carcinogens-mutagens-dir-2004-37

Carc and Muta Directive, Annex I - Substances, Mixtures & Processes

EU. Substances, Mixtures, Related Processes: Annex I & Art. 2, Dir 2004/37/EC (CMRD), as amended by Dir (EU) 2022/431, 16 March 2022

This list contains a non-exhaustive inventory of substances based on Art. 2 carcinogen, mutagen and reprotoxin (CMR) definitions and Annex I of the Carcinogens, Mutagens and Reprotoxins Directive (CMRD). Category 1A and 1B CMRs are derived from the CLP Regulation's Table 3 of Annex VI (1272/2008/EC). Employers are obligated to minimize worker exposure to these agents as far as possible, and must arrange for medical surveillance of workers exposed to these substances.


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Group members
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Name EC / List no. CAS no. Association
Dinoseb acetate 220-560-1 2813-95-8 Expert judgement
2-sec-butyl-4,6-dinitrophenol, compound with 2,2'-iminodiethanol (1:1) 258-532-6 53404-43-6 Expert judgement
Binapacryl 207-612-9 485-31-4 Expert judgement
Sodium 2-(1-methylpropyl)-4,6-dinitrophenolate 252-331-7 35040-03-0 Expert judgement
2-sec-butyl-4,6-dinitrophenol, compound with 1-aminopropan-2-ol (1:1) 275-931-0 71735-19-8 Expert judgement
2-sec-butyl-4,6-dinitrophenol, compound with 2,2',2''-nitrilotriethanol (1:1) 229-166-4 6420-47-9 Expert judgement
Ammonium 2-sec-butyl-4,6-dinitrophenolate 228-858-3 6365-83-9 Expert judgement