Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
419-710-0
CAS no.:
42774-15-2
Index number:
Molecular formula:
C26H42N4O2
SMILES:
CC1(C)CC(CC(C)(C)N1)NC(=O)C1=CC(=CC=C1)C(=O)NC1CC(C)(C)NC(C)(C)C1
InChI:
InChI=1S/C26H42N4O2/c1-23(2)13-19(14-24(3,4)29-23)27-21(31)17-10-9-11-18(12-17)22(32)28-20-15-25(5,6)30-26(7,8)16-20/h9-12,19-20,29-30H,13-16H2,1-8H3,(H,27,31)(H,28,32)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
7
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance is harmful if swallowed and causes serious eye irritation.

Breakdown of all 189 C&L notifications submitted to ECHA

Acute Tox. 4 H302 Harmonised Classification
Eye Irrit. 2 H319 Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 10 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 1 000+ tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants and coating products.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).

This substance can be found in products with material based on: rubber (e.g. tyres, shoes, toys) and plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: coating products, adhesives and sealants and polymers.

This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, transfer of substance into small containers, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring and hand mixing with intimate contact only with personal protective equipment available.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

This substance is used in the following products: polymers, coating products and adhesives and sealants.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation in materials and formulation of mixtures.

This substance is used in the following products: polymers, adhesives and sealants and coating products.

This substance is used for the manufacture of: plastic products and machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, batch processing in synthesis or formulation with opportunity for exposure, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: in the production of articles.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not eat, drink or smoke when using this product; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If eye irritation persists: (follow instructions). Rinse cautiously with water for several minutes. Call a poison center or doctor/physician if you feel unwell. If in contact with eyes, remove contact lenses if present and easy to do - continue rinsing. If in eyes: follow instructions specified by manufacturer/supplier. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention. If swallowed: follow instructions specified by manufacturer/supplier. Rinse the mouth. If swallowed: call a poison center or doctor/physician if you feel unwell. Get medical advice/attention.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Clariant Plastics & Coatings (Deutschland) GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Clariant Plastics & Coatings (France), Rue du Flottage B.P. 1 60350 Trosly Breuil France
  • GEELIO Umwelttechnologie GmbH, Augustaanlage 55 D-68165 Mannheim Baden-Würtemberg Germany
  • K CHIMICA, Via Taglio Sinistro 63A 30035 Mirano Veneto Italy
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • [Confidential], [Confidential]

Substance names and other identifiers

1,3-Benzenedicarboxamide, N,N'-bis(2,2,6,6-tetramethyl-4-piperidinyl)-
Other
1,3-Benzenedicarboxamide, N1,N3-bis(2,2,6,6-tetramethyl-4-piperidinyl)-
Other
N,N'-bis(2,2,6,6-tetramethyl-4-piperidinyl) isophthalamide
EU. Com. Reg. No 10/2011 on plastic materials in contact with food
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamide
EC Inventory, C&L Inventory, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC)
<I>N,N'</I>-bis(2,2,6,6-tetrametil-4-piperidil)izoftalamid (hr)
C&L Inventory
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isoftalamid (cs)
C&L Inventory
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isoftalamide (nl)
C&L Inventory
N,N'-bis(2,2,6,6-tetramethyl-4-piperidyl)isophthalamid (da)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametil-4-piperidil)isoftalamida (es)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametil-4-piperidil)isoftalammide (it)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametil-4-piperidil)izoftalamid (sl)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametil-4-piperidil)izopftalamida (ro)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametyl-4-piperidyl)isoftalamid (no)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametylo-4-piperydylo)izoftalamid (pl)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametylpiperidín-4-yl)izoftalamid (sk)
C&L Inventory
N,N'-bis(2,2,6,6-tetrametyyli-4-piperidyyli)isoftalamidi (fi)
C&L Inventory
N,N'-bis(2,2,6,6-tétraméthyl-4-pipéridyl)isophtalamide (fr)
C&L Inventory
N,N'-δις(2,2,6,6-τετραμεθυλo-4-πιπεριδυλ)ισoφθαλαμίδιo (el)
C&L Inventory
N,N’-bis(2,2,6,6-tetrametüül-4-piperidüül)isoftaalamiid (et)
C&L Inventory
N,N’-bis-(2,2,6,6-tetrametil-4-piperidil) izoftalamīds (lv)
C&L Inventory
N,N’-bisz(2,2,6,6-tetrametil-4-piperidil)izoftálamid (hu)
C&L Inventory
N,N′-bis(2,2,6,6-tetrametil-4-piperidil)izoftalamidas (lt)
C&L Inventory
N,N′-бис(2,2,6,6-тетраметил-4-пиперидил)изофталамид (bg)
C&L Inventory
1,3-Benzenedicarboxamide, N,N'-bis(2,2,6,6-tetramethyl-4- piperidinyl)-
C&L Inventory
1-N,3-N-bis(2,2,6,6-tetramethylpiperidin-4-yl)benzene-1,3-dicarboxamide
Registration dossier, Other
N1,N3-bis(2,2,6,6-tetramethylpiperidin-4-yl)benzene-1,3-dicarboxamide
Other
Nylostab
Registration dossier
NYLOSTAB S-EED
Registration dossier
Chiguard N-442
Registration dossier
K.STAB NYST
C&L Inventory
212059-00-2
CAS number
Other
42774-15-2
CAS number
C&L Inventory, Other, EU. Worker Protection-Hazardous (98/24), EU. Dangerous Substances - Eco-Labels, EU. Com. Reg. No 10/2011 on plastic materials in contact with food, EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC)
496934-97-5
CAS number
Other
616-129-00-6
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 4 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Solid: particulate/powder (33%), Powder (33%), Other (33%) [3]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 5 studies processed
R Melting / freezing point
275 - 276 °C @ 10.13 hPa [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
275 °C

Boiling point

Study results
  • 4 studies submitted
  • 1 study processed
R Boiling point
644.06 °C [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 6 studies submitted
  • 5 studies processed
R Relative density
0.58 - 1.119 @ 20.2 - 21 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.119

Vapour pressure

Study results
  • 6 studies submitted
  • 5 studies processed
R Vapour pressure
0 - 1.5 Pa @ 25 - 250 °C [8]

Type of Study provided
Studies with data
Key study 4 1
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 5 studies processed
R Log Pow
1.12 - 1.2 @ 20 °C [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
1.12 @ 20 °C

Water solubility

Study results
  • 6 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
139 mg/L @ 30 °C and pH 10 - 10.1 [5]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
139 mg/L @ 30 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 6 studies submitted
  • 5 studies processed
R Surface tension
69.7 - 70.5 mN/m @ 96 - 125 mg/L and 20 - 30 °C [7]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Surface tension at 20 °C
69.7 mN/m @ 111 mg/L

Flash point

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 8 studies submitted
  • 3 studies processed
C Interpretation of results
Non flammable (100%) [3]

Type of Study provided
Studies with data
Key study 7
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 6 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 7 studies submitted
  • 3 studies processed
C Interpretation of results
Not readily biodegradable (67%), Under test conditions no biodegradation observed (33%) [3]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
97

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 64 µg/L (1)
Intermittent releases (freshwater) -
Marine water 6.4 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 14.8 mg/L (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil No hazard identified (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 5 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 110 - 250 mg/L [4]
LC50 (72 h) 250 mg/L [3]
LC50 (48 h) 110 - 250 mg/L [4]
LC50 (24 h) 250 mg/L [3]
LC100 (4 days) 250 mg/L [3]

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 15 - 250 mg/L [7]
EC50 (24 h) 250 mg/L [5]
EC100 (48 h) 250 mg/L [5]
NOEC (48 h) 1 - 100 mg/L [4]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
15 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 10 mg/L [1]
LOEC (21 days) 32 mg/L [1]
EC50 (21 days) 24.7 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
10 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 7 studies submitted
  • 6 studies processed
P/RResults
EC50 (72 h) 250 mg/L [10]
NOEC (72 h) 1 - 250 mg/L [12]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
52 mg/L
EC10 or NOEC for freshwater algae
3.2 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
EC50 (3 h) 1.25 g/L [1]
IC50 (3 h) 1.25 g/L [1]
NOEC (3 h) 100 - 148 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1.25 g/L
EC10 or NOEC for microorganisms
148 mg/L

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (14 days) 1 g/kg soil dw [1]
LC0 (14 days) 1 g/kg soil dw [1]
LC100 (14 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
1 g/kg soil dw

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (24 days) 100 mg/kg soil dw [2]
NOEC (23 days) 100 mg/kg soil dw [1]
LOEC (24 days) 100 mg/kg soil dw [2]
LOEC (23 days) 100 mg/kg soil dw [1]
EC50 (24 days) 100 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Long-term EC10 / LC10 / NOEC
100 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 79.3 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (No hazard identified) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 11.3 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (No hazard identified) -
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 19.6 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 109 mg/m³ acute toxicity
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (No hazard identified) -
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.6 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 31.3 mg/kg bw/day acute toxicity
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (No hazard identified) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 5.6 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 31.3 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 7 studies submitted
  • 5 studies processed
P/RResults
LD50 1 253 - 1 258 mg/kg bw (rat) [3]
M/CInterpretations of results
Harmful [3]

Type of Study provided
oral
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 4 studies submitted
  • 3 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [3]

dermal
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 1 253 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 1 study processed
P/RResults
NOEL (rat): 450 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 3
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 450 mg/kg bw/day (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 9
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 540 mg/kg bw/day (subacute, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant