Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
295-279-0
CAS no.:
91995-18-5
Index number:
Molecular formula:
C16H20
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
6
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may be fatal if swallowed and enters airways, may cause genetic defects and may cause cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects, is an extremely flammable liquid and vapour, is suspected of damaging fertility or the unborn child, may cause drowsiness or dizziness and causes skin irritation.

Breakdown of all 45 C&L notifications submitted to ECHA

STOT SE 3 H336
Asp. Tox. 1 H304 Harmonised Classification
Aquatic Chronic 2 H411
Skin Irrit. 2 H315
Repr. 2 H361
Muta. 1B H340 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Flam. Liq. 1 H224
Flam. Liq. 2 H225
Flam. Liq. 3 H226
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (28.89% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (28.89% of REACH registrations).

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 5 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels, air care products, anti-freeze products, coating products, lubricants and greases, washing & cleaning products and welding & soldering products.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, in materials as fuel sources, with limited exposure to unburned product to be expected, batch processing in synthesis or formulation with opportunity for exposure, roller or brushing applications, non-industrial spraying and treatment of articles by dipping and pouring.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and rubber products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites, as processing aid, of substances in closed systems with minimal release, in the production of articles, as processing aid and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep away from heat, sparks, open flames and/or hot surfaces – No smoking; obtain special instructions before use; avoid release to the environment; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: If swallowed: immediately call a poison center or doctor/physician. Do not induce vomiting.

Storage statements

Store this substance in a well-ventilated place and keeping container tightly closed.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • BP Europa SE, Überseeallee 1 20457 Hamburg Germany
  • OMV PETROM S.A., 22 Coralilor Street (“Petrom City”) Sector 1 013329 Bucharest Romania
  • PCK RAFFINERIE GMBH, Passower Chaussee 111 16303 Schwedt/Oder Germany
  • Ruhr Oel GmbH, Pawiker Strasse 30 45896 Gelsenkirchen Germany
  • Shell Deutschland Oil GmbH, Suhrenkamp 71-77, 22335 Hamburg Germany

Substance names and other identifiers

Aromatic hydrocarbons, C8, catalytic reforming-derived
EC Inventory, C&L Inventory, REACH pre-registration, Other, EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels
Aromatic hydrocarbons, C8, catalytic reforming-derived; Low boiling point cat-reformed naphtha
EU. Worker Protection-Hazardous (98/24), EU. Carcinogens/Mutagens Directive (2004/37), EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Young People at Work (94/33)
Low boiling point cat-reformed naphtha
C&L Inventory, EU. Dangerous Substances - Eco-Labels
Alacsony forráspontú kat-reformált benzin (hu)
C&L Inventory
Aromaatsed süsivesinikud, C8, katalüütilise reformingu derivaadid (et)
C&L Inventory
Aromaattiset hiilivedyt, C8, katalyyttisellä reformoinnilla johdettu (fi)
C&L Inventory
aromatické C8-uhľovodíky, z katalytického zušľachťovania (sk)
C&L Inventory
Aromatické uhlovodíky, C8, z katalytického reformování (cs)
C&L Inventory
Aromatiniai angliavandeniliai, C8, gauti vykdant katalizinį riformingą (lt)
C&L Inventory
Aromatische Kohlenwasserstoffe, C8, durch katalytisches Reformieren (de)
C&L Inventory
Aromatische koolwaterstoffen, C8-, afkomstig uit katalytische reforming (nl)
C&L Inventory
Aromatiska kolväten, C8-, från katalytisk reformering (sv)
C&L Inventory
aromatiske carbonhydrider, C8-, katalytisk reformeringsudvundne (da)
C&L Inventory
aromatiske hydrokarboner, C8, utvunnet ved katalytisk reformering (no)
C&L Inventory
aromatski ogljikovodiki, C8, pridobljeni s katalitskim reformingom (sl)
C&L Inventory
Aromatski ugljikovodici, C8, dobiveni kat. reformiranjem (hr)
C&L Inventory
Aromás szénhidrogének, C8, katalitikus reformálásból származó (hu)
C&L Inventory
Aromātiskie ogļūdeņraži, C8, katalītiskā riforminga produkti (lv)
C&L Inventory
Hidrocarbonetos aromáticos, C8, derivados de reformação catalítica (pt)
C&L Inventory
Hidrocarburi aromatice, fracţia C8, derivaţi de reformare catalitică (mt)
C&L Inventory
hidrocarburos aromáticos, C8, derivados del reformado catalítico (es)
C&L Inventory
Hydrocarbures aromatiques en C8, dérivés du reformage catalytique (fr)
C&L Inventory
idrocarburi aromatici, C8, derivati da reforming catalitico (it)
C&L Inventory
katalitsko reformirana nafta z nizko temperaturo vrelišča (sl)
C&L Inventory
katalyticky reformovaný ťažký benzín s nízkou teplotou varu (sk)
C&L Inventory
Katalytisch gereformde nafta met laag kookpunt (nl)
C&L Inventory
katalytisch reformiertes Naphtha, niedrigsiedend (de)
C&L Inventory
Katalītiski riformēts ligroīns ar zemu viršanas temperatūru (lv)
C&L Inventory
Lavtkogende katalytisk reformeret nafta (da)
C&L Inventory
lavtkokende katalytisk reformert nafta (no)
C&L Inventory
Lågkokande katalytiskt reformerad nafta (sv)
C&L Inventory
Madala keemispunktiga katalüütiliselt reformitud raskbensiin (et)
C&L Inventory
Matalalla kiehuva katalyyttisesti reformoitu teollisuusbensiini (fi)
C&L Inventory
Nafta de baixo ponto de ebulição de reformação catalítica (pt)
C&L Inventory
Nafta de reformare catalitică cu punct de fierbere scăzut (mt)
C&L Inventory
nafta di reforming catalitico con basso punto di ebollizione (it)
C&L Inventory
nafta reformada catalíticamente de bajo punto de ebullición (es)
C&L Inventory
naphta de reformage catalytique à point d'ébullition bas (fr)
C&L Inventory
Nisko-vrijući kat. reformiran benzin (hr)
C&L Inventory
Niskowrząca benzyna z reformingu katalitycznego (pl)
C&L Inventory
Nízkovroucí katalyticky reformovaná benzínová frakce (cs)
C&L Inventory
Węglowodory aromatyczne C8, pochodne z reformingu katalitycznego (pl)
C&L Inventory
Žematemperatūris katalizinio riformingo pirminis benzinas (lt)
C&L Inventory
αρωματικοί υδρογονάνθρακες, C8, προερχόμενοι από καταλυτική αναμόρφωση (el)
C&L Inventory
Νάφθα χαμηλού σημείου ζέσεως από καταλυτική αναμόρφωση (el)
C&L Inventory
Ароматни въглеводороди, C8, получени от каталитичен реформинг (bg)
C&L Inventory
Нискооктанов бензин от каталитичен реформинг с ниска температура на кипене (bg)
C&L Inventory
649-310-00-3
Index number
C&L Inventory
91995-18-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, EU. Worker Protection-Hazardous (98/24), EU. Cosmetics Regulation, Annex II, Prohibited Substances, EU. Dangerous Substances - Eco-Labels, EU. Pregnant Women Protection (92/85), EU. Workplace Signs, EU. Hazardous Waste Properties: Annex III (2008/98/EC), EU. Carcinogens/Mutagens Directive (2004/37), EU. Young People at Work (94/33)

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 2 studies submitted
  • 2 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [2]
C Form
Other (100%) [2]
C Substance type
Petroleum product (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Melting/freezing point

Study results
  • 3 studies submitted
  • 1 study processed
R Melting / freezing point
-60 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 4 studies submitted
  • 2 studies processed
R Boiling point
-20 - 260 °C @ 101.325 kPa [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 2 studies submitted
  • 2 studies processed
R Relative density
0.62 - 0.88 @ 15 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 2 studies submitted
  • 2 studies processed
R Vapour pressure
240 kPa @ 37.8 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Partition coefficient

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Water solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 2 studies submitted
  • 2 studies processed
R Flash point
-40 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 8 studies submitted
  • 4 studies processed
R Autoflammability / self-ignition
280 - 470 °C @ 101.3 - 101.325 kPa [4]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 2 studies submitted
  • 2 studies processed
C Interpretation of results
Extremely flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 4 studies submitted
  • 2 studies processed
R kinematic viscosity (in mm²/s)
1 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 14 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 12
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 93.02 % [1]
R Water 5.83 % [1]
R Soil 0.34 % [1]
R Sediment 0.81 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (1)
Intermittent releases (freshwater) No data available: testing technically not feasible (1)
Marine water No data available: testing technically not feasible (1)
Intermittent releases (marine water) No data available: testing technically not feasible (1)
Sewage treatment plant (STP) No data available: testing technically not feasible (1)
Sediment (freshwater) No data available: testing technically not feasible (1)
Sediment (marine water) No data available: testing technically not feasible (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (1)
Hazard for Predators
Secondary poisoning Insufficient hazard data available (further information necessary) (1)

Short–term toxicity to fish

Study results
  • 32 studies submitted
  • 4 studies processed
P/RResults
LL50 (4 days) 8.2 - 10 mg/L [4]

Type of Study provided
Studies with data
Key study 4
Supporting study 28
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
EL50 (21 days) 10 mg/L [2]
NOELR (21 days) 2.6 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 24 studies submitted
  • 2 studies processed
P/RResults
EL50 (48 h) 4.5 mg/L [2]
NOELR (48 h) 500 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOELR (21 days) 2.6 - 16 mg/L [4]
EL50 (21 days) 10 - 40 mg/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 32 studies submitted
  • 2 studies processed
P/RResults
EL50 (4 days) 3.7 mg/L [2]
EL50 (72 h) 3.1 mg/L [2]
NOELR (72 h) 500 µg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 30
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
EC50 (40 h) 15.41 mg/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.9 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 286.4 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 837.5 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 1 066.67 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 410 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 152 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 178.57 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 640 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 87 studies submitted
  • 2 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study 1 1
Supporting study 45 40
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 79 studies submitted
  • 4 studies processed
M/CInterpretations of results
Not classified [4]

inhalation
Studies with data
Key study 3 1
Supporting study 36 39
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 89 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rabbit) [2]
M/CInterpretations of results
Not classified [2]

dermal
Studies with data
Key study 1 1
Supporting study 44 43
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 5 610 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 209 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study 116 90
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 90 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1 1
Supporting study 44 43
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin
Adverse effect observed (irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 86 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1
Supporting study 42 41
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 5 4
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 44 studies submitted
  • 2 studies processed
P/RResults
NOAEC (rat): 9.84 - 20 mg/L air [3]

Study data: inhalation
Studies with data
Key study 3 1
Supporting study 19 21
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 102 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 375 - 3 750 mg/kg bw/day [2]
NOEL (rabbit): 200 - 2 000 mg/kg bw/day [14]

Study data: dermal
Studies with data
Key study 9 1
Supporting study 43 49
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Inhalation route - systemic effects:
No adverse effect observed NOAEC 1 402 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 43 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2 3
Supporting study 19 18
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2 1
Supporting study 12 13
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 24 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 2
Supporting study 12 9
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 9 869 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 1
Supporting study 2 3
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1 2
Supporting study 7 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 20 000 mg/m³ (chronic, rat)
Effect on developmental toxicity
Dermal route:
No adverse effect observed NOAEL 500 mg/kg bw/day (subchronic, rat)
Inhalation route:
No adverse effect observed NOAEC 23 900 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 2 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant