Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name:
  • IUPAC name: 2-ethylheptyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate bis(2-ethylhexyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) 2-ethylpentyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 3-methylhexyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 4-methyloctyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 6-methylheptyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
  • Substance names and other identifiers
EC / List no.:
406-040-9
CAS no.:
125643-61-0
Index number:
Molecular formula:
C175H294O21
SMILES:
CCCC(C)CCOC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CCCC(CC)COC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CCCCC(CC)COC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CCCCC(CC)COC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CC(C)CCCCCOC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CCCCCC(CC)COC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C.CCCCC(C)CCCOC(=O)CCC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
InChI:
InChI=1/2C26H44O3.3C25H42O3.2C24H40O3/c1-9-10-12-19(2)13-11-16-29-23(27)15-14-20-17-21(25(3,4)5)24(28)22(18-20)26(6,7)8;1-9-11-12-13-19(10-2)18-29-23(27)15-14-20-16-21(25(3,4)5)24(28)22(17-20)26(6,7)8;1-18(2)12-10-9-11-15-28-22(26)14-13-19-16-20(24(3,4)5)23(27)21(17-19)25(6,7)8;2*1-9-11-12-18(10-2)17-28-22(26)14-13-19-15-20(24(3,4)5)23(27)21(16-19)25(6,7)8;1-9-10-17(2)13-14-27-21(25)12-11-18-15-19(23(3,4)5)22(26)20(16-18)24(6,7)8;1-9-11-17(10-2)16-27-21(25)13-12-18-14-19(23(3,4)5)22(26)20(15-18)24(6,7)8/h17-19,28H,9-16H2,1-8H3;16-17,19,28H,9-15,18H2,1-8H3;16-18,27H,9-15H2,1-8H3;2*15-16,18,27H,9-14,17H2,1-8H3;15-17,26H,9-14H2,1-8H3;14-15,17,26H,9-13,16H2,1-8H3
Type of substance:
UVCB
Origin:
Organic
Registered compositions:
20
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
ELINCS (European LIst of Notified Chemical Substances) List

Hazard classification & labelling

According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may cause long lasting harmful effects to aquatic life.

Breakdown of all 754 C&L notifications submitted to ECHA

Aquatic Chronic 4 H413 Harmonised Classification
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 20 active registrations under REACH, 2 Joint Submission(s) and 5 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: lubricants and greases and coating products.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal) and formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones).

This substance is used in the following products: lubricants and greases, heat transfer fluids, hydraulic fluids and metal working fluids.

This substance is used for the manufacture of: machinery and vehicles.

This substance is used in the following activities or processes at workplace: transfer of chemicals and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: metal working fluids, polymers, lubricants and greases and hydraulic fluids.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: polymers, lubricants and greases and metal working fluids.

This substance is used for the manufacture of: plastic products.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation, transfer of chemicals, treatment of articles by dipping and pouring, transfer of substance into small containers, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Release to the environment of this substance can occur from industrial use: in the production of articles, in processing aids at industrial sites and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal).

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and in processing aids at industrial sites.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: avoid release to the environment.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • CCD (Germany) GmbH, Graf-Adolf-Strasse 68 40210 Düsseldorf Germany
  • Chemservice S.A. (8LF5), 13, Fausermillen 6689 Mertert Luxembourg
  • Everspring Europe Sprl, Rue Rodenbach 125 1190 Brussels Belgium
  • LANXESS Sales Netherlands B.V., Kraanspoor 50 1033 SE Amsterdam Netherlands
  • Oxiris Chemicals S.A., Ctra C-35 Km59 Pol Ind Nord-est 08470 Sant Celoni Spain
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP( Shanghai Petrochem. xinier Chemical & industry Co.,Ltd.), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP(acts as OR for Beijing Xinzerui Science&Technology Development Co.,Ltd. Auxiliary Branch), Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACHLaw Ltd( acting as OR for Yasho Industries Limited), Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • Rianlon GmbH, Charlottenstr. 75 40210 Duesseldorf Germany
  • SI Group Germany (DEAB) GmbH, Teplitzer Strasse 14-16 84478 Waldkraiburg Germany
  • [Confidential], [Confidential]
  • BASF Lampertheim GmbH, Chemiestrasse 22 68619 Lampertheim Germany

Substance names and other identifiers

2-ethylpentyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Other
ALBETEC-4716
REACH pre-registration
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, C7-9-branched alkyl esters
Other
Reaction mass of Isomers of: C7-9-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
C&L Inventory, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Waste Framework Directive, Annex III - Waste - Hazardous Properties
amestec de izomeri de: C7-9-alchil 3-(3,5-di-trans-butil-4-hidroxifenil)propionat (ro)
C&L Inventory
Blanding af isomerer af: C7-9-alkyl-3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionat (da)
C&L Inventory
blanding av isomere av: C7-9-alkyl-3-(3,5-di-tert-butyl-4-hydroksyfenyl)propionat (no)
C&L Inventory
C7-9-alkil 3-(3,5-di-transz-butil-4-hidroxifenil)propionate izomerek keveréke (hu)
C&L Inventory
C7-9-alküül-3-(3,5-di-trans-butüül-4-hüdroksüfenüül)propionaadi isomeeride segu (et)
C&L Inventory
Een mengsel van isomeren van: C7-9-alkyl-3-(3,5-di-trans-butyl-4-hydroxyfenyl)propionaat (nl)
C&L Inventory
En blandning av isomerer av C7-9-alkyl-3-(3,5-di-tert-butyl-4-hydroxifenyl)propionat (sv)
C&L Inventory
hidroksifenil)propionat (hr)
C&L Inventory
Isomeerien seos: C7-9-alkyyli-3-(3,5-di-tert-butyyli-4-hydroksifenyyli)propionaatti (fi)
C&L Inventory
Izomēru maisījums: C7-9-alkil 3-(3,5-di-trans-butil-4-hidroksifenil)propionāts (lv)
C&L Inventory
masse de réaction d'isomères de: 3-(3,5-tert-butyl-4-hydroxyphényl)propionate de C7-9-alkyle (fr)
C&L Inventory
mezcla de isómeros de: 3-(3,5-di-trans-butil-4-hidroxifenil)propionato de C7-9-alquilo (es)
C&L Inventory
Mieszanina poreakcyjna izomerów: 3-(3,5-di-trans-butylo-4-hydroksyfenylo)propionian C7.9-alkilowy (pl)
C&L Inventory
miscela di isomeri di: 3-(3,5-di-terz-butil-4-idrossifenil)propionato di C7-9-alchile (it)
C&L Inventory
mistura de isómeros de 3-(3,5-di-terc-butil-4-hidroxifenil)propionato de alquilo C7-9 (pt)
C&L Inventory
mišinys: C7-9-alkil-3-(3,5-di-trans-butil-4-hidroksifenil)propanoato izomerų (lt)
C&L Inventory
Mίγμα ισoμερών του 3-(3,5-δι-τριτ.βoυτυλ-4-υδρoξυφαινυλo)πρoπιoνικoύ C7-9-αλκυλεστέρα (el)
C&L Inventory
Reaction mass von Isomeren aus C7-9-Alkyl-3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionat (de)
C&L Inventory
reakcijska smjesa izomera: C7-9-alkil 3-(3,5-di-terc-butil-4- (hr)
C&L Inventory
reakčná zmes izomérov O-(C7-9-alkyl)-3-(3,5-di-terc-butyl-4-hydroxyfenyl)propanoátu (sk)
C&L Inventory
reakční směs isomerů: C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyfenyl)propionátů (cs)
C&L Inventory
Taħlita ta’ iżomeri ta’: C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate (mt)
C&L Inventory
zmes izomerov: C7-9-alkil 3-(3,5-di-trans-butil-4-hidroksifenil)propionat (sl)
C&L Inventory
реакционна маса от изомери на: C7-9-алкил 3-(3,5-ди-терт-бутил-4-хидроксифенил)пропионат (bg)
C&L Inventory
2-ethylheptyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate bis(2-ethylhexyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate) 2-ethylpentyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 3-methylhexyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 4-methyloctyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate 6-methylheptyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Registration dossier, Other
2-ethylpentyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
C&L Inventory
3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic Acid (C7-C9) Branched Alkyl Esters
C&L Inventory
[Hostanox O 135]Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-, C7-9-branched alkyl esters
C&L Inventory
ALBETEC-4716; AN-1216; IRGANOX 1135; IRGANOX L 135
C&L Inventory
Benzenepropanoic acid, 3,5-bis(1,1-dimethylethyl)-4-hydroxy-,C7-9-branched alkyl esters
C&L Inventory
Benzenepropanoic acid,3,5-bis(1,1-dimethylethyl)-4-hydroxy-, C7-9-branched alkyl esters
C&L Inventory
C7-9-(branched)-alkyl 3-(3,5-di-tert- butyl-4-hydroxyphenyl)propanoate
C&L Inventory
C7-9-(branched)-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate
Registration dossier
C7-9-(branched)-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Registration dossier
Chinox 35
Registration dossier
Evernox 1135 (100-1000T Fullspring)
Registration dossier
octyl 3-(3,5-ditert-butyl-4-hydroxyphenyl)propanoate
Other
Reaction mass of 125643-61-0 and 6386-38-5
C&L Inventory
Reaction mass of C7-9-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Registration dossier
Reaction mass of C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate
Registration dossier
reaction mass of isomers of C7-9-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Registration dossier
Reaction mass of isomers of C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate
C&L Inventory, Registration dossier
Reaction mass of isomers of C7-9-alkyl-3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate
Registration dossier
Reaction mass of isomers of: C7- 9-alkyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
Registration dossier
Reaction mass of isomers of: C7-9-alkyl 3-(3,5-di-trans-butyl-4-hydroxyphenyl)propionate
C&L Inventory, Registration dossier
UV1135
Registration dossier
Z-72
Registration dossier
A.O. 1135
Registration dossier
Benzenepropanoic acid,3,5-bis(1,1-dimethyl-ethyl)-4,4hydroxy-C7-C9 alkyl esters
Registration dossier
Benzenepropanoicacid,3,5-bis(1,1-dimethyl-ethyl)-4hydroxy-C7-C9-branchedalkylesters
Registration dossier
Ethanox 4716
Registration dossier
Evernox 1135
Registration dossier
IRGANOX 1135
Registration dossier
IRGANOX L 135
Registration dossier
Nauguard 531
Registration dossier
Nauguard PS-48
Registration dossier
Songnox 1135 LQ
Registration dossier
THANOX 1135
Registration dossier
Vanlube BHC
Registration dossier
YALUB PA 135
Registration dossier
125643-61-0
CAS number
C&L Inventory, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Waste Framework Directive, Annex III - Waste - Hazardous Properties
607-530-00-7
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 11 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [4]
C Form
Not specified (67%), Refrigerated liquid (33%) [3]
C Odour
Other (67%), Slight (33%) [3]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 1 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 7 studies processed
R Melting / freezing point
-44.2 - -12.15 °C [7]

Type of Study provided
Studies with data
Key study 7
Supporting study 1 1 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Melting / freezing point at 101 325 Pa
-44.2 - -23 °C

Boiling point

Study results
  • 10 studies submitted
  • 7 studies processed
R Boiling point
127 - 370.65 °C @ 11 - 102 340 Pa [8]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 1 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Boiling point at 101 325 Pa
343 - 370.65 °C

Density

Study results
  • 10 studies submitted
  • 7 studies processed
R Density
0.959 - 0.967 g/cm³ @ 20 °C [2]
R Relative density
0.964 - 0.97 @ 20 °C [5]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 2 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Relative density at 20°C
0.96 - 0.97

Vapour pressure

Study results
  • 9 studies submitted
  • 6 studies processed
R Vapour pressure
0 - 11 Pa @ 25 - 127 °C [10]

Type of Study provided
Studies with data
Key study 5 1
Supporting study 1 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Vapour pressure
0 - 0.002 Pa @ 20 - 25 °C

Partition coefficient

Study results
  • 12 studies submitted
  • 7 studies processed
R Pow
15 100 000 @ 30 °C and pH 6.9 [1]
R Log Pow
6.2 - 9.2 @ 0 - 30 °C and pH 0 - 6.9 [7]

Type of Study provided
Studies with data
Key study 5 1 1
Supporting study 1 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Log Kow (Log Pow)
7.18 - 9.2 @ 0 - 30 °C

Water solubility

Study results
  • 13 studies submitted
  • 7 studies processed
R Water solubility (mass/vol.)
500 - 121 000 ng/L @ 20 °C and pH 6 - 8.45 [7]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 1 1 2
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Water solubility
30 - 121 µg/L @ 20 °C

Solubility in organic solvents / fat solubility

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 7 studies submitted
  • 3 studies processed
R Surface tension
66.9 - 68.7 mN/m @ 9.87 g/L and 20 °C [3]

Type of Study provided
Studies with data
Key study 6
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Surface tension at 20 °C
59.7 - 67.8 mN/m @ 9 870 - 10 080 mg/L

Flash point

Study results
  • 9 studies submitted
  • 6 studies processed
R Flash point
126 - 152 °C @ 101.3 - 101.325 kPa [6]

Type of Study provided
Studies with data
Key study 6
Supporting study 1 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Flash point at 101 325 Pa
126 - 152 °C

Auto flammability

Study results
  • 8 studies submitted
  • 6 studies processed
R Autoflammability / self-ignition
351 - 365 °C @ 97.85 - 101.325 kPa [6]

Type of Study provided
Studies with data
Key study 5 1
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Autoflammability / self-ignition at 101 325 Pa
356 - 365 °C

Flammability

Study results
  • 11 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 7
Exposure cons.
Other 1
C Summaries
  • 4 summaries submitted
  • 3 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 6 studies submitted
  • 5 studies processed
C Interpretation of results
Non-explosive (100%) [5]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 3
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
12.4 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 5 studies submitted
  • 4 studies processed
R dynamic viscosity (in mPa s)
110 - 650 [6]
R kinematic viscosity (in mm²/s)
6.2 [1]

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
Static viscosity at 20 °C
6.2 mm²/s
Dynamic viscosity at 20 °C
119.29 - 635 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other 1 1
Data waiving
Not feasible 2
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 23 studies submitted
  • 9 studies processed
R COD
2.42 g O2/g test material [1]
C Interpretation of results
Under test conditions no biodegradation observed (67%), Not inherently biodegradable (22%), Readily biodegradable but failing the 10-day window (11%) [9]

Type of Study provided
Studies with data
Key study 7
Supporting study 3 1
Weight of evidence 1 6
Other 3 2
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons. 1
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 1 1
Supporting study
Weight of evidence 1
Other 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
49 L/kg ww
Bioaccumulation Factor (BCF) - dimensionless
260

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3 1 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Koc at 20°C
12 200 - 33 884

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
0.266 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 5 summaries submitted
  • 5 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 4.3 - 30 µg/L (4)
Intermittent releases (freshwater) 18 - 43 µg/L (4)
Marine water 30 - 1 800 ng/L (4)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) 1 - 100 mg/L (5)
Sediment (freshwater) 370 - 233 000 µg/kg sediment dw (5)
Sediment (marine water) 37 - 23 300 µg/kg sediment dw (5)
Hazard for Air
Air No hazard identified (2)
Hazard for Terrestrial Organism
Soil 50 - 189 000 µg/kg soil dw (5)
Hazard for Predators
Secondary poisoning 33 - 41 330 µg/kg food (4)

Short–term toxicity to fish

Study results
  • 12 studies submitted
  • 7 studies processed
P/RResults
LC50 (14 days) 100 mg/L [1]
LC50 (4 days) 1.1 - 1 000 000 µg/L [7]
NOEC (4 days) 1.1 - 14 000 µg/L [3]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 2 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
74 - 1 000 mg/L

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
NOEC (36 days) 1 µg/L [2]
NOEC (33 days) 360 µg/L [1]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
1 µg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 14 studies submitted
  • 9 studies processed
P/RResults
EC50 (48 h) 8.2 - 1 000 000 µg/L [7]
EC50 (24 h) 4.3 mg/L [2]
NOEC (48 h) 8.2 - 360 µg/L [4]
EL50 (48 h) 100 - 110 mg/L [2]
NOELR (48 h) 56 mg/L [1]

Type of Study provided
Studies with data
Key study 7 2
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 / LC50 for freshwater invertebrates
224 - 1 000 000 µg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
NOEC (21 days) 10 µg/L [2]
NOELR (21 days) 3.2 mg/L [1]
LOELR (21 days) 10 mg/L [1]
EL50 (21 days) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 3 3
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
10 µg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 12 studies submitted
  • 8 studies processed
P/RResults
EC50 (72 h) 180 - 3 000 000 ng/L [14]
NOEC (72 h) 140 - 3 000 000 ng/L [14]
LOEC (72 h) 180 ng/L [3]
EL50 (72 h) 100 mg/L [1]
NOELR (72 h) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 7 2
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
3 mg/L
EC10 or NOEC for freshwater algae
3 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to microorganisms

Study results
  • 13 studies submitted
  • 8 studies processed
P/RResults
EC50 (3 h) 100 - 1 000 mg/L [5]
EC50 (30 min) 1 g/L [1]
IC50 (3 h) 100 mg/L [3]
NOEC (3 h) 100 - 1 000 mg/L [7]
NOEC (30 min) 1 g/L [1]

Type of Study provided
Studies with data
Key study 6 2
Supporting study 4
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
100 - 1 000 mg/L
EC10 or NOEC for microorganisms
100 - 1 000 mg/L

Sediment toxicity

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 37 - 1 000 mg/kg sediment dw [4]
LOEC (28 days) 320 mg/kg sediment dw [1]
EC50 (28 days) 1 000 mg/kg sediment dw [2]
LC50 (28 days) 1 000 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOEC (56 days) 250 mg/kg soil dw [1]
NOEC (28 days) 1 g/kg soil dw [1]
NOEC (14 days) 1 g/kg soil ww [1]
LOEC (56 days) 500 mg/kg soil dw [1]
LOEC (28 days) 1 g/kg soil dw [1]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 1 summary processed
Short-term EC50 / LC50
1 g/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 180 - 1 000 mg/kg soil dw [6]
EC50 (21 days) 290 - 1 000 mg/kg soil dw [6]
EC50 (19 days) 100 mg/kg soil dw [3]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (28 days) 31.6 - 1 000 mg/kg soil dw [2]
NOEC (28 days) 1 g/kg soil ww [1]
EC50 (28 days) 497 mg/kg soil dw [1]
EC50 (28 days) 1 g/kg soil ww [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 5 summaries submitted
  • 5 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.33 mg/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 1 750 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 220 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 20 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 6 µg/cm² repeated dose toxicity
Acute /short term: (DNEL) 1 mg/cm² acute toxicity
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 740 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 875 mg/m³ acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 330 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 50 mg/kg bw/day acute toxicity
Local Effects
Long-term: No hazard identified
Acute /short term: (DNEL) 8.33 mg/cm² skin irritation/corrosion
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 160 µg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 50 mg/kg bw/day acute toxicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1 3
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 50 %
Dermal: 10 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 9 studies processed
P/RResults
LD50 500 - 2 000 mg/kg bw (rat) [9]
M/CInterpretations of results
Practically nontoxic [1]

Type of Study provided
oral
Studies with data
Key study 5
Supporting study 2
Weight of evidence 4
Other 1
Data waiving
no waivers
inhalation
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons. 3
Other 1
dermal
  • 9 studies submitted
  • 6 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [6]
M/CInterpretations of results
Not classified [6]

dermal
Studies with data
Key study 4
Supporting study 2
Weight of evidence 2
Other 1
Data waiving
no waivers
other routes
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study 1
Weight of evidence 1 3
Other 1
Data waiving
no waivers
Study data: eye
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 5
Supporting study 3
Weight of evidence 1 3
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5
Supporting study 1
Weight of evidence 1 4
Other
Data waiving
no waivers
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 19 studies submitted
  • 10 studies processed
P/RResults
NOAEL (rat): 3 - 750 mg/kg bw/day [6]
NOAEL (rat): 2 500 ppm [3]
NOEL (rat): 3 - 15 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 6
Supporting study 6
Weight of evidence 4
Other 2
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: inhalation
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons. 1
Other
Study data: dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 500 - 1 000 mg/kg bw/day [2]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 5 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 500 mg/kg bw/day (subacute, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 7
Supporting study
Weight of evidence 7
Other 1
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other 1
Study data: in vivo
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 5
Supporting study 2
Weight of evidence 1 2
Other 2
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 218 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Study data: developmental
  • 11 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 4 1
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 205 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 205 mg/kg bw/day (subchronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant