Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
432-240-0
CAS no.:
12056-51-8
Index number:
Molecular formula:
H3KOTi
SMILES:
O.[KH].[Ti]
InChI:
InChI=1S/K.H2O.Ti.H/h;1H2;;
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
10
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance is suspected of causing cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful if inhaled and may cause respiratory irritation.

Breakdown of all 147 C&L notifications submitted to ECHA

Carc. 2 H351 Harmonised Classification
STOT SE 3 H335
Acute Tox. 4 H332
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Suspected to be Carcinogenic (Harmonised C&L).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 7 active registrations under REACH, 1 Joint Submission(s) and 3 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000+ tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

Other release to the environment of this substance is likely to occur from: outdoor use and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting).

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and of articles where the substances are not intended to be released and where the conditions of use do not promote release. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).

This substance can be found in complex articles, with no release intended: vehicles and Vehicles (e.g. personal vehicles, delivery vans, boats, trains, metro or planes)).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and laboratory work.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use as processing aid and outdoor use as processing aid.

This substance is used in the following products: metals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), closed batch processing in synthesis or formulation, transfer of chemicals, the low energy manipulation of substances bound in materials or articles, laboratory work, handling of solid inorganic substances (e.g. ores and raw metal oxides, packaging/mixing/blending and weighing of metal powders) and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: of substances in closed systems with minimal release, in the production of articles and in processing aids at industrial sites.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; use only outdoors or in a well-ventilated area; obtain special instructions before use; use personal protective equipment as required.; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing.

Storage statements

Store this substance locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • COVANCE CRS SA 071, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain
  • ENVIGO CRS SAU 070, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • IMMI-TITAN S.R.L., Via Cesare Battisti, 8 20122 MILANO Italy
  • Morimura Bros. Europe B.V., Cannenburgerweg 59C 1244 RH Ankeveen Netherlands
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • Toho Titanium Europe Co.,Ltd., 2nd Floor, Bury House, 31 Bury Street EC3A 5AR London United Kingdom

Substance names and other identifiers

Potassium titanium oxide (K2Ti6O13)
C&L Inventory, Substance Evaluation - CoRAP
TXAX
REACH pre-registration
kaaliumtitaanoksiid (K2Ti6O13) (et)
C&L Inventory
kalij-titanov oksid (K2Ti6O13) (sl)
C&L Inventory
kalijev titanov oksid (K2Ti6O13) (hr)
C&L Inventory
kalio titano oksidas (K2Ti6O13) (lt)
C&L Inventory
kaliumtitaanioksidi (K2Ti6O13) (fi)
C&L Inventory
kaliumtitaanoxide (K2Ti6O13) (nl)
C&L Inventory
kaliumtitanat (sv)
C&L Inventory
kaliumtitanoksid (K2Ti6O13) (no)
C&L Inventory
kaliumtitanoxid (K2Ti6O13) (da)
C&L Inventory
kálium-titán-oxid (K2Ti6O13) (hu)
C&L Inventory
kālija titāna oksīds (K2Ti6O13) (lv)
C&L Inventory
ossido di potassio e titanio (K2Ti6O13) (it)
C&L Inventory
ossidu tat-titanju potassju (K2Ti6O13) (mt)
C&L Inventory
oxid de potasiu-titan (K2Ti6O13) (ro)
C&L Inventory
oxid didraselno-hexatitaničitý (K2Ti6O13) (sk)
C&L Inventory
oxyde de potassium et titane (K2Ti6O13) (fr)
C&L Inventory
Tlenek potasowo-tytanowy (K2Ti6O13) (pl)
C&L Inventory
tridekaoxid didraselno-hexatitaničitý(K2Ti6O13) (cs)
C&L Inventory
óxido de potasio y titanio (K2Ti6O13) (es)
C&L Inventory
óxido de potássio e titânio (K2Ti6O13) (pt)
C&L Inventory
οξείδιο του καλιοτιτανίου (K2Ti6O13) (el)
C&L Inventory
калиево-титаниев оксид (K2Ti6O13) (bg)
C&L Inventory
hydrate potassium hydride titanium
Other
Potassium hexatitanate
Registration dossier
Potassium Titanium Oxide
Registration dossier
TOFIX
Registration dossier
Potassium titanate GPL 325/200
Registration dossier
Potassium titanate PFF
Registration dossier
022-004-00-1
Index number
C&L Inventory
12056-51-8
CAS number
C&L Inventory, Substance Evaluation - CoRAP, Other
149202-13-1
Deleted CAS number
Other
39284-88-3
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 12 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Solid: particulate/powder (33%), Powder (33%), Other (33%) [3]
C Odour
Other (100%) [1]
C Substance type
Inorganic (100%) [3]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)
Form
Solid: particulate/powder (100%)
Colour
yellow (100%)
Colour Intensity
light (100%)

Melting/freezing point

Study results
  • 9 studies submitted
  • 5 studies processed
R Melting / freezing point
360 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
360 °C

Boiling point

Study results
  • 7 studies submitted
  • 4 studies processed
R Boiling point
360 °C @ 99.79 - 101.3 kPa [4]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Boiling point at 101 325 Pa
360 °C

Density

Study results
  • 10 studies submitted
  • 6 studies processed
R Relative density
3.5 @ 20 °C [5]
R Tap density
3.4 - 3.6 g/cm³ @ 20 °C [1]

Type of Study provided
Studies with data
Key study 6
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Relative density at 20°C
3.5

Vapour pressure

Study results
  • 6 studies submitted
  • 5 studies processed
R Vapour pressure
0 Pa @ 25 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 9 studies submitted
  • 1 study processed
R Log Pow
0.33 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
Not feasible 4
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 7 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
240 - 1 400 µg/L @ 20 - 25 °C and pH 6.2 [8]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Water solubility
454 - 1 400 µg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 3
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
400 °C

Flammability

Study results
  • 9 studies submitted
  • 4 studies processed
C Interpretation of results
Non flammable (100%) [4]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 7 studies submitted
  • 5 studies processed
C Interpretation of results
Non-explosive (80%), Other: (20%) [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oxidising
No (75%), Non oxidising (25%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 6 studies submitted
  • 1 study processed
R pH
10.3 - 10.6 @ 10 g/L [4]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 4
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in freshwater sediment
1.5 years @ 25 °C

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons. 2
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half-life in soil
48 h @ 23 °C

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
19

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 4
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Koc at 20°C
13.22

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 5 summaries submitted
  • 5 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 100 - 1 040 µg/L (2)
Intermittent releases (freshwater) 2.2 µg/L (1)
Marine water 10 - 104 µg/L (2)
Intermittent releases (marine water) 220 ng/L (1)
Sewage treatment plant (STP) 100 mg/L (3)
Sediment (freshwater) 5.12 - 1 840.77 mg/kg sediment dw (2)
Sediment (marine water) 512 - 184 080 µg/kg sediment dw (2)
Hazard for Air
Air No hazard identified (5)
Hazard for Terrestrial Organism
Soil 413 - 3 819 440 µg/kg soil dw (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (4)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 days) 220 µg/L [5]
LC50 (72 h) 220 µg/L [5]
LC50 (48 h) 220 µg/L [5]
LC50 (24 h) 220 µg/L [5]
LC100 (4 days) 220 µg/L [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
220 - 100 000 µg/L

Long–term toxicity to fish

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
LOEC (72 days) 52 mg/L [1]
LC50 (28 days) 7.31 mg/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
52 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 8 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 270 µg/L [6]
EC50 (24 h) 270 µg/L [6]
EC100 (48 h) 270 µg/L [6]
NOEC (48 h) 270 µg/L [6]

Type of Study provided
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater invertebrates
270 - 100 000 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 1 study processed
P/RResults
LOEC (72 days) 52 mg/L [1]
EC50 (21 days) 97 mg/L [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 2 1
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
52 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 6 studies processed
P/RResults
EC50 (72 h) 710 µg/L [12]
NOEC (72 h) 710 µg/L [9]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 4 summaries processed
EC50 for freshwater algae
710 µg/L
EC10 or NOEC for freshwater algae
710 - 100 000 µg/L
EC10 or NOEC for marine water algae
710 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 5 studies processed
P/RResults
EC50 (3 h) 1 g/L [2]
EC50 (30 min) 1 g/L [2]
IC50 (3 h) 1 g/L [3]
NOEC (3 h) 1 g/L [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
1 g/L
EC10 or NOEC for microorganisms
1 g/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 5 summaries submitted
  • 5 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 46.2 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 100.5 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 50.67 mg/m³ repeated dose toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 6.56 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 8.21 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.36 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.36 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 9 studies submitted
  • 6 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [6]
M/CInterpretations of results
Study cannot be used for classification [1]

Type of Study provided
oral
Studies with data
Key study 6
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
inhalation
  • 6 studies submitted
  • 5 studies processed
P/RResults
LC50 (4 h) 1.9 mg/L air (rat) [5]
M/CInterpretations of results
Toxicity Category IV [1]

inhalation
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 4
other routes
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 19 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: eye
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 2
Other 2
Study data: inhalation
  • 12 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 5 - 500 mg/m³ air [3]
NOAEC (rat): 2.3 mg/m³ air [1]

Study data: inhalation
Studies with data
Key study 5
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 1
Other 2
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Inhalation route - systemic effects:
No adverse effect observed NOAEC 2.3 mg/m³ (subchronic, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 2.3 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 14
Supporting study 4
Weight of evidence 3 1
Other 1
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 5
Weight of evidence 2 1 1
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 5
Other
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons. 3
Other
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant