Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
295-405-4
CAS no.:
92045-23-3
Index number:
649-116-00-9
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
32
Of which contain:
1 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause genetic defects, may cause cancer and is an extremely flammable gas.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is harmful to aquatic life with long lasting effects and contains gas under pressure and may explode if heated.

Breakdown of all 193 C&L notifications submitted to ECHA

Flam. Gas 1 H220 Harmonised Classification
Muta. 1B H340 Harmonised Classification
Press. Gas (Liq.) H280
Carc. 1A H350 Harmonised Classification
Carc. 1B H350
Aquatic Chronic 3 H412
Flam. Liq. 2 H225
Acute Tox. 4 H302
STOT SE 3 H336
Press. Gas Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (95.65% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is broad agreement in that a majority of data submitters agree this substance is Mutagenic (95.65% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 24 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: fuels.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: fuels. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, laboratory work, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance and in processing aids at industrial sites.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; do not allow contact with air; take actions to prevent static discharges; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; obtain special instructions before use; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: In case of leakage eliminate all ignition sources. In case of leaking gas fire do not extinguish unless leak can be stopped safely. If exposed or concerned: get medical advice/attention.

Storage statements

Store this substance protected from sunlight and in a well-ventilated place; locked up.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Basell Polyolefine Gmbh, Bruhler strasse 60 D-50389 Wesseling Germany
  • Basell Polyoléfines France SAS, Chemin Departemental 21 A 13130 Berre l'Etang France
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Borealis AG, Wagramerstrasse 17-19 1220 Wien Austria
  • Borealis Polymers Oy, P.O. Box 330 06101 Porvoo Finland
  • Butadien Kralupy a.s., O.Wichterleho 810 27801 Kralupy nad Vltavou Czech Republic
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • DOW CHEMICAL IBERICA S.L., Ribera del Loira 4-6 Edificio Iris, 4º Planta 28042 Madrid Spain
  • DOW OLEFINVERBUND GMBH, Strasse B 13 D-06258 Schkopau Germany
  • Evonik Operations GmbH, Rellinghauser Straße 1-11 45128 Essen Germany
  • Evonik Oxeno Antwerpen N.V., Tijsmanstunnel West 2040 Antwerpen Belgium
  • ExxonMobil Chemical France SARL, 20 Rue Paul Heroult 92000 Nanterre France
  • MOL Petrochemicals Private Company Limited by Shares, TVK-Ipartelep, TVK Központi Irodaház (136. sz. épület, hrsz: 2119/3) 3581 Tiszaujvaros Hungary
  • Naphtachimie SA, Place de la Coupole, 2 La Défence 6 92400 Courbevoie France
  • Neste Oyj, Keilaranta 21 FI-02150 Espoo Finland
  • Petroleos del Norte, S.A., Ed. Muñatones, Bº San Martín, 5 48550 Muskiz Vizcaya Spain
  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland
  • Repsol Petroleo, S.A., Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • REPSOL POLIMEROS, UNIPESSOAL LDA, Monte Feio 7520-954 Sines Portugal
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • Shell Deutschland GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany
  • Total Petrochemicals & Refining SA, Rue de l'Industrie,52 1040 Bruxelles Belgium
  • Total Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France
  • Borealis AB, Stenungsund 44486 Stenungsund Sweden
  • ExxonMobil Chemical Ltd., Ermyn Way ExxonMobil House KT22 8UX Surrey Leatherhead United Kingdom
  • OLTCHIM SA, Uzinei 1 240050 Ramnicu Valcea Valcea Romania
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • SABIC UK Petrochemicals Limited, Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France

Substance names and other identifiers

[A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12 °C to 5 °C (10.4 °F to 41 °F).]
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
C&L Inventory
Hydrocarbons, C4, steam-cracker distillate
EC Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Hydrocarbons, C4, steam-cracker distillate
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Hydrocarbons, C4, steam-cracker distillate; Petroleum gas [A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12 o C to 5 o C (10.4 °F to 41°F).]
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Hydrocarbons, C4, steam-cracker distillate; Petroleum gas
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
Petroleum gas
A complex combination of hydrocarbons produced by the distillation of the products of a steam cracking process. It consists predominantly of hydrocarbons having a carbon number of C4, predominantly 1-butene and 2-butene, containing also butane and isobutene and boiling in the range of approximately minus 12°C to 5°C (10.4°F to 41°F).
C&L Inventory
(Keerulise koostisega süsivesinike segu, mis tekib auru krakkimise produktide destilleerimisel. Koosneb peamiselt süsivesinikest süsiniku aatomite arvuga C4, valdavalt 1-buteen ja 2-buteen, sisaldades ka butaani ja isobuteeni, keemispiiridega umbes –12°C kuni 5 °C.) (et)
C&L Inventory
[Kompleks blanding av hydrokarboner fremstilt ved destillasjon av produktene fra en dampkrakkingsprosess. Består for det meste av C4-hydrokarboner, hovedsakelig 1-buten og 2-buten, men inneholder også butan og isobuten og har omtrentlig kokepunktsintervall fra -12 °C til 5 °C (10,4 °F til 41 °F).] (no)
C&L Inventory
[Kompleksna kombinacija ogljikovodikov dobljena z destilacijo produktov parnega krekinga. Sestoji pretežno iz ogljikovodikov s številom ogljikovih atomov C4, pretežno 1-buten, 2-buten, vsebujoč tudi butan in izobuten ter z vreliščem v območju približno med –12 °C in 5 °C.] (sl)
C&L Inventory
[komplexe Kombination von Kohlenwasserstoffen, hergestellt durch Destillation der Produkte aus einem Dampfkrackverfahren; besteht vorwiegend aus Kohlenwasserstoffen mit einer Kohlenstoffzahl von C4, überwiegend 1-Buten und 2-Buten; enthält auch Butan und Isobuten mit einem Siedebereich von etwa 12 °C bis 5 °C] (de)
C&L Inventory
[Komplexná zmes uhľovodíkov získavaná destiláciou produktov z procesu parného krakovania. Pozostáva predovšetkým z uhľovodíkov s počtom atómov uhlíka C4, predovšetkým z but-1-énu a but-2-énu a čiastočne butánu a izobuténu. Má teplotu varu v rozmedzí približne od mínus 12 °C do 5 °C.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi produsă printr-un proces de cracare cu vapori. Constă cu precădere în hidrocarburi având numărul de atomi de carbon C4, predominând 1-butena şi 2-butena, conţinând de asemenea butan şi izobutan şi având punctul de fierbere cuprins între aproximativ minus 12°C şi 5°C (10.4°F şi 41°F).] (ro)
C&L Inventory
[Ogļūdeņražu savienojumu komplekss, kas iegūts, destilējot tvaika krekinga procesa produktus. Sastāv galvenokārt no ogļūdeņražiem ar oglekļa atomu skaitu C4, pārsvarā no 1-butēna un 2-butēna, satur arī butānu un izobutānu, aptuvenā viršanas temperatūra -12°C līdz 5°C (10,4°F līdz 41°F).] (lv)
C&L Inventory
[Složeni sastav ugljikovodika proizvedenih destilacijom produkata iz procesa parnog krekinga. Sastoji se pretežito od ugljikovodika koji imaju broj ugljikovih atoma C4, pretežito 1-buten i 2-buten, koji sadrže također butan i izobuten a vriju u području približno –12 °C do 5 °C. ] (hr)
C&L Inventory
[Složitá směs uhlovodíků získaná destilací produktů pyrolýzy. Je složena převážně z uhlovodíků C4, převážně 1-butenu a 2-butenu, a obsahuje rovněž butan a isobuten a má rozmezí bodu varu -12 °C až 5 °C.] (cs)
C&L Inventory
[Sudėtinis angliavandenilių mišinys, gaunamas distiliuojant krekingo vandens garais proceso produktus. Jį iš esmės sudaro angliavandeniliai, turintys anglies atomų skaičių C4, daugiausia 1-butenas ir 2-butenas, be to, turi butano ir izobuteno, virimo temperatūra maždaug nuo − 12 °C iki 5 °C (nuo –10,4 °F iki 41 °F).] (lt)
C&L Inventory
[Szénhidrogének komplex elegye, melyet a gőzkrakkolási folyamat termékeinek desztillációjával állítanak elő. Főleg olyan szénhidrogénekből áll, melyek szénatomszáma C4, elsősorban 1-buténből és 2-buténből, de tartalmaz még butánt és izobutént is. Közelítőleg a mínusz 12°C-tól 5°C-ig (10,4°F-től 41°F-ig) terjedő tartományban forr.] (hu)
C&L Inventory
[Złożona mieszanina węglowodorów wytworzona przez destylację produktów procesu krakingu parowego. Składa się głównie z węglowodorów o liczbie atomów węgla C4, głównie 1-butanu i 2-butanu, zawierających także butan i izobuten i wrze w zakresie ok. od minus 12°C do 5°C (10,4°F do 41°F).] (pl)
C&L Inventory
[Πολύπλοκος συνδυασμός υδρογονανθράκων που παράγεται με απόσταξη προϊόντων ατμοπυρόλυσης. Συνίσταται κυρίως από υδρογονάνθρακες με αριθμό ατόμων άνθρακα C4, κυρίως 1-βουτένιο και 2-βουτένιο. Περιέχει επίσης βουτάνιο και ισοβουτένιο και αποστάζει μεταξύ -12°C και 5°C περίπου.] (el)
C&L Inventory
[Комплексна комбинация от въглеводороди, получена при дестилация на продукти от паров крекинг процес. Състои се основно от въглеводороди с брой на въглеродните атоми С4, преобладаващо 1-бутен и 2-бутен, съдържа също бутан и изобутен и с температура на кипене приблизително в интервала от минус 12 °C до 5 °C (10.4°F до 41°F).] (bg)
C&L Inventory
Angliavandeniliai, C4, krekingo vandens garais distiliatai (lt)
C&L Inventory
C4-uhľovodíky, z destilácie z parného krakovania (sk)
C&L Inventory
carbonhydrider, C4-, dampkrakker-destillat (da)
C&L Inventory
combinación compleja de hidrocarburos producida por la destilación de los productos de un proceso de craqueo a vapor; compuesta principalmente de hidrocarburos con un número de carbonos de C4, en su mayor parte 1-buteno y 2-buteno, también con butano e isobuteno y con un intervalo de ebullición aproximado de -12 °C a 5 °C (es)
C&L Inventory
Combinaison complexe d'hydrocarbures obtenue par distillation des produits résultant d'un vapocraquage. Se compose principalement d'hydrocarbures en C4, essentiellement du butène-1 et du butène-2, et contient aussi du butane et de l'isobutène; son point d'ébullition est compris entre -12 °C et 5 °C. (fr)
C&L Inventory
Combinazione complessa di idrocarburi prodotta dalla distillazione dei prodotti di un processo di steam cracking. È costituita in prevalenza da idrocarburi con numero di atomi di carbonio C4, prevalentemente 1-butene e 2-butene, contiene inoltre butano ed isobutene; punto di ebollizione nell'intervallo da -12°C a 5°C ca. (da 10,4°F a 41°F). (it)
C&L Inventory
Combinação complexa de hidrocarbonetos obtida por destilação dos produtos de um processo de steam cracking. É constituída predominantemente por hidrocarbonetos com número de átomos de carbono C4, com predominância de 1-buteno e 2buteno e contendo também butano e isobuteno; destila no intervalo aproximado de -12 °C a 5 °C. (pt)
C&L Inventory
Een complexe verzameling koolwaterstoffen die wordt verkregen door de destillatie van de producten uit een stoomkraakproces. Bestaat voornamelijk uit C4-koolwaterstoffen, overwegend 1-buteen en 2-buteen; bevat ook butaan en isobuteen en heeft een kooktraject van ongeveer -12°C tot 5°C. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider fremstillet ved destillationen af produkterne fra en dampkrakningsproces. Den består overvejende af C4-carbonhydrider, overvejende 1-buten og 2-buten, og indeholder også butan og isobuten, med kogeinterval omtrent fra minus 12°C til 5°C (10,4 ºF til 41 ºF). (da)
C&L Inventory
gas di petrolio (it)
C&L Inventory
Gase aus der Erdölverarbeitung (de)
C&L Inventory
gases de petróleo (es)
C&L Inventory
gaz de pétrole (fr)
C&L Inventory
Gaz petrolier (mt)
C&L Inventory
Gaz petrolier (ro)
C&L Inventory
Gaz z ropy naftowej (pl)
C&L Inventory
Gás de petróleo (pt)
C&L Inventory
Hidrocarbonetos, C4, destilado de steam cracking (pt)
C&L Inventory
Hidrocarburi, C4, distilat de cracare cu vapori (mt)
C&L Inventory
Hidrocarburi, C4, distilat de cracare cu vapori (ro)
C&L Inventory
hidrocarburos, C4, destilado del craqueador a vapor (es)
C&L Inventory
Hiilivedyt, C4, höyrykrakkausyksikkötisle (fi)
C&L Inventory
Hydrocarbures riches en C4, distillat de vapocraquage;gaz de pétrole;[combinaison complexe d'hydrocarbures obtenue par distillation des produits résultant d'un vapocraquage. Se compose principalement d'hydrocarbures en C4, essentiellement du 1-butène et du 2-butène, et contient aussi du butane et de l'isobutène; son intervalle d'ébullition est compris entre - 12 et 5 oC (entre 10,4 et 41 oF).] (fr)
C&L Inventory
hydrokarboner, C4-, dampkrakkerdestillat (no)
C&L Inventory
idrocarburi, C4, distillato da steam cracking (it)
C&L Inventory
Kohlenwasserstoffe, C4, Destillat nach Dampfkracken (de)
C&L Inventory
Kolväten, C4-, ångkrackerdestillat (sv)
C&L Inventory
Komplex blandning av kolväten erhållen genom destillation av produkter från ångkrackning. Består främst av C4-kolväten, i synnerhet 1-buten och 2-buten, men innehåller även butan och isobutan, med ungefärligt kokpunktsintervall från -12 °C till +5 °C. (sv)
C&L Inventory
Koolwaterstoffen, C4-, stoomkrakerdestillaat (nl)
C&L Inventory
Kulbrintegasser (da)
C&L Inventory
Kőolaj gáz (hu)
C&L Inventory
Maaöljykaasu (fi)
C&L Inventory
Monimutkainen seos hiilivetyjä, saatu tislaamalla höyrykrakkausprosessin tuotteita. Koostuu pääasiassa hiilivedyistä, joiden hiililuvut ovat C4, pääasiassa 1-buteenista ja 2-buteenista, sisältää myös butaania ja isobuteenia ja kiehuu likimäärin välillä -12°C:sta 5°C:een (10,4°F:sta 41°F:iin). (fi)
C&L Inventory
Naftagaas (et)
C&L Inventory
Naftas gāze (lv)
C&L Inventory
Naftni plin (hr)
C&L Inventory
Naftos dujos (lt)
C&L Inventory
O combinaţie complexă de hidrocarburi produsă printr-un proces de cracare cu vapori. Constă cu precădere în hidrocarburi având numărul de atomi de carbon C4, predominând 1-butena şi 2-butena, conţinând de asemenea butan şi izobutan şi având punctul de fierbere cuprins între aproximativ minus 12°C şi 5°C (10.4°F şi 41°F). (mt)
C&L Inventory
ogljikovodiki, C4, destilat parnega krekinga (sl)
C&L Inventory
Ogļūdeņraži, C4, tvaika krekinga destilāti (lv)
C&L Inventory
Petroleumgas (nl)
C&L Inventory
Petroleumgas (sv)
C&L Inventory
petroleumsgass (no)
C&L Inventory
plini iz predelave zemeljskega olja (sl)
C&L Inventory
plyn zo spracovania ropy (sk)
C&L Inventory
Ropný plyn (cs)
C&L Inventory
Szénhidrogének, C4, gőzkrakkoló desztillátum (hu)
C&L Inventory
Süsivesinikud, C4, aurufaasilise krakkimisseadme destillaat (et)
C&L Inventory
Ugljikovodici, C4, destilat parnog krekinga (hr)
C&L Inventory
Uhlovodíky C4, pyrolyzní destilát (cs)
C&L Inventory
Węglowodory C4, destylaty z krakingu z parą wodną (pl)
C&L Inventory
Πετρελαϊκό αέριο (el)
C&L Inventory
Υυδρογονάνθρακες, C4 , απόσταγμα μονάδας ατμοπυρόλυσης (el)
C&L Inventory
Въглеводороди, C4, дестилат от паров крекинг (bg)
C&L Inventory
Нефтен газ (bg)
C&L Inventory
Hydrocarbons, C4, steam-cracker distillates
Other
Butylene (Member of: 92045-23-3 LOA Cat D)
Registration dossier
Butylenes
Registration dossier
C4 raffinate-1&2
Registration dossier
Hydrocarbons, C4, steam-cracked distillate
Registration dossier
Hydrocarbons, C4, steam-cracker distillate
C&L Inventory, Registration dossier
Hydrocarbons, C4, steam-cracker distillate
Registration dossier
Hydrocarbons, C4, steam-cracker distillates
Registration dossier
Hydrocarbons, C4, steam-craker distillate
Registration dossier
not applicable
Registration dossier
not applicible
Registration dossier
Raffinate 1
Registration dossier
raffinate 2
Registration dossier
Raffinate I/II
Registration dossier
Raffinate-1
Registration dossier
Reaction mass of butane and butene
C&L Inventory
Alkenes (Chemical Category)
Registration dossier
Butane
Registration dossier
Butylene crude
Registration dossier
BUTYLENE-E
Registration dossier
C4 raffinate 1
Registration dossier
C4 raffinate 2
Registration dossier
Fuel gases (Chemical Category)
Registration dossier
Hydrocarbons, (C = 4), steam-cracker distillate
Registration dossier
Hydrocarbons, C4, steam-cracker distillate
Registration dossier
Kohlenwasserstoffe, C4-, Dampfkracker Destillat
Registration dossier
Not Applicable
Registration dossier
Raffinat 1
Registration dossier
Raffinate 1
Registration dossier
Raffinate 1 (extracted)
Registration dossier
Raffinate 1 (hydrogenated)
Registration dossier
Raffinate 1 C4 spent
Registration dossier
Raffinate 1 hydrogenated
Registration dossier
Raffinate 2
Registration dossier
RAFFINATE-1
Registration dossier
649-116-00-9
Index number
C&L Inventory
92045-23-3
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 17 studies submitted
  • 16 studies processed
C Physical state at 20°C and 1013 hPa
Gaseous (100%) [16]
C Form
Liquified gas (94%) [16]
C Odour
Odourless (56%), Other (25%), Sweetish (19%) [16]
C Substance type
Petroleum product (56%), Organic (44%) [16]

Type of Study provided
Studies with data
Key study 14 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Gaseous (67%), Liquid (33%)
Form
Gas under pressure: liquefied gas (100%)

Melting/freezing point

Study results
  • 22 studies submitted
  • 21 studies processed
R Melting / freezing point
-185.34 - -93.11 °C @ 101.3 - 101.325 kPa [23]

Type of Study provided
Studies with data
Key study 5 4 12
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-144.8 - -109.15 °C

Boiling point

Study results
  • 22 studies submitted
  • 21 studies processed
R Boiling point
-11.73 - 10.9 °C @ 101.3 kPa [21]

Type of Study provided
Studies with data
Key study 5 4 12
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
-4.15 - -3.27 °C

Density

Study results
  • 15 studies submitted
  • 14 studies processed
R Density
0.56 - 0.62 g/cm³ @ 20 - 25 °C [8]
R Relative density
0.57 - 0.62 @ 20 - 25 °C [6]

Type of Study provided
Studies with data
Key study 6 8
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Relative density at 20°C
0.594

Vapour pressure

Study results
  • 16 studies submitted
  • 9 studies processed
R Vapour pressure
100 - 1 750 kPa @ -12 - 25 °C [13]

Type of Study provided
Studies with data
Key study 9
Supporting study 5
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Vapour pressure
217 - 963 kPa @ 17 - 25 °C

Partition coefficient

Study results
  • 14 studies submitted
  • 12 studies processed
R Log Pow
1.398 - 2.89 @ 20 - 25 °C and pH 7 [12]

Type of Study provided
Studies with data
Key study 7 3 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
1.99 - 2.35 @ 20 °C

Water solubility

Study results
  • 19 studies submitted
  • 17 studies processed
R Water solubility (mass/vol.)
53.5 - 2 837.9 mg/L @ 20 - 30 °C and pH 7 [17]

Type of Study provided
Studies with data
Key study 6 3 8
Supporting study 1 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Water solubility
190.1 - 735 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 13 studies submitted
  • 12 studies processed
R Autoflammability / self-ignition
324 - 465 °C @ 101.3 kPa [12]

Type of Study provided
Studies with data
Key study 4 8
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
385 °C

Flammability

Study results
  • 13 studies submitted
  • 12 studies processed
C Interpretation of results
Extremely flammable (100%) [12]

Type of Study provided
Studies with data
Key study 4 8
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Flammability
Extremely flammable (50%), Flammable (50%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 17 studies submitted
  • 15 studies processed
R Dissipation half life (DT50)
3.864 - 151.2 h [17]

Type of Study provided
Studies with data
Key study 4 1 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Half life in air
50.88 - 57.6 h

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 37 studies submitted
  • 6 studies processed
C Interpretation of results
Readily biodegradable (100%) [6]

Type of Study provided
Studies with data
Key study 2
Supporting study 17
Weight of evidence 2 9 7
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Biodegradation in water
Readily biodegradable (50%), Under test conditions no biodegradation observed (50%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 14 studies submitted
  • 9 studies processed
R log Koc
1.21 - 2.51 dimensionless [18]

Type of Study provided
Studies with data
Key study 9
Supporting study 1 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 13 studies submitted
  • 12 studies processed
R H - (pressure) m³/mol
1 956 - 103 352 Pa m³/mol @ 25 °C and 101.3 - 101.325 kPa [22]

Type of Study provided
Studies with data
Key study 9 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Henry's law constant
39 840 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (3)
Intermittent releases (freshwater) No hazard identified (3)
Marine water No hazard identified (3)
Intermittent releases (marine water) No hazard identified (3)
Sewage treatment plant (STP) No hazard identified (3)
Sediment (freshwater) No hazard identified (3)
Sediment (marine water) No hazard identified (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil No hazard identified (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (3)

Short–term toxicity to fish

Study results
  • 18 studies submitted
  • 11 studies processed
P/RResults
LC50 (4 days) 19 - 148.62 mg/L [11]

Type of Study provided
Studies with data
Key study 9 2
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 18 studies submitted
  • 11 studies processed
P/RResults
LC50 (48 h) 11 - 79.823 mg/L [11]

Type of Study provided
Studies with data
Key study 9 2
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 11 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 17 studies submitted
  • 11 studies processed
P/RResults
EC50 (4 days) 7.7 - 47.248 mg/L [11]

Type of Study provided
Studies with data
Key study 9 2
Supporting study 1 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
7.7 - 12.405 mg/L
EC10 or NOEC for freshwater algae
3.459 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 769 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 769 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 163 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 229.4 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 27 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 9 6
Supporting study 3 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 1 summary processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
inhalation
  • 31 studies submitted
  • 10 studies processed
P/RResults
LC50 (2 h) 1 237 mg/L air (mouse) [3]
LC50 (2 h) 520 400 - 539 600 ppm (mouse) [4]
M/CInterpretations of results
Not classified [10]

inhalation
Studies with data
Key study 6 4
Supporting study 5 10
Weight of evidence 2 2
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: eye
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Study data: respiratory
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
M/C Summaries
  • 4 summaries submitted
  • 1 summary processed
Skin sensitisation
No study available
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 6 studies submitted
  • 3 studies processed
P/RResults
NOAEL (rat): 148.6 mg/kg bw/day [3]

Type of Study provided
Study data: oral
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Study data: inhalation
  • 41 studies submitted
  • 14 studies processed
P/RResults
NOAEC (rat): 21.394 mg/L air [6]
NOAEC (rat): 9 000 - 10 000 ppm [8]
NOAEC (mouse): 10 000 ppm [2]
LOAEC (rat): 5 000 ppm [1]
LOAEC (mouse): 5 000 ppm [1]

Study data: inhalation
Studies with data
Key study 17 12
Supporting study 2 4
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 4 summaries submitted
  • 2 summaries processed
Inhalation route - systemic effects:
Adverse effect observed NOAEC 2 212 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 4 589 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 51 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 26 20
Supporting study 1 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: in vivo
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 11 2
Supporting study 2 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 6 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 25 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 6 8
Supporting study 2 4
Weight of evidence
Other 3
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: developmental
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 8 2
Supporting study 4 6
Weight of evidence
Other 6
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 2 summaries processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 13 276 mg/m³ (subacute, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 18 359 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant