Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
289-339-5
CAS no.:
87741-01-3
Index number:
Molecular formula:
C8H20
SMILES:
CCCC.CC(C)C
InChI:
InChI=1S/2C4H10/c1-4(2)3;1-3-4-2/h4H,1-3H3;3-4H2,1-2H3
Type of substance:
Multi constituent substance, UVCB
Origin:
Organic, Petroleum product
Registered compositions:
29
Of which contain:
1 impurities relevant for classification
1 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause genetic defects, may cause cancer and is an extremely flammable gas.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child, is harmful if inhaled, may cause damage to organs through prolonged or repeated exposure, is suspected of damaging fertility or the unborn child, is harmful to aquatic life with long lasting effects and contains gas under pressure and may explode if heated.

Breakdown of all 1012 C&L notifications submitted to ECHA

Flam. Gas 1 H220 Harmonised Classification
Press. Gas (Liq.) H280
Muta. 1B H340 Harmonised Classification
Repr. 1A H360
Acute Tox. 4 H332
Carc. 1A H350 Harmonised Classification
Carc. 1B H350
STOT RE 2 H373
Repr. 2 H361
Aquatic Chronic 3 H412
Press. Gas Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is broad agreement in that a majority of data submitters agree this substance is Carcinogenic (66.83% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is broad agreement in that a majority of data submitters agree this substance is Mutagenic (66.83% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (66.33% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 30 active registrations under REACH, 2 Joint Submission(s) and 1 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: fuels.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following products: fuels. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release, as an intermediate step in further manufacturing of another substance (use of intermediates), for thermoplastic manufacture and manufacturing of the substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Keep out of reach of children.

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use personal protective equipment as required.; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: In case of leakage eliminate all ignition sources. In case of leaking gas fire do not extinguish unless leak can be stopped safely. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing.

Storage statements

Store this substance protected from sunlight and in a well-ventilated place.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ARLANXEO Elastomères France SAS, Zone Industrielle de Port Jérôme B.P. 80041 76170 Lillebonne France
  • Basell Polyolefine Gmbh, Bruhler strasse 60 D-50389 Wesseling Germany
  • BAYERNOIL Raffineriegesellschaft mbH, Postfach 1252 93328 Neustadt Bavaria Germany
  • BP Oil International, Chertsey Road TW16 7BP Sunbury on Thames Middlesex United Kingdom
  • BP Raffinaderij Rotterdam B.V., d'Arcyweg 76 3198 NA Europoort Rotterdam Netherlands
  • Efremov Kautschuk GmbH, Mergenthaler Allee 10-12 65760 Eschborn Germany
  • Esso Raffinage S.A.S., 20 Rue Paul Heroult 92000 Nanterre France
  • GAZPROM MARKETING AND TRADING FRANCE 24, 68 avenue des Champs Elysées 75008 PARIS France
  • Gunvor Petroleum Antwerpen NV, Scheldelaan 490 2040 Antwerp Belgium
  • Gunvor Raffinerie Ingolstadt GmbH, Essostrasse 1 85092 Kösching Germany
  • LUKOIL Neftohim Burgas AD, Western Industrial Zone 8104 Bourgas Bulgaria
  • MOL Hungarian Oil and Gas Public Limited Company, Oktober huszonharmadika 18 1117 Budapest Hungary
  • MOTOR OIL (HELLAS) CORINTH REFINERIES S.A., Irodou Attikou 12a 15124 Marousi Athens Greece
  • OMV Deutschland Operations GmbH & Co.KG, Haiminger Straße 1 D-84489 Burghausen Germany
  • OMV Downstream GmbH, Trabrennstraße 6-8 A-1020 Wien Austria
  • OMV PETROM S.A., 22 Coralilor Street (“Petrom City”) Sector 1 013329 Bucharest Romania
  • PCK RAFFINERIE GMBH, Passower Chaussee 111 16303 Schwedt/Oder Germany
  • Petroplus Raffinage Petit Couronne SAS, Rue Aristide Briand 72 76650 Petit Couronne France
  • Petroplus Raffinage Reichstett SAS, Route Départementale 37 67116 Reichstett France
  • Petróleos de Portugal - Petrogal, S.A., Rua Tomás da Fonseca, Torres de Lisboa, Torre C 1600-209 Lisboa Portugal
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Ruhr Oel GmbH, Pawiker Strasse 30 45896 Gelsenkirchen Germany
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • SARLUX srl, S.S. Sulcitana 195 km. 19 09018 Sarroch (CA) Sardinia Italy
  • SC Rompetrol Rafinare SA, Navodari Street no.215, Administrative Building 905700 Navodari Constanta Romania
  • SLOVNAFT, a.s., Vlcie hrdlo 1 824 12 Bratislava Slovakia
  • Société Francaise du Pipe Line du Jura, 6 Place de la Madeleine 75008 Paris France
  • Total Raffinage France, 2, place Jean Millier, La Défense 92400 Courbevoie France
  • Unipetrol RPA, Litvinov - Zaluzi 1 43670 Litvinov Czech Republic
  • BASF Antwerpen N.V., Haven 725, Scheldelaan 600 2040 Antwerpen 4 Antwerpen Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Petroplus Refining and Marketing Limited, Coryton Refinery The Manorway SS17 9LL Stanford-le-Hope Essex United Kingdom

Substance names and other identifiers

Hydrocarbons, C4
EC Inventory, C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures
Hydrocarbons, C4; Petroleum gas
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
Petroleum gas
C&L Inventory, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures
Angliavandeniliai, C4 (lt)
C&L Inventory
C4-uhľovodíky (sk)
C&L Inventory
carbonhydrider, C4- (da)
C&L Inventory
gas di petrolio (it)
C&L Inventory
Gase aus der Erdölverarbeitung (de)
C&L Inventory
gases de petróleo (es)
C&L Inventory
gaz de pétrole (fr)
C&L Inventory
Gaz petrolier (mt)
C&L Inventory
Gaz z ropy naftowej (pl)
C&L Inventory
Gás de petróleo (pt)
C&L Inventory
Hidrocarbonetos, C4 (pt)
C&L Inventory
Hidrocarburi cu C4 (mt)
C&L Inventory
hidrocarburos, C4 (es)
C&L Inventory
Hiilivedyt, C4 (fi)
C&L Inventory
Hydrocarbures en C4; gaz de pétrole; (fr)
C&L Inventory
hydrokarboner, C4- (no)
C&L Inventory
idrocarburi C4 (it)
C&L Inventory
Kohlenwasserstoffe, C4 (de)
C&L Inventory
Kolväten, C4- (sv)
C&L Inventory
Koolwaterstoffen, C4- (nl)
C&L Inventory
Kulbrintegasser (da)
C&L Inventory
Kőolaj gáz (hu)
C&L Inventory
Maaöljykaasu (fi)
C&L Inventory
Naftagaas (et)
C&L Inventory
Naftas gāze (lv)
C&L Inventory
Naftni plin (hr)
C&L Inventory
Naftos dujos (lt)
C&L Inventory
ogljikovodiki, C4 (sl)
C&L Inventory
Ogļūdeņraži, C4 (lv)
C&L Inventory
Petroleumgas (nl)
C&L Inventory
petroleumsgass (no)
C&L Inventory
plini iz predelave zemeljskega olja (sl)
C&L Inventory
plyn zo spracovania ropy (sk)
C&L Inventory
Ropný plyn (cs)
C&L Inventory
Szénhidrogének, C4 (hu)
C&L Inventory
Süsivesinikud, C4 (et)
C&L Inventory
Ugljikovodici, C4 (hr)
C&L Inventory
Uhlovodíky, C4; (cs)
C&L Inventory
Węglowodory, C4 (pl)
C&L Inventory
Πετρελαϊκό αέριο (el)
C&L Inventory
υδρογονάνθρακες, C4 (el)
C&L Inventory
Въглеводороди, C4 (bg)
C&L Inventory
Нефтен газ (bg)
C&L Inventory
2-methylpropane; butane
Other
Butan (Hydrocarbons, C4)
Registration dossier
Butan fraction
Registration dossier
butane-butene fraction
Registration dossier
HYDROCARBONS, C-4
C&L Inventory, Registration dossier
Butaan
Registration dossier
Butane
Registration dossier
BUTANE COMMERCIAL
Registration dossier
Butane high butadiene
Registration dossier
Butane incorrect / off spec
Registration dossier
Butane low butadiene
Registration dossier
Buten
Registration dossier
Butylene
Registration dossier
C4
Registration dossier
C4 fraction
Registration dossier
C4 frakce
Registration dossier
C4 hydrocarbons
Registration dossier
C4 LPG
Registration dossier
Cracked butane
Registration dossier
Cracked C4
Registration dossier
CrC4
Registration dossier
Gaz de Pétrole liquéfié
Registration dossier
Gaz liquéfié butane
Registration dossier
Hydrocarbons (Chemical Category)
Registration dossier
Hydrocarbons, C4 and C4-unsatd.
Registration dossier
Kohlenwasserstoffe, C4-
Registration dossier
LPG
Registration dossier
LPG, GPL
Registration dossier
Mercaptan Enriched C4
Registration dossier
Olefin
Registration dossier
Raffinat 2
Registration dossier
649-113-00-2
Index number
C&L Inventory
68476-41-5
Deleted CAS number
Other
87741-01-3
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
91052-97-0
Deleted CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 20 studies submitted
  • 19 studies processed
C Physical state at 20°C and 1013 hPa
Gaseous (100%) [19]
C Form
Liquified gas (94%) [16]
C Odour
Other (44%), Odourless (31%), Sweetish (13%) [16]
C Substance type
Petroleum product (63%), Organic (38%) [16]

Type of Study provided
Studies with data
Key study 9 10
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 8 studies processed
R Melting / freezing point
-187.6 - -105.52 °C @ 101.3 kPa [8]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-154.1 - -109.15 °C

Boiling point

Study results
  • 12 studies submitted
  • 7 studies processed
R Boiling point
-161.48 - 3.71 °C @ 101.3 - 101.325 kPa [7]

Type of Study provided
Studies with data
Key study 8
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
-4.15 - -2.1 °C

Density

Study results
  • 10 studies submitted
  • 6 studies processed
R Density
0.423 - 0.589 g/cm³ @ -89 - 25 °C [5]
R Relative density
0.57 - 0.75 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1 5
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Relative density at 20°C
0.6

Vapour pressure

Study results
  • 14 studies submitted
  • 4 studies processed
R Vapour pressure
100 - 1 160 kPa @ -7.3 - 25 °C [8]

Type of Study provided
Studies with data
Key study 2 2
Supporting study 6
Weight of evidence
Other 2 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
217 - 837.25 kPa @ 17 - 25 °C

Partition coefficient

Study results
  • 16 studies submitted
  • 10 studies processed
R Log Pow
1.09 - 2.8 @ 20 °C and pH 7 [10]

Type of Study provided
Studies with data
Key study 1 6 3
Supporting study 2
Weight of evidence
Other 1 3
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
1.99 - 2.28 @ 20 °C

Water solubility

Study results
  • 9 studies submitted
  • 7 studies processed
R Water solubility (mass/vol.)
24.4 - 792.3 mg/L @ 20 - 25 °C and pH 7 [7]

Type of Study provided
Studies with data
Key study 4 3
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
371.8 - 735 mg/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 12 studies submitted
  • 8 studies processed
R Flash point
-104 - -18 °C @ 101.3 kPa [8]

Type of Study provided
Studies with data
Key study 4 4
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Flash point at 101 325 Pa
-26 °C

Auto flammability

Study results
  • 13 studies submitted
  • 10 studies processed
R Autoflammability / self-ignition
287 - 537 °C @ 99.1 - 102.1 kPa [10]

Type of Study provided
Studies with data
Key study 4 6
Supporting study 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
384 °C

Flammability

Study results
  • 10 studies submitted
  • 8 studies processed
C Interpretation of results
Extremely flammable (100%) [8]

Type of Study provided
Studies with data
Key study 8
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 6 studies submitted
  • 6 studies processed
R Dissipation half life (DT50)
3.864 - 45 744 h [8]

Type of Study provided
Studies with data
Key study 2 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
50.88 h

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 23 studies submitted
  • 11 studies processed
C Interpretation of results
Readily biodegradable (100%) [11]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 6 7
Other 6
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (67%), Readily biodegradable (33%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 3 studies processed
R H - (pressure) m³/mol
7 150 - 98 200 Pa m³/mol @ 25 °C and 101.3 kPa [6]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Henry's law constant
39 840 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 1 8
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (1)
Intermittent releases (freshwater) No data available: testing technically not feasible (1)
Marine water No data available: testing technically not feasible (1)
Intermittent releases (marine water) No data available: testing technically not feasible (1)
Sewage treatment plant (STP) No data available: testing technically not feasible (1)
Sediment (freshwater) No data available: testing technically not feasible (1)
Sediment (marine water) No data available: testing technically not feasible (1)
Hazard for Air
Air Hazard related to composition of atmosphere identified (1)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 16 studies submitted
  • 6 studies processed
P/RResults
LC50 (4 days) 24.11 - 147.54 mg/L [5]
LL50 (4 days) 45.7 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 10
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
45.7 mg/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
LC50 (48 h) 14.22 - 69.43 mg/L [5]
LL50 (48 h) 79.51 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
79.51 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
EC50 (4 days) 7.71 - 16.5 mg/L [5]
EL50 (72 h) 33.6 mg/L [1]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other 4
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
33.6 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1 g/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 4 summaries submitted
  • 4 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: DNEL
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 23.4 mg/kg bw/day carcinogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 66.4 µg/m³ carcinogenicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 31 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 3 7
Supporting study 7
Weight of evidence
Other 12
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
oral
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons. 1
Other
inhalation
  • 37 studies submitted
  • 8 studies processed
P/RResults
LC50 (15 min) 1 442.738 - 1 443 mg/L air (rat) [2]
LC50 (15 min) 800 000 ppm (rat) [1]
LC50 (2 h) 1 237 mg/L air (mouse) [2]
LC50 (2 h) 520 400 - 539 600 ppm (mouse) [3]
M/CInterpretations of results
Not classified [8]

inhalation
Studies with data
Key study 3 5
Supporting study 11
Weight of evidence 6
Other 1 11
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence
Other 2
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 1
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Skin sensitisation
No study available
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 3 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 148.6 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Study data: inhalation
  • 54 studies submitted
  • 19 studies processed
P/RResults
NOAEC (rat): 7.214 - 21.394 mg/L air [6]
NOAEC (rat): 4 000 - 16 000 ppm [10]
NOAEC (mouse): 10 000 ppm [3]
LOAEC (rat): 21.641 mg/L air [1]
LOAEC (rat): 5 000 - 12 000 ppm [3]

Study data: inhalation
Studies with data
Key study 10 16
Supporting study 5
Weight of evidence
Other 1 20
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Inhalation route - systemic effects:
Adverse effect observed NOAEC 2 212 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 44 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 12 22
Supporting study 1
Weight of evidence
Other 9
Data waiving
no waivers
Study data: in vivo
  • 31 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 9 7
Supporting study 4
Weight of evidence
Other 11
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 9
Supporting study 2
Weight of evidence
Other 8
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 2 9
Supporting study 2
Weight of evidence 4
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: developmental
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3 9
Supporting study 4
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: other studies
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 13 276 mg/m³ (subacute, rat)

Neurotoxicity

Study results
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 6
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant