Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry.

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Showing 101 - 150 of 240 results.

Substance name	EC No.	CAS No.	Date of inclusion	Reason for inclusion	Decision
Benzyl butyl phthalate (BBP)	201-622-7	85-68-7	28-Oct-2008	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/67/2008	Details
Butyl 4-hydroxybenzoate	202-318-7	94-26-8	25-Jun-2020	Endocrine disrupting properties (Article 57(f) - human health)	D(2020)4578-DC	Details
Dicyclohexyl phthalate DCHP	201-545-9	84-61-7	27-Jun-2018	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2018/636 ED/61/2018	Details
Diisobutyl phthalate	201-553-2	84-69-5	13-Jan-2010	Toxic for reproduction (Article 57c) Endocrine disrupting properties (Article 57(f) - human health)	EU/2017/4462 ED/30/2017 ED/68/2009	Details
Isobutyl 4-hydroxybenzoate	224-208-8	4247-02-3	17-Jan-2023	Endocrine disrupting properties (Article 57(f) - human health)	D(2022)9120-DC	Details
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid, its salts and its acyl halides covering any of their individual isomers and combinations thereof show/hide ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate EC No.: - \| CAS No.: 62037-80-3 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionyl fluoride EC No.: 218-173-8 \| CAS No.: 2062-98-8 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid EC No.: 236-236-8 \| CAS No.: 13252-13-6 potassium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionate EC No.: 266-578-3 \| CAS No.: 67118-55-2 Propanoic acid, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-, (+)- EC No.: - \| CAS No.: 75579-39-4 Propanoic acid, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-, (-)- EC No.: - \| CAS No.: 75579-40-7	-	-	16-Jul-2019	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	ED/71/2019	Details
Melamine	203-615-4	108-78-1	17-Jan-2023	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
Perfluorobutane sulfonic acid (PFBS) and its salts show/hide Potassium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 249-616-3 \| CAS No.: 29420-49-3 Ammonium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonate EC No.: 269-513-7 \| CAS No.: 68259-10-9 magnesium perfluorobutanesulfonate EC No.: - \| CAS No.: 507453-86-3 lithium perfluorobutanesulfonate EC No.: - \| CAS No.: 131651-65-5 morpholinium perfluorobutanesulfonate EC No.: - \| CAS No.: 503155-89-3 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulphonic acid EC No.: 206-793-1 \| CAS No.: 375-73-5 tetrabutyl-phosphonium nonafluoro-butane-1-sulfonate EC No.: 444-440-5 \| CAS No.: 220689-12-3 dimethyl(phenyl)sulfanium perfluorobutanesulfonate EC No.: 452-310-4 \| CAS No.: 220133-51-7 1-(4-butoxy-1-naphthalenyl)tetrahydrothiophenium 1,1,2,2,3,3,4,4,4-nonafluoro-1-butanesulfonate EC No.: 468-770-4 \| CAS No.: - Triphenylsulfanium perfluorobutane sulfonate EC No.: 478-340-8 \| CAS No.: 144317-44-2 N,N,N-triethylethanaminium 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate EC No.: - \| CAS No.: 25628-08-4 bis(4-t-butylphenyl)iodonium perfluorobutanesulfonate EC No.: 432-660-4 \| CAS No.: 194999-85-4	-	-	16-Jan-2020	Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	ECHA_01_2020.pdf	Details
Perfluoroheptanoic acid and its salts show/hide Perfluoroheptanoic acid EC No.: 206-798-9 \| CAS No.: 375-85-9 Sodium perfluoroheptanoate EC No.: 243-518-4 \| CAS No.: 20109-59-5 Ammonium perfluoroheptanoate EC No.: 228-098-2 \| CAS No.: 6130-43-4 potassium perfluoroheptanoate EC No.: - \| CAS No.: 21049-36-5	-	-	17-Jan-2023	Toxic for reproduction (Article 57c) PBT (Article 57d) vPvB (Article 57e) Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health) Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)	D(2022)9120-DC	Details
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC)	219-514-3	2451-62-9	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
1,3,5-tris[(2S and 2R)-2,3-epoxypropyl]-1,3,5-triazine-2,4,6-(1H,3H,5H)-trione (β-TGIC) -	423-400-0	59653-74-6	18-Jun-2012	Mutagenic (Article 57b)	ED/87/2012	Details
2,4,6-tri-tert-butylphenol	211-989-5	732-26-3	23-Jan-2024	Toxic for reproduction (Article 57c) PBT (Article 57d)	D(2023)8585-DC	Details
2-(2H-benzotriazol-2-yl)-4,6-ditertpentylphenol (UV-328)	247-384-8	25973-55-1	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
2-benzotriazol-2-yl-4,6-di-tert-butylphenol (UV-320)	223-346-6	3846-71-7	17-Dec-2014	PBT (Article 57d) vPvB (Article 57e)	ED/108/2014	Details
Alkanes, C10-13, chloro (Short Chain Chlorinated Paraffins)	287-476-5	85535-84-8	28-Oct-2008	PBT (Article 57d) vPvB (Article 57e)	ED/67/2008	Details
Ammonium pentadecafluorooctanoate (APFO)	223-320-4	3825-26-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
Anthracene	204-371-1	120-12-7	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Benzo[ghi]perylene	205-883-8	191-24-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Bis(pentabromophenyl) ether (decabromodiphenyl ether) (DecaBDE)	214-604-9	1163-19-5	19-Dec-2012	PBT (Article 57d) vPvB (Article 57e)	ED/169/2012	Details
Bis(tributyltin) oxide (TBTO)	200-268-0	56-35-9	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Decamethylcyclopentasiloxane D5	208-764-9	541-02-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Dodecamethylcyclohexasiloxane D6	208-762-8	540-97-6	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Fluoranthene	205-912-4	206-44-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
Hexabromocyclododecane (HBCDD) and all major diastereoisomers identified show/hide 1,2,5,6,9,10-hexabromocyclododecane EC No.: 221-695-9 \| CAS No.: 3194-55-6 gamma-hexabromocyclododecane EC No.: - \| CAS No.: 134237-52-8 Hexabromocyclododecane EC No.: 247-148-4 \| CAS No.: 25637-99-4 alpha-hexabromocyclododecane EC No.: - \| CAS No.: 134237-50-6 beta-hexabromocyclododecane EC No.: - \| CAS No.: 134237-51-7	-	-	28-Oct-2008	PBT (Article 57d)	ED/67/2008	Details
Medium-chain chlorinated paraffins (MCCP) UVCB substances consisting of more than or equal to 80% linear chloroalkanes with carbon chain lengths within the range from C14 to C17 show/hide di-, tri- and tetrachlorotetradecane EC No.: - \| CAS No.: - Alkanes, C14-17, chloro EC No.: 287-477-0 \| CAS No.: 85535-85-9 Tetradecane, chloro derivs. EC No.: - \| CAS No.: 198840-65-2 Alkanes, C14-16, chloro EC No.: - \| CAS No.: 1372804-76-6	-	-	08-Jul-2021	PBT (Article 57d) vPvB (Article 57e)	D(2021)4569-DC	Details
Nonadecafluorodecanoic acid (PFDA) and its sodium and ammonium salts show/hide Nonadecafluorodecanoic acid EC No.: 206-400-3 \| CAS No.: 335-76-2 sodium nonadecafluorodecanoate EC No.: - \| CAS No.: 3830-45-3 Ammonium nonadecafluorodecanoate EC No.: 221-470-5 \| CAS No.: 3108-42-7	-	-	12-Jan-2017	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/01/2017	Details
Octamethylcyclotetrasiloxane D4	209-136-7	556-67-2	27-Jun-2018	PBT (Article 57d) vPvB (Article 57e)	ED/61/2018	Details
Pentadecafluorooctanoic acid (PFOA)	206-397-9	335-67-1	20-Jun-2013	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/69/2013	Details
Perfluorononan-1-oic-acid and its sodium and ammonium salts show/hide Ammonium salts of perfluorononan-1-oic-acid EC No.: - \| CAS No.: 4149-60-4 Perfluorononan-1-oic-acid EC No.: 206-801-3 \| CAS No.: 375-95-1 Sodium salts of perfluorononan-1-oic-acid EC No.: - \| CAS No.: 21049-39-8	-	-	17-Dec-2015	Toxic for reproduction (Article 57c) PBT (Article 57d)	ED/79/2015	Details
Pyrene	204-927-3	129-00-0	15-Jan-2019	PBT (Article 57d) vPvB (Article 57e)	ED/88/2018	Details
S-(tricyclo(5.2.1.0'2,6)deca-3-en-8(or 9)-yl O-(isopropyl or isobutyl or 2-ethylhexyl) O-(isopropyl or isobutyl or 2-ethylhexyl) phosphorodithioate X4261	401-850-9	255881-94-8	17-Jan-2022	PBT (Article 57d)	D(2021)10043-DC	Details
Benzene-1,2,4-tricarboxylic acid 1,2 anhydride trimellitic anhydride; TMA	209-008-0	552-30-7	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018 EU/2018/594	Details
Cyclohexane-1,2-dicarboxylic anhydride all possible combinations of the cis- and trans-isomers show/hide trans-cyclohexane-1,2-dicarboxylic anhydride EC No.: 238-009-9 \| CAS No.: 14166-21-3 Cyclohexane-1,2-dicarboxylic anhydride EC No.: 201-604-9 \| CAS No.: 85-42-7 cis-cyclohexane-1,2-dicarboxylic anhydride EC No.: 236-086-3 \| CAS No.: 13149-00-3	-	-	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Diazene-1,2-dicarboxamide (C,C'-azodi(formamide)) (ADCA)	204-650-8	123-77-3	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
Ethylenediamine EDA	203-468-6	107-15-3	27-Jun-2018	Respiratory sensitising properties (Article 57(f) - human health)	ED/61/2018	Details
glutaral	203-856-5	111-30-8	08-Jul-2021	Respiratory sensitising properties (Article 57(f) - human health)	D(2021)4569-DC	Details
Hexahydromethylphthalic anhydride including cis- and trans- stereo isomeric forms and all possible combinations of the isomers show/hide Hexahydro-1-methylphthalic anhydride EC No.: 256-356-4 \| CAS No.: 48122-14-1 Hexahydro-3-methylphthalic anhydride EC No.: 260-566-1 \| CAS No.: 57110-29-9 Hexahydromethylphthalic anhydride EC No.: 247-094-1 \| CAS No.: 25550-51-0 Hexahydro-4-methylphthalic anhydride EC No.: 243-072-0 \| CAS No.: 19438-60-9	-	-	19-Dec-2012	Respiratory sensitising properties (Article 57(f) - human health)	ED/169/2012	Details
1, 2-dimethoxyethane; ethylene glycol dimethyl ether (EGDME)	203-794-9	110-71-4	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
1,2-benzenedicarboxylic acid, di-C6-10-alkyl esters or mixed decyl and hexyl and octyl diesters with ≥ 0.3% of dihexyl phthalate (EC No. 201-559-5) show/hide 1,2-Benzenedicarboxylic acid, mixed decyl and hexyl and octyl diesters EC No.: 272-013-1 \| CAS No.: 68648-93-1 1,2-Benzenedicarboxylic acid, di-C6-10-alkyl esters EC No.: 271-094-0 \| CAS No.: 68515-51-5	-	-	15-Jun-2015	Toxic for reproduction (Article 57c)	ED/39/2015	Details
1,2-Benzenedicarboxylic acid, di-C6-8-branched alkyl esters, C7-rich	276-158-1	71888-89-6	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1,2-Benzenedicarboxylic acid, di-C7-11-branched and linear alkyl esters	271-084-6	68515-42-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1,2-Benzenedicarboxylic acid, dihexyl ester, branched and linear	271-093-5	68515-50-4	16-Jun-2014	Toxic for reproduction (Article 57c)	ED/49/2014	Details
1,2-Benzenedicarboxylic acid, dipentyl ester, branched and linear	284-032-2	84777-06-0	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1,2-bis(2-methoxyethoxy)ethane (TEGDME; triglyme)	203-977-3	112-49-2	18-Jun-2012	Toxic for reproduction (Article 57c)	ED/87/2012	Details
1,2-diethoxyethane	211-076-1	629-14-1	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1-bromopropane (n-propyl bromide)	203-445-0	106-94-5	19-Dec-2012	Toxic for reproduction (Article 57c)	ED/169/2012	Details
1-Methyl-2-pyrrolidone (NMP)	212-828-1	872-50-4	20-Jun-2011	Toxic for reproduction (Article 57c)	ED/31/2011	Details
1-vinylimidazole	214-012-0	1072-63-5	25-Jun-2020	Toxic for reproduction (Article 57c)	D(2020)4578-DC	Details
2,2-bis(4'-hydroxyphenyl)-4-methylpentane AP-5	401-720-1	6807-17-6	15-Jan-2019	Toxic for reproduction (Article 57c)	ED/88/2018	Details
2-(4-tert-butylbenzyl)propionaldehyde and its individual stereoisomers show/hide 2-(4-tert-butylbenzyl)propionaldehyde EC No.: 201-289-8 \| CAS No.: 80-54-6 (2S)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-30-2 (2R)-3-(4-tert-butylphenyl)-2-methylpropanal EC No.: - \| CAS No.: 75166-31-3	-	-	08-Jul-2021	Toxic for reproduction (Article 57c)	D(2021)4569-DC.pdf	Details

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Candidate List of substances of very high concern for Authorisation

Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

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