reference and that the information in this inventory does not constitute legal advice. For further information on Seveso, please ask your national authority.

Seveso Data
Seveso Substance Seveso Categories
No
Notified classification and labelling
General Information
EC / List no.
Name CAS Number
232-752-2 Subtilisin 9014-01-1

Notified classification and labelling according to CLP criteria
Classification Labelling Specific Concentration limits, M-Factors Notes Classification affected by Impurities / Additives

Additional Notified Information

Number of Notifiers

Joint Entries

Hazard Class and Category Code(s) Hazard Statement Code(s) Hazard Statement Code(s) Supplementary Hazard Statement Code(s) Pictograms, Signal Word Code(s)
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS05
GHS09
Dgr
M=1
State/Form
14 yes View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:Lung) (inhalation) H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 2 H411 H411
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
State/Form
1333 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (not specified) H335
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
State/Form
330 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS05
GHS09
Dgr
M=1
State/Form
87 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
Aquatic Acute 1 H400  
  H410
Aquatic Chronic 2 H411  
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS09
GHS05
Dgr
M=1
55 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
Aquatic Acute 1 H400 H400
  H315 Dgr
39 View details
  H318
  H334
  H335
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS09
GHS05
Dgr
38 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (lungs) H335
STOT SE 3 H335 (Lungs) H335
Aquatic Acute 1 H400  
  H410
Aquatic Chronic 2 H411  
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS09
GHS05
Dgr
M=1
37 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Respiratory tra...) H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 2 H411 H411
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
36 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:Not appli...) H335
STOT SE 3 H335 (Not applicable) H335
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS09
GHS05
Dgr
28 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:Respirato...) H335
Aquatic Acute 1 H400  
  H410
Aquatic Chronic 2 H411  
Skin Irrit. 2 H315 H315 GHS08
GHS07
GHS05
Dgr
27 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
STOT SE 3 H335 H335
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS09
GHS05
Dgr
22 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 1 H410 H410
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS09
GHS05
Dgr
13 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:respirato...) H335
Aquatic Acute 1 H400  
  H410
Aquatic Chronic 2 H411  
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS09
GHS05
Dgr
M=1
State/Form
9 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Aquatic Acute 1 H400 H400
  H315 GHS08
GHS05
Dgr
8 View details
  H318
  H334
  H335
Skin Irrit. 2 H315 H315 (H315) GHS07
GHS08
GHS05
Dgr
5 View details
Eye Dam. 1 H318 H318 (H318)
Resp. Sens. 1 H334 H334 (H334)
STOT SE 3 H335 (eyes, respirato...) H335 (H335)
STOT SE 3 H335 (other:eyes, res...) H335 (H335)
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
State/Form
4 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
State/Form
2 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (lungs) (inhalation) H335
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS05
GHS09
Dgr
2 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 2 H411 H411
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
GHS09
Dgr
1 View details
Eye Dam. 1 H318 H318
Acute Tox. 4 H332 H332
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Aquatic Acute 1 H400 H400
Skin Irrit. 2 H315 H315 GHS08
GHS07
GHS05
Dgr
State/Form
1 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:respirato...) H335
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
1 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Respiratory tra...) H335
STOT SE 3 H335 (other:Respirato...) H335
Skin Irrit. 2 H315 H315 GHS07
GHS08
GHS05
Dgr
State/Form
1 View details
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
  H335
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS09
GHS05
Dgr
M=1
1 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 2 H411 H411
Acute Tox. 4 H302 H302 GHS07
GHS08
GHS05
GHS09
Dgr
M=1
1 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (Respiratory Sys...) (inhalation) H335
Aquatic Acute 1 H400 H400
Aquatic Chronic 2 H411 H411
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS05
GHS09
Dgr
1 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:-) H335
STOT SE 3 H335 H335
Aquatic Chronic 2 H411 H411
Acute Tox. 4 H302 H302 GHS08
GHS07
GHS05
GHS09
Dgr
M=1
1 View details
Skin Irrit. 2 H315 H315
Eye Dam. 1 H318 H318
Resp. Sens. 1 H334 H334
STOT SE 3 H335 (other:Respirato...) H335
Aquatic Acute 1 H400  
  H410
Aquatic Chronic 2 H411  

Number of Aggregated Notifications: 27