Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
273-761-1
CAS no.:
69012-64-2
Index number:
Molecular formula:
O2Si
SMILES:
O=[Si]=O
InChI:
InChI=1S/O2Si/c1-3-2
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
23
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance may cause damage to organs through prolonged or repeated exposure.

Breakdown of all 340 C&L notifications submitted to ECHA

Not Classified
STOT RE 2 H373
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

Nanomaterial form

Substance is known to be on the EEA market in nanomaterial form, as indicated in the REACH registered substance factsheet(s), and as listed in the EUON Nanomaterials in the EU market list.

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 48 active registrations under REACH, 1 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:
Nanomaterials in the EU Market

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: adhesives and sealants.

Other release to the environment of this substance is likely to occur from: outdoor use.

This substance is used in the following activities or processes at workplace: open transfer and processing with minerals/metals at elevated temperature, production of mixtures or articles by tabletting, compression, extrusion or pelletisation, the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding) and potentially closed industrial processing with minerals/metals at elevated temperature (e.g. smelters, furnaces, refineries, coke ovens).

Release to the environment of this substance can occur from industrial use: formulation in materials, in the production of articles and for thermoplastic manufacture.

This substance can be found in complex articles, with no release intended: machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines), vehicles and electrical batteries and accumulators. This substance can be found in products with material based on: rubber (e.g. tyres, shoes, toys), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper) and stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).

This substance is used in the following products: fillers, putties, plasters, modelling clay, adhesives and sealants, coating products, metals, polymers and washing & cleaning products.

This substance is used in the following areas: formulation of mixtures and/or re-packaging and building & construction work. This substance is used for the manufacture of: metals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes and hand mixing with intimate contact only with personal protective equipment available.

Release to the environment of this substance can occur from industrial use: in the production of articles, formulation of mixtures, formulation in materials, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and for thermoplastic manufacture. Other release to the environment of this substance is likely to occur from: outdoor use and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay and pH regulators and water treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation in materials and in the production of articles.

This substance is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay, fertilisers and pH regulators and water treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: mining. This substance is used for the manufacture of: mineral products (e.g. plasters, cement), rubber products, plastic products and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed batch processing in synthesis or formulation, transfer of substance into small containers and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation in materials and in the production of articles. Other release to the environment of this substance is likely to occur from: outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AGC Flat Glass Czech, Sklarska 450 416 74 Teplice Czech Republic
  • ASK Chemicals Metallurgy GmbH, Fabrikstraße 6 84579 Unterneukirchen Bayern Germany
  • AZ tech srl, Nucleo Tagliata, 43 12035 Racconigi (CN) Italy
  • Bernard_Spinoit, Bd Dewandre 13 6000 Charleroi Belgium
  • Cofermin Rohstoffe GmbH & Co. KG, Alfredstrasse 61 45130 Essen Germany
  • CS3 GmbH, Grauertstrasse 12 81545 München Germany
  • Dow Silicones Belgium SPRL OR-15, PSRC - Rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-4, PSRC - rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Dow Silicones Belgium SPRL OR-7, PSRC - rue Jules Bordet Zone industrielle C 7180 Seneffe Belgium
  • Elkem ASA, Drammensveien 169 0277 Oslo Norway
  • Elkem Iceland Ltd, Grundartangi, Skilmannahreppur IS-301 Akranes Iceland
  • FERROATLANTICA DE SABON, SLU, PASEO DE LA CASTELLANA 259D 49 28046 MADRID Spain
  • FERROPEM, 517 avenue de la Boisse 73000 Chambéry France
  • Finnfjord AS, Ferroveien 1 9300 Finnsnes Troms Norway
  • Fosbel GmbH, Karstrasse 116 41068 Mönchengladbach Germany
  • Grupo FerroAtlántica, S.A.U., Paseo de la Castellana 259D, planta 49 28046 Madrid Spain
  • Huta Łaziska S.A., Cieszyńska 23 43-170 Łaziska Górne silesia Poland
  • Höganäs Belgium SA, Ruelle Gros Pierre 10 B-7800 Ath Belgium
  • HÜTTENES-ALBERTUS Chemische Werke GmbH, Wiesenstrasse 23 40549 Düsseldorf Germany
  • IMCD Italia S.p.A., Via G. Spadolini 5 20141 Milano Italy
  • Imerys Fused Minerals Laufenburg GmbH, Ferroweg 1 79725 Laufenburg Baden Germany
  • Interalloys-RFA Ltd., Corner Spyrou Araouzou & Koumandarias Str Tonia Court Two, 7th flr, 3036 Limassol Cyprus Cyprus
  • Intertek Deutschland GmbH 87, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • ITACA, S.A., Partida Rambleta s/n 12191 Pobla Tornesa Castellón Spain
  • Merck KGaA, Frankfurter Strasse 250 64293 Darmstadt Germany
  • Metalleghe S.p.A., E. Fermi 12-14 25020 Flero Brescia Italy
  • OFZ,a.s., Široká 381 02741 Oravský Podzámok 36389030 Slovakia
  • Only representative (No publishable name), null
  • PCC BakkiSilicon hf, Bakkavegur 2 640 Husavik Iceland
  • PH-Consult & Trading A/S, Rentemestervej 39 2400 København NV Denmark
  • Possehl Erzkontor GmbH & Co. KG, Beckergrube 38-52 23552 Lübeck Germany
  • RE ALLOYS Sp. z o. o., Cieszyńska 23 43-170 Łaziska Górne Poland
  • REC Solar Norway AS, Vaagsbygd NO-4675 Kristiansand Norway
  • RHI Magnesita Distribution B.V., Hofplein 19 3032AC Rotterdam Netherlands
  • RHI Magnesita GmbH, Kranichberggasse 6 1120 Vienna Austria
  • RW silicium GmbH, Woehlerstr. 30 94060 Pocking Germany
  • SEPR, BP 60025 Route de Lyon 84131 le pontet cedex France
  • SEPR, BP 60025 Route de Lyon 84131 Le Pontet cedex France
  • Shandong Dongyue Silicon Mat. Co.Ltd. by OR Likedeelers GmbH, Hallbergstr. 10 40239 Düsseldorf NRW Germany
  • Sicerma GmbH, Lauerstraße 17 41812 Erkelenz Germany
  • solvadis specialties gmbh, Königsbergerstr. 1 60487 Frankfurt am Main Germany
  • TROPAG Oscar H. Ritter Nachf. GmbH, Bundesstrasse 4 20146 Hamburg Hamburg Germany
  • Vargön Alloys AB, -- 468 80 Vargön Sweden
  • Vesuvius Poland Sp. z o.o., ul. Tyniecka 12 32-050 Skawina Poland
  • Wacker Chemicals Norway A.S., Hollaveien 482 7200 Kyrksæterøra Hemne Norway
  • Xallas Electricidad Y Aleaciones, S.A. , C/Velázquez, nº 11, 1º Izda 28001 Madrid Spain
  • Ziegler & Co. GmbH, Dr.-Heinrich-Hohenner.Str. 4 95632 Wunsiedel Germany
  • FESIL SALES GmbH, Schifferstrasse 196 D-47059 Duisburg Germany
  • PH-Consult & Trading A/S, Rentemestervej 39 2400 København NV Denmark
  • Ramboll Deutschland GmbH, Werinherstraße 79 Gebäude 32 a 81541 München Germany
  • Serwin Holding ApS, Axel Kiers Vej 30 8270 Højbjerg Denmark

Substance names and other identifiers

Amorphous silica fume
Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
Other
Fumes, silica
EC Inventory, Other
Fumes, silica
Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
REACH pre-registration, Other
Silica, amorphous-fume
Amorphous silicon dioxide particles from the volatilization and vaporization of furnace feed materials in the manufacture of ferrosilicon and silicon.
Other
Fumes, silica
Other
273-761-1/Silica Fume
Registration dossier
Ferrosilicium, Iron silicide, Silica fume
Registration dossier
Fumed silica
Registration dossier
Fumes, Silica
C&L Inventory, Registration dossier
Fumes, Silica
C&L Inventory, Registration dossier
Kiselstoft
Registration dossier
Microsilica
Registration dossier
Silanedione
Registration dossier, Other
silca
C&L Inventory
Silica (amorphous)
C&L Inventory
Silica Fume
Registration dossier
Silica Fume of Re Alloys
Registration dossier
Silica Fumes
Registration dossier
silicium dioxide, amorphous
C&L Inventory
Silicon dioxide
C&L Inventory, Registration dossier
Silicon dioxide, amorphous
C&L Inventory, Registration dossier
Sillicon dioxide, amorphous
Registration dossier
Amorphous silica
Registration dossier
Dow Corning SM Silica Fume Product Number 4070944
Registration dossier
Elkem Microsilica
Registration dossier
Fesil Microsilica
Registration dossier
FeSilur
Registration dossier
Fumes, silica
Registration dossier
Micro Silica
Registration dossier
Microblock
Registration dossier
MICROFUME
Registration dossier
MICROFUME PELLETS
Registration dossier
Microsil
Registration dossier
Microsilica
Registration dossier
Microsilica condensed
Registration dossier
Microsilica FS
Registration dossier
Microsilica-Sioxid
Registration dossier
Mivasil
Registration dossier
RW-Compasil
Registration dossier
RW-Flusil
Registration dossier
RW-Füller
Registration dossier
Sicersil
Registration dossier
SIDISTAR
Registration dossier
Silica
Registration dossier
Silica fume
Registration dossier
Silica Fume (SIF-B-T)
Registration dossier
SILIMIC
Registration dossier
slurry
Registration dossier
69012-64-2
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 3 studies submitted
  • 3 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [3]
C Form
Powder (100%) [3]
C Odour
Odourless (100%) [3]
C Substance type
Inorganic (100%) [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 3 studies submitted
  • 3 studies processed
R Melting / freezing point
1 500 - 1 700 °C @ 101.3 - 101.325 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
1 705 °C

Boiling point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Density

Study results
  • 3 studies submitted
  • 3 studies processed
R Bulk density
0.45 - 0.67 g/cm³ @ 20 °C [2]
R Density
2.2 - 2.3 g/cm³ [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.45 - 0.67

Vapour pressure

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Partition coefficient

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Water solubility

Study results
  • 4 studies submitted
  • 2 studies processed
R Water solubility (mass/vol.)
110 - 160 mg/L @ 37 °C and pH 7.1 - 7.4 [2]

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
135 mg/L @ 37 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
6 - 6.65 @ 40 °C [6]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No hazard identified (3)
Intermittent releases (freshwater) No hazard identified (3)
Marine water No data: aquatic toxicity unlikely (2)
Intermittent releases (marine water) No data: aquatic toxicity unlikely (2)
Sewage treatment plant (STP) No data: aquatic toxicity unlikely (2)
Sediment (freshwater) No hazard identified (3)
Sediment (marine water) No hazard identified (3)
Hazard for Air
Air No hazard identified (3)
Hazard for Terrestrial Organism
Soil No hazard identified (3)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (3)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 100 mg/L [1]
LL0 (4 days) 10 g/L [2]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 3 studies processed
P/RResults
EC50 (24 h) 1.003 g/L [1]
EL50 (24 h) 1 g/L [2]
EL0 (24 h) 1 g/L [2]

Type of Study provided
Studies with data
Key study 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
NOEC (21 days) 100 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
EC50 (72 h) 4.2 g/L [1]
NOEC (72 h) 323 mg/L [1]
EC10 (72 h) 1.2 g/L [1]
EL50 (72 h) 10 g/L [2]
NOELR (72 h) 10 g/L [2]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for freshwater algae
250 mg/L
EC50 for marine water algae
1 g/L
EC10 or NOEC for freshwater algae
228 mg/L
EC10 or NOEC for marine water algae
323 mg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
EC50 (20 h) 5 g/L [2]
EC100 (20 h) 5 g/L [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 3 studies submitted
  • 1 study processed
P/RResults
LC50 (10 days) 50 566 mg/kg sediment dw [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater sediment
50 000 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
49 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: (DNEL) 300 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: No hazard identified
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence 10 11
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
No bioaccumulation potential

Acute toxicity

Study results
oral
  • 5 studies submitted
  • 4 studies processed
P/RResults
LD50 5 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Practically nontoxic [3]

Type of Study provided
oral
Studies with data
Key study 1 2
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
inhalation
  • 4 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 h) 2.08 mg/L air (rat) [3]
LC0 (4 h) 139 - 691 mg/m³ air (rat) [6]
M/CInterpretations of results
Practically nontoxic [3]

inhalation
Studies with data
Key study 2
Supporting study
Weight of evidence 1 1
Other
Data waiving
no waivers
dermal
  • 4 studies submitted
  • 1 study processed
P/RResults
LD50 5 000 mg/kg bw (rabbit) [1]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study
Supporting study
Weight of evidence 1 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Inhalation route:
No adverse effect observed LC50 140 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2 2
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2 2
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 5 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 4 000 - 8 980 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study
Weight of evidence 1 1 1
Other
Data waiving
no waivers
Study data: inhalation
  • 19 studies submitted
  • 11 studies processed
P/RResults
NOAEL (rat): 1 - 46 mg/m³ air [15]
LOAEL (rat): 53 mg/m³ air [1]
LOAEL (guinea pig): 53 mg/m³ air [3]
NOEL (rat): 10 mg/L air [1]

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence 9 1 8
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence 1
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 2 500 mg/kg bw/day (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 1.3 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 2
Supporting study
Weight of evidence 5 1 8
Other
Data waiving
no waivers
Study data: in vivo
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study
Weight of evidence 1 1 1
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 1
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: developmental
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 11 2
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant

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