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Candidate List of substances of very high concern for Authorisation

(published in accordance with Article 59(10) of the REACH Regulation)

Candidate List of substances of very high concern for Authorisation

Notes:

  • Authentic version: Only the Candidate List published on this website is deemed authentic. Companies may have immediate legal obligations following the inclusion of a substance in the Candidate List on this website including in particular Articles 7, 31 and 33 of the REACH Regulation.
  • Numerical identifiers: Each candidate list entry covers both anhydrous and hydrated forms of a substance. The CAS number shown in an entry is typically for the anhydrous form. Hydrated forms of the substance identified by other CAS numbers are still within the scope of the entry.
  • Other numerical identifiers: For those entries with "-" in the EC number and CAS number columns, a non-exhaustive inventory of EC and/or CAS Registry numbers describing substances or groups of substances considered to fall within the scope of the Candidate List entry is included, where practicably possible. This information can be accessed through the "Details" button of the selected entry. 
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Date of inclusion:

Decision IUCLID dataset  
209-358-4
573-58-0
16/12/2013
Carcinogenic (Article 57a)
Details
with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)
209-218-2
561-41-1
18/06/2012
Carcinogenic (Article 57a)
Details
D4
209-136-7
556-67-2
27/06/2018
PBT (Article 57d)
vPvB (Article 57e)
Details
trimellitic anhydride; TMA
209-008-0
552-30-7
27/06/2018
Respiratory sensitising properties (Article 57(f) - human health)
Details
with ≥ 0.1% of Michler's ketone (EC No. 202-027-5) or Michler's base (EC No. 202-959-2)
208-953-6
548-62-9
18/06/2012
Carcinogenic (Article 57a)
Details
D5
208-764-9
541-02-6
27/06/2018
PBT (Article 57d)
vPvB (Article 57e)
Details
D6
208-762-8
540-97-6
27/06/2018
PBT (Article 57d)
vPvB (Article 57e)
Details
208-169-4
513-79-1
15/12/2010
Carcinogenic (Article 57a)
Toxic for reproduction (Article 57c)
Details
208-168-9
513-78-0
15/01/2018
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Specific target organ toxicity after repeated exposure (Article 57(f) - human health)
Details
206-803-4
376-06-7
19/12/2012
vPvB (Article 57e)
Details
206-397-9
335-67-1
20/06/2013
Toxic for reproduction (Article 57c)
PBT (Article 57d)
Details
206-203-2
307-55-1
19/12/2012
vPvB (Article 57e)
Details
206-114-9
302-01-2, 7803-57-8
20/06/2011
Carcinogenic (Article 57a)
Details
206-104-4
301-04-2
16/12/2013
Toxic for reproduction (Article 57c)
Details
205-923-4
218-01-9
15/01/2018
Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
Details
205-916-6
207-08-9
15/01/2019
Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
Details
205-912-4
206-44-0
15/01/2019
PBT (Article 57d)
vPvB (Article 57e)
Details
205-883-8
191-24-2
27/06/2018
PBT (Article 57d)
vPvB (Article 57e)
Details
205-426-2
140-66-9
19/12/2011
Endocrine disrupting properties (Article 57(f) - environment)
Details
205-017-9
131-18-0
20/06/2013
Toxic for reproduction (Article 57c)
Details
204-927-3
129-00-0
15/01/2019
PBT (Article 57d)
vPvB (Article 57e)
Details
204-826-4
127-19-5
19/12/2011
Toxic for reproduction (Article 57c)
Details
204-650-8
123-77-3
19/12/2012
Respiratory sensitising properties (Article 57(f) - human health)
Details
204-450-0
121-14-2
13/01/2010
Carcinogenic (Article 57a)
Details
204-419-1
120-71-8
19/12/2012
Carcinogenic (Article 57a)
Details
204-371-1
120-12-7
28/10/2008
PBT (Article 57d)
Details
204-212-6
117-82-8
19/12/2011
Toxic for reproduction (Article 57c)
Details
204-211-0
117-81-7
28/10/2008
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
Details
204-118-5
115-96-8
13/01/2010
Toxic for reproduction (Article 57c)
Details
203-977-3
112-49-2
18/06/2012
Toxic for reproduction (Article 57c)
Details
203-924-4
111-96-6
19/12/2011
Toxic for reproduction (Article 57c)
Details
203-839-2
111-15-9
20/06/2011
Toxic for reproduction (Article 57c)
Details
203-804-1
110-80-5
15/12/2010
Toxic for reproduction (Article 57c)
Details
203-794-9
110-71-4
18/06/2012
Toxic for reproduction (Article 57c)
Details
203-772-9
110-49-6
16/07/2019
Toxic for reproduction (Article 57c)
Details
203-727-3
110-00-9
19/12/2012
Carcinogenic (Article 57a)
Details
203-713-7
109-86-4
15/12/2010
Toxic for reproduction (Article 57c)
Details
EDA
203-468-6
107-15-3
27/06/2018
Respiratory sensitising properties (Article 57(f) - human health)
Details
203-458-1
107-06-2
19/12/2011
Carcinogenic (Article 57a)
Details
203-445-0
106-94-5
19/12/2012
Toxic for reproduction (Article 57c)
Details
202-974-4
101-77-9
28/10/2008
Carcinogenic (Article 57a)
Details
202-959-2
101-61-1
18/06/2012
Carcinogenic (Article 57a)
Details
202-918-9
101-14-4
19/12/2011
Carcinogenic (Article 57a)
Details
202-716-0
98-95-3
17/12/2015
Toxic for reproduction (Article 57c)
Details
202-679-0
98-54-4
16/07/2019
Endocrine disrupting properties (Article 57(f) - environment)
Details
202-591-2
97-56-3
19/12/2012
Carcinogenic (Article 57a)
Details
202-506-9
96-45-7
16/12/2013
Toxic for reproduction (Article 57c)
Details
202-486-1
96-18-4
20/06/2011
Carcinogenic (Article 57a)
Toxic for reproduction (Article 57c)
Details
202-453-1
95-80-7
19/12/2012
Carcinogenic (Article 57a)
Details
202-429-0
95-53-4
19/12/2012
Carcinogenic (Article 57a)
Details
202-177-1
92-67-1
19/12/2012
Carcinogenic (Article 57a)
Details
202-027-5
90-94-8
18/06/2012
Carcinogenic (Article 57a)
Details
201-963-1
90-04-0
19/12/2011
Carcinogenic (Article 57a)
Details
201-861-7
88-85-7
19/12/2012
Toxic for reproduction (Article 57c)
Details
201-622-7
85-68-7
28/10/2008
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
Details
201-581-5
85-01-8
15/01/2019
vPvB (Article 57e)
Details
201-559-5
84-75-3
16/12/2013
Toxic for reproduction (Article 57c)
Details
201-557-4
84-74-2
28/10/2008
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
Details
201-553-2
84-69-5
13/01/2010
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
Details
DCHP
201-545-9
84-61-7
27/06/2018
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - human health)
Details
201-329-4
81-15-2
28/10/2008
vPvB (Article 57e)
Details
201-280-9
80-46-6
12/01/2017
Endocrine disrupting properties (Article 57(f) - environment)
Details
Bisphenol A; BPA
201-245-8
80-05-7
12/01/2017
Toxic for reproduction (Article 57c)
Endocrine disrupting properties (Article 57(f) - environment)
Endocrine disrupting properties (Article 57(f) - human health)
Details
201-182-6
79-16-3
19/12/2012
Toxic for reproduction (Article 57c)
Details
201-173-7
79-06-1
30/03/2010
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
201-167-4
79-01-6
18/06/2010
Carcinogenic (Article 57a)
Details
201-075-4
78-00-2
19/12/2012
Toxic for reproduction (Article 57c)
Details
201-058-1
77-78-1
19/12/2012
Carcinogenic (Article 57a)
Details
201-004-7
77-09-8
19/12/2011
Carcinogenic (Article 57a)
Details
200-879-2
75-56-9
19/12/2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
200-842-0
75-12-7
18/06/2012
Toxic for reproduction (Article 57c)
Details
200-755-8
71-48-7
15/12/2010
Carcinogenic (Article 57a)
Toxic for reproduction (Article 57c)
Details
200-679-5
68-12-2
19/12/2012
Toxic for reproduction (Article 57c)
Details
200-589-6
64-67-5
19/12/2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
200-453-6
60-09-3
19/12/2012
Carcinogenic (Article 57a)
Details
200-280-6
56-55-3
15/01/2018
Carcinogenic (Article 57a)
PBT (Article 57d)
vPvB (Article 57e)
Details
200-268-0
56-35-9
28/10/2008
PBT (Article 57d)
Details
200-028-5
50-32-8
20/06/2016
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Toxic for reproduction (Article 57c)
PBT (Article 57d)
vPvB (Article 57e)
Details
are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium, silicon and zirconium are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm). c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight
-
-
19/12/2011
Carcinogenic (Article 57a)
Details
show/hide
tris(4-nonylphenyl, branched) phosphite EC No.: 701-028-2 | CAS No.: -
Phenol, 4-nonyl-, phosphite (3:1) EC No.: 608-492-4 | CAS No.: 3050-88-2
Tris(nonylphenyl) phosphite EC No.: 247-759-6 | CAS No.: 26523-78-4
-
-
16/07/2019
Endocrine disrupting properties (Article 57(f) - environment)
Details
show/hide
Perboric acid, sodium salt EC No.: 234-390-0 | CAS No.: 11138-47-9
Sodium perborate EC No.: 239-172-9 | CAS No.: 15120-21-5
-
-
16/06/2014
Toxic for reproduction (Article 57c)
Details
with ≥0.1% w/w 4-heptylphenol, branched and linear (4-HPbl)
-
-
15/01/2018
Endocrine disrupting properties (Article 57(f) - environment)
Details
-
-
17/12/2014
Toxic for reproduction (Article 57c)
Details
show/hide
Ammonium salts of perfluorononan-1-oic-acid EC No.: - | CAS No.: -, 4149-60-4
Perfluorononan-1-oic-acid EC No.: 206-801-3 | CAS No.: 375-95-1
Sodium salts of perfluorononan-1-oic-acid EC No.: - | CAS No.: -, 21049-39-8
-
-
17/12/2015
Toxic for reproduction (Article 57c)
PBT (Article 57d)
Details
PFHxS
show/hide
Ammonium perfluorohexane-1-sulphonate EC No.: 269-511-6 | CAS No.: 68259-08-5
Potassium perfluorohexane-1-sulphonate EC No.: 223-393-2 | CAS No.: 3871-99-6
Perfluorohexane-1-sulphonic acid EC No.: 206-587-1 | CAS No.: 355-46-4
-
-
07/07/2017
vPvB (Article 57e)
Details
show/hide
Decanoic acid, nonadecafluoro-, sodium salt EC No.: - | CAS No.: 3830-45-3
Ammonium nonadecafluorodecanoate EC No.: 221-470-5 | CAS No.: 3108-42-7
Nonadecafluorodecanoic acid EC No.: 206-400-3 | CAS No.: 335-76-2
-
-
12/01/2017
Toxic for reproduction (Article 57c)
PBT (Article 57d)
Details
including cis- and trans- stereo isomeric forms and all possible combinations of the isomers
show/hide
Hexahydro-4-methylphthalic anhydride EC No.: 243-072-0 | CAS No.: 19438-60-9
Hexahydro-3-methylphthalic anhydride EC No.: 260-566-1 | CAS No.: 57110-29-9
Hexahydro-1-methylphthalic anhydride EC No.: 256-356-4 | CAS No.: 48122-14-1
Hexahydromethylphthalic anhydride EC No.: 247-094-1 | CAS No.: 25550-51-0
-
-
19/12/2012
Respiratory sensitising properties (Article 57(f) - human health)




Details
and all major diastereoisomers identified
show/hide
Hexabromocyclododecane EC No.: 247-148-4 | CAS No.: 25637-99-4
gamma-hexabromocyclododecane EC No.: - | CAS No.: 134237-52-8
1,2,5,6,9,10-hexabromocyclododecane EC No.: 221-695-9 | CAS No.: 3194-55-6
alpha-hexabromocyclododecane EC No.: - | CAS No.: 134237-50-6
beta-hexabromocyclododecane EC No.: - | CAS No.: 134237-51-7
-
-
28/10/2008
PBT (Article 57d)





Details
all possible combinations of the cis- and trans-isomers
show/hide
trans-cyclohexane-1,2-dicarboxylic anhydride EC No.: 238-009-9 | CAS No.: 14166-21-3
cis-cyclohexane-1,2-dicarboxylic anhydride EC No.: 236-086-3 | CAS No.: 13149-00-3
Cyclohexane-1,2-dicarboxylic anhydride EC No.: 201-604-9 | CAS No.: 85-42-7
-
-
19/12/2012
Respiratory sensitising properties (Article 57(f) - human health)



Details
EC No. 233-139-2 and EC No. 234-343-4
show/hide
Boric acid, crude natural EC No.: 234-343-4 | CAS No.: 11113-50-1
Boric acid EC No.: 233-139-2 | CAS No.: 10043-35-3
-
-
18/06/2010
Toxic for reproduction (Article 57c)


Details
are fibres covered by index number 650-017-00-8 in Annex VI, part 3, table 3.1 of Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, and fulfil the three following conditions: a) oxides of aluminium and silicon are the main components present (in the fibres) within variable concentration ranges b) fibres have a length weighted geometric mean diameter less two standard geometric errors of 6 or less micrometres (µm) c) alkaline oxide and alkali earth oxide (Na2O+K2O+CaO+MgO+BaO) content less or equal to 18% by weight
-
-
19/12/2011
Carcinogenic (Article 57a)
Details
show/hide
Dichromic acid EC No.: 236-881-5 | CAS No.: 13530-68-2
Chromic acid EC No.: 231-801-5 | CAS No.: 7738-94-5
-
-
15/12/2010
Carcinogenic (Article 57a)


Details
covering any of the individual stereoisomers of [1] and [2] or any combination thereof
-
-
15/06/2015
vPvB (Article 57e)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, ethoxylated covering UVCB- and well-defined substances, polymers and homologues, which include any of the individual isomers and/or combinations thereof
show/hide
26-(4-nonylphenoxy)-3,6,9,12,15,18,21,24-Octaoxahexacosan-1-ol EC No.: 604-395-6 | CAS No.: 14409-72-4
2-[2-(4-nonylphenoxy)ethoxy]ethanol EC No.: 243-816-4 | CAS No.: 20427-84-3
Nonylphenol, branched, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-209-1 | CAS No.: 68412-54-4
4-Nonylphenol, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-045-0 | CAS No.: 26027-38-3
Nonylphenol, ethoxylated EC No.: 500-024-6 | CAS No.: 9016-45-9
Nonylphenol, ethoxylated (6,5-EO) (9016-45-9) EC No.: 931-753-1 | CAS No.: -
Nonylphenol, ethoxylated (15-EO) (9016-45-9) EC No.: 931-756-8 | CAS No.: -
Nonylphenol, ethoxylated (10-EO) (9016-45-9) EC No.: 931-755-2 | CAS No.: -
Nonylphenol, ethoxylated (8-EO) (9016-45-9) EC No.: 931-754-7 | CAS No.: -
2-[2-[2-[2-(4-nonylphenoxy)ethoxy]ethoxy]ethoxy]ethanol EC No.: 230-770-5 | CAS No.: 7311-27-5
20-(4-nonylphenoxy)-3,6,9,12,15,18-hexaoxaicosan-1-ol EC No.: 248-743-1 | CAS No.: 27942-27-4
Nonylphenol, ethoxylated (EO = 4) EC No.: 939-975-0 | CAS No.: -
Nonylphenol, ethoxylated (polymer) EC No.: 938-618-6 | CAS No.: -
2-{2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethoxy}ethanol EC No.: 687-833-9 | CAS No.: 1119449-38-5
2-[4-(3,6-dimethylheptan-3-yl)phenoxy]ethanol EC No.: 687-832-3 | CAS No.: 1119449-37-4
Nonylphenolpolyglycolether EC No.: 932-998-7 | CAS No.: -
Nonylphenol, ethoxylated (EO = 10) EC No.: 939-993-9 | CAS No.: -
Isononylphenol, ethoxylated EC No.: 609-346-2 | CAS No.: 37205-87-1
4-Nonylphenol, branched, ethoxylated
1 - 2.5 moles ethoxylated
EC No.: 500-315-8 | CAS No.: 127087-87-0
26-(nonylphenoxy)-3,6,9,12,15,18,21,24-octaoxahexacosan-1-ol EC No.: 247-816-5 | CAS No.: 26571-11-9
-
-
20/06/2013
Endocrine disrupting properties (Article 57(f) - environment)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 9 covalently bound in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof
show/hide
p-(1-methyloctyl)phenol EC No.: 241-427-4 | CAS No.: 17404-66-9
Phenol, 4-nonyl-, branched EC No.: 284-325-5 | CAS No.: 84852-15-3
4-(1-ethyl-1-methylhexyl)phenol EC No.: 257-907-1 | CAS No.: 52427-13-1
p-(1,1-dimethylheptyl)phenol EC No.: 250-339-5 | CAS No.: 30784-30-6
p-isononylphenol EC No.: 247-770-6 | CAS No.: 26543-97-5
p-nonylphenol EC No.: 203-199-4 | CAS No.: 104-40-5
4-(3,5-Dimethyl-3-heptyl)phenol EC No.: 635-389-1 | CAS No.: 186825-36-5
4-(3,6-Dimethyl-3-heptyl)phenol EC No.: 635-391-2 | CAS No.: 142731-63-3
Nonylphenol EC No.: 246-672-0 | CAS No.: 25154-52-3
Phenol, nonyl-, branched EC No.: 291-844-0 | CAS No.: 90481-04-2
4-(2,6-Dimethyl-2-heptyl)phenol EC No.: 635-388-6 | CAS No.: 521947-27-3
4-(3-ethylheptan-2-yl)phenol EC No.: 635-696-0 | CAS No.: 186825-39-8
Isononylphenol EC No.: 234-284-4 | CAS No.: 11066-49-2
-
-
19/12/2012
Endocrine disrupting properties (Article 57(f) - environment)
Details
substances with a linear and/or branched alkyl chain with a carbon number of 7 covalently bound predominantly in position 4 to phenol, covering also UVCB- and well-defined substances which include any of the individual isomers or a combination thereof
show/hide
4-heptylphenol EC No.: 217-862-0 | CAS No.: 1987-50-4
Phenol, heptyl derivs. EC No.: 276-743-1 | CAS No.: 72624-02-3
-
-
12/01/2017
Endocrine disrupting properties (Article 57(f) - environment)
Details
covering well-defined substances and UVCB substances, polymers and homologues
show/hide
2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol EC No.: 618-344-0 | CAS No.: 9002-93-1
4-tert-Octylphenol monoethoxylate EC No.: 621-345-9 | CAS No.: 2315-67-5
[No public or meaningful name is available] EC No.: 621-341-7 | CAS No.: 2315-61-9
-
-
19/12/2012
Endocrine disrupting properties (Article 57(f) - environment)
Details
show/hide
4,4'-oxydianiline EC No.: 202-977-0 | CAS No.: 101-80-4
-
-
19/12/2012
Carcinogenic (Article 57a)
Mutagenic (Article 57b)
Details
covering any of their individual isomers and combinations thereof
show/hide
Potassium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionate EC No.: 266-578-3 | CAS No.: 67118-55-2
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionic acid EC No.: 236-236-8 | CAS No.: 13252-13-6
2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propionyl fluoride EC No.: 218-173-8 | CAS No.: 2062-98-8
Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate EC No.: 700-242-3 | CAS No.: 62037-80-3
-
-
16/07/2019
Equivalent level of concern having probable serious effects to human health (Article 57(f) - human health)
Equivalent level of concern having probable serious effects to the environment (Article 57(f) - environment)
Details
covering any of its individual anti- and syn-isomers or any combination thereof
-
-
15/01/2018
vPvB (Article 57e)
Details

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