Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
271-010-2
CAS no.:
68513-66-6
Index number:
649-087-00-2
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
4
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01corr) approved by the European Union, this substance may cause genetic defects, may cause cancer and is an extremely flammable gas.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may be fatal if swallowed and enters airways, is toxic to aquatic life with long lasting effects, may damage fertility or the unborn child, causes damage to organs through prolonged or repeated exposure, is harmful if inhaled, contains gas under pressure and may explode if heated and may cause drowsiness or dizziness.

Breakdown of all 18 C&L notifications submitted to ECHA

Flam. Gas 1 H220 Harmonised Classification
Press. Gas (Liq.) H280
STOT SE 3 H336
Asp. Tox. 1 H304
Repr. 1A H360
Carc. 1A H350 Harmonised Classification
Muta. 1B H340 Harmonised Classification
Aquatic Chronic 2 H411
Aquatic Chronic 3 H412
STOT RE 1 H372
Acute Tox. 4 H332
Muta. 1A H340
STOT RE 2 H373
Press. Gas Harmonised Classification
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (44.44% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (44.44% of REACH registrations).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (55.56% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 1 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Industrial accident prevention and reporting requirements have been established for this substance.
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels, air care products and coating products.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: closed, continuous processes with occasional controlled exposure, transfer of chemicals, transfer of substance into small containers, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), in processing aids at industrial sites and of substances in closed systems with minimal release.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; do not allow contact with air; do not breathe the dust, fume, gas, mist, vapours or spray; keep away from clothing or other combustible materials; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; do not eat, drink or smoke when using this product; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Call a poison center or doctor/physician if you feel unwell. In case of leakage eliminate all ignition sources. Get medical advice/attention if you feel unwell. In case of leaking gas fire do not extinguish unless leak can be stopped safely. If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Collect spillage. Do not induce vomiting. Follow specific treatment (see label).

Storage statements

Store this substance protected from sunlight; protected from sunlight and in a well-ventilated place; in a well-ventilated place; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Polski Koncern Naftowy ORLEN SA, ul. Chemików 7 09-411 Płock Poland

Substance names and other identifiers

[A complex residuum from the distillation of streams various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately – 11.7 °C to 27.8 °C (11 °F to 82 °F).]
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
C&L Inventory
Alkylation splitter bottoms
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
Other
Petroleum gas
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
C&L Inventory
Residues (petroleum), alkylation splitter, C4-rich
EC Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Residues (petroleum), alkylation splitter, C4-rich
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Residues (petroleum), alkylation splitter, C4-rich; Petroleum gas [ complex residuum from the distillation of streams various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately - 11.7 o C to 27.8 o C (11 °F to 82 °F).]
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Residues (petroleum), alkylation splitter, C4-rich; Petroleum gas
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
Residues, petroleum, alkylation splitter, C4-rich
A complex residuum from the distillation of streams from various refinery operations. It consists of hydrocarbons having carbon numbers in the range of C4 through C5, predominantly butane and boiling in the range of approximately -11.7°C to 27.8°C (11°F to 82°F).
Other
(Keerulise koostisega jääk, mis saadakse mitmesugustest rafineerimisoperatsioonidest pärinevate voogude destilleerimisel. Koosneb süsivesinikest süsiniku aatomite arvuga vahemikus C4 kuni C5, peamiselt butaanist, ning keeb temperatuuril vahemikus umbes –11,7°C -27,8 °C.) (et)
C&L Inventory
[A különféle finomítási műveletekből származó folyadékok desztillációjából nyert komplex maradék. Olyan szénhidrogénekből áll (főleg butánból), melyek szénatomszáma a C4-C5 tartományban van. Hozzávetőleges forráspont tartománya –11,7°C-tól 27,8°C-ig (11°F-től 82°F-ig) terjed.] (hu)
C&L Inventory
[Atlikums ar plašu sastāvu, iegūts, destilējot plūsmās ar dažādām attīrīšanas operācijām. Sastāv no ogļūdeņražiem ar oglekļa atomu skaitu no C4 līdz C5, galvenokārt no butāna, aptuvenā viršanas temperatūra -11.7°C līdz 27.8°C (11°F līdz 82°F).] (lv)
C&L Inventory
[Kompleks rest fra destillasjon av strømmer fra forskjellige raffineriprosesser. Består av hydrokarboner, C4 til C5, hovedsakelig butan, og har omtrentlig kokepunktsintervall fra -11,7 °C til 27,8 °C (11 °F til 82 °F).] (no)
C&L Inventory
[Kompleksen ostanek destilacije tokov iz različnih operacij v rafineriji. Sestoji iz ogljikovodikov s številom ogljikovih atomov v območju med C4 in C5, pretežno iz butana, ter ima vrelišče v območju približno med –11,7 °C in 27,8 °C.] (sl)
C&L Inventory
[komplexer Rückstand aus der Destillation von Läufen aus verschiedenen Raffinerievorgängen; besteht aus Kohlenwasserstoffen mit Kohlenstoffzahlen im Bereich von C4 bis C5, vorwiegend Butan, mit einem Siedebereich von etwa -11,7 °C bis 27,8 °C] (de)
C&L Inventory
[Komplexný zvyšok z destilácie materiálov z viacerých rafinérskych procesov. Pozostáva z uhľovodíkov s počtom atómov uhlíka prevažne v rozmedzí od C4 do C5, predovšetkým butánu. Má teplotu varu v rozmedzí približne od mínus 11,7 °C do 27,8 °C.] (sk)
C&L Inventory
[Složeni ostatak iz destilacije tokova različitih rafinerijskih operacija. Sastoji se od ugljikovodika koji imaju broj ugljikovih atoma u području C4 do C5, pretežito butan a vrije u području približno – 11,7 °C do 27,8 °C.] (hr)
C&L Inventory
[Složitý zbytek z destilace proudů z různých rafinérských operací. Je složen z uhlovodíků s počtem uhlíkových atomů v rozmezí C4 až C5, převážně butanu, s teplotou varu v rozmezí přibližně -11,7 °C až 27,8 °C.] (cs)
C&L Inventory
[Sudėtinis produktų, gautų įvairiuose naftos perdirbimo gamyklos procesuose, distiliavimo likutis. Jį sudaro angliavandeniliai, turintys anglies atomų skaičių nuo C4 iki C5, daugiausia butanas, ir kurių virimo temperatūra maždaug nuo −11,7 °C iki 27,8 °C (nuo 11 °F iki 82 °F).] (lt)
C&L Inventory
[Un reziduu complex rezultat prin distilarea produşilor diferitelor procese de rafinare. Constă în hidrocarburi al căror număr de atomi de carbon variază între C4 şi C5 , predominând butanul şi având punctul de fierbere cuprins între11.7°C şi 27.8°C (11°F şi 82°F).] (ro)
C&L Inventory
[Złożona pozostałość z destylacji strumieni różnych operacji rafineryjnych. Składa się z węglowodorów o liczbie atomów węgla w zakresie od C4 do C5, głównie butan i wrze w zakresie ok. od -11,7°C do 27,8°C (11°F do 82°F).] (pl)
C&L Inventory
[Πολύπλοκο υπόλειμμα της απόσταξης ρευμάτων από διάφορες διεργασίες διυλιστηρίου. Συνίσταται από υδρογονάνθρακες με αριθμό ατόμων άνθρακα από C4 έως C5, κυρίως βουτάνιο, που αποστάζουν μεταξύ -11,7°C και 27,8°C περίπου.] (el)
C&L Inventory
[Комплексен остатък, получен при дестилация на потоци от различни операции в рафинерията. Състои се от въглеводороди с брой на въглеродните атоми в интервала от С4 до С5 включително, преобладаващо бутан, и с температура на кипене приблизително в интервала от -11,7 °C до 27,8 °C. (11°F до 82°F).] (bg)
C&L Inventory
Atlikumi (nafta), alkilēšanas sadalītājs, bagāti ar C4 (lv)
C&L Inventory
Een complex residu, afkomstig uit de destillatie van stromen uit uiteenlopende raffinagebewerkingen. Bestaat uit koolwaterstoffen, C4 tot en met C5, overwegend butaan, met een kooktraject van ongeveer -11,7°C tot 27,8°C. (nl)
C&L Inventory
En sammensat remanens fra destillationen af strømme fra forskellige raffinaderiprocesser. Den består af carbonhydrider C4 til og med C5, overvejende butan, med kogeinterval omtrent fra -11,7°C til 27,8°C (11 ºF til 82 ºF). (da)
C&L Inventory
gas di petrolio (it)
C&L Inventory
Gase aus der Erdölverarbeitung (de)
C&L Inventory
Gaser (petroleum), alkyleringsseparationstorns, C4-rika (sv)
C&L Inventory
gases de petróleo (es)
C&L Inventory
gaz de pétrole (fr)
C&L Inventory
Gaz petrolier (mt)
C&L Inventory
Gaz petrolier (ro)
C&L Inventory
Gaz z ropy naftowej (pl)
C&L Inventory
Gás de petróleo (pt)
C&L Inventory
Jäägid (nafta), alküülimiskolonnist, C4-rikkad (et)
C&L Inventory
Jäännökset (maaöljy), alkylointijakotislauskolonni, C4-rikas (fi)
C&L Inventory
Komplexa återstoder från destillation av strömmar från olika raffinaderiprocesser. Består av kolväten C4 till C5, främst butan, med ungefärligt kokpunktsintervall från -11,7 °C till 27,8 °C. (sv)
C&L Inventory
Kulbrintegasser (da)
C&L Inventory
Kőolaj gáz (hu)
C&L Inventory
Likučiai (nafta), alkilinimo dujų atskyrimo kolona, turi daug C4 (lt)
C&L Inventory
Maaöljykaasu (fi)
C&L Inventory
Maradékok (nyersolaj), alkilező hasító, C4-ben gazdag (hu)
C&L Inventory
Monimutkainen jäännös useiden jalostusoperaatioiden virtojen tislauksesta. Koostuu hiilivedyistä, joiden hiililuvut ovat välillä C4:stä C5:een, pääasiassa butaanista ja jotka kiehuvat likimäärin välillä -11,7 °C:sta 27,8°C:een (11°F-82°F). (fi)
C&L Inventory
Naftagaas (et)
C&L Inventory
Naftas gāze (lv)
C&L Inventory
Naftni plin (hr)
C&L Inventory
Naftos dujos (lt)
C&L Inventory
Ostaci (nafta), spliter alkilacije, s pretežito C4 (hr)
C&L Inventory
ostanki (zemeljsko olje), separator alkiliranja, bogat na C4 (sl)
C&L Inventory
Petroleumgas (nl)
C&L Inventory
Petroleumgas (sv)
C&L Inventory
petroleumsgass (no)
C&L Inventory
plin iz predelave zemeljskega olja (sl)
C&L Inventory
plyn zo spracovania ropy (sk)
C&L Inventory
Pozostałości (ropa naftowa) z rozdzielenia gazów po alkilacji, bogate w węglowodory C4 (pl)
C&L Inventory
Residuen (aardolie), alkyleringssplitter, C4-rijk (nl)
C&L Inventory
residui (petrolio), splitter di alchilazione, ricchi di C4 (it)
C&L Inventory
residuo complejo de la destilación de corrientes de diversas operaciones de refinería; compuesta de hidrocarburos con un número de carbonos dentro del intervalo de C4 a C5, en su mayor parte butano y con un intervalo de ebullición aproximado de -11,7 °C a 27,8 °C (es)
C&L Inventory
Residuo complesso della distillazione di correnti provenienti da varie operazioni di raffineria. È costituita da idrocarburi con numero di atomi di carbonio nell'intervallo C4-C5, prevalentemente butano, e punto di ebollizione nell'intervallo -11,7°C - 27,8°C ca. (da 11°F a 82°F). (it)
C&L Inventory
residuos (petróleo), separador de alquilación ricos en C4 (es)
C&L Inventory
rester (petroleum), alkyleringssplitter, C4-rike (no)
C&L Inventory
rester (råolie), alkyleringssplitter-, C4-rige (da)
C&L Inventory
Resíduo complexo da destilação de correntes provenientes de várias operações de refinaria. É constituído por hidrocarbonetos com número de átomos de carbono na gama C4 a C5, com predominância de butano, e destilação no intervalo aproximado de 11,7 °C a 27,8 °C. (pt)
C&L Inventory
Resíduos (petróleo), de separador (splitter) da alquilação, ricos em C4 (pt)
C&L Inventory
Reziduuri (petrol), separator de alchilare, bogate în C4 (mt)
C&L Inventory
Reziduuri (petrol), separator de alchilare, bogate în C4 (ro)
C&L Inventory
Ropný plyn (cs)
C&L Inventory
Résidu complexe issu de la distillation de mélanges provenant de diverses opérations de raffinerie. Se compose d'hydrocarbures dont le nombre de carbones se situe principalement dans la gamme C4-C5, principalement du butane, et dont le point d'ébullition est compris entre -11,7 °C et 27,8 °C. (fr)
C&L Inventory
Résidus (pétrole), colonne de séparation de produits d'alkylation, riches en C4;gaz de pétrole;[résidu complexe issu de la distillation de produits résultant de diverses opérations de raffinage. Se compose d'hydrocarbures comportant 4 à 5 atomes de carbone (C4-C5), essentiellement du butane, et dont l'intervalle d'ébullition est compris approximativement entre - 11,7 et 27,8 oC (entre 11 et 82o F).] (fr)
C&L Inventory
Rückstände (Erdöl), Trennung durch Alkylierung, C4-reich (de)
C&L Inventory
Un reziduu complex rezultat prin distilarea produşilor diferitelor procese de rafinare. Constă în hidrocarburi al căror număr de atomi de carbon variază între C4 şi C5 , predominând butanul şi având punctul de fierbere cuprins între11.7°C şi 27.8°C (11°F şi 82°F). (mt)
C&L Inventory
Zbytky (ropné), alkylační separátor, bohaté na C4; (cs)
C&L Inventory
zvyšky (ropné), z destilácie, s vysokým obsahom C4 (sk)
C&L Inventory
Πετρελαϊκό αέριο (el)
C&L Inventory
υπολείμματαΥπολείμματα (πετρελαίου), διαχωριστήρα αλκυλίωσης, πλούσια σε C4 (el)
C&L Inventory
Нефтен газ (bg)
C&L Inventory
Остатъчни продукти (нефт), от разделителна колона в инсталация за алкилиране, богати на С4 (bg)
C&L Inventory
Residues (petroleum), alkylation splitter, C4-rich
Other
Residues (petroleum), alkylation splitter, C4-rich
Registration dossier
649-087-00-2
Index number
C&L Inventory
68513-66-6
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, Aerosols Directive - Flammable Contents - Labelling Requirements, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Pressure Equipment Directive - Group 1 Fluids Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 19 studies submitted
  • 8 studies processed
C Physical state at 20°C and 1013 hPa
Gaseous (100%) [8]
C Form
Liquified gas (100%) [7]
C Odour
Other (67%), Odourless (17%), Slight (17%) [6]
C Substance type
Petroleum product (100%) [6]

Type of Study provided
Studies with data
Key study 8
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Physical state at 20°C and 1013 hPa
Gaseous (50%), Liquid (50%)
Form
Gas under pressure: liquefied gas (100%)
Colour
colourless (100%)

Melting/freezing point

Study results
  • 14 studies submitted
  • 11 studies processed
R Melting / freezing point
-187.6 - -105.52 °C @ 101.3 kPa [11]

Type of Study provided
Studies with data
Key study 11
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
-153.5 - 5.49 °C

Boiling point

Study results
  • 14 studies submitted
  • 10 studies processed
R Boiling point
-161.48 - 3.71 °C @ 101.3 - 101.325 kPa [10]

Type of Study provided
Studies with data
Key study 10
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
-29.6 - 80.09 °C

Density

Study results
  • 17 studies submitted
  • 11 studies processed
R Density
0.001 - 0.589 g/cm³ @ -162 - 25 °C [6]
R Relative density
0.56 - 0.98 @ 20 - 25 °C [6]

Type of Study provided
Studies with data
Key study 11
Supporting study 5
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.598 - 0.876

Vapour pressure

Study results
  • 11 studies submitted
  • 10 studies processed
R Vapour pressure
100 - 50 400 000 000 000 000 kPa @ -161.7 - 26.85 °C [31]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
99.5 - 8 720 hPa @ 20 - 22 °C

Partition coefficient

Study results
  • 13 studies submitted
  • 13 studies processed
R Log Pow
1.09 - 3.39 @ 20 °C and pH 7 [13]

Type of Study provided
Studies with data
Key study 12 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2.13 - 2.17 @ 20 °C

Water solubility

Study results
  • 23 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
131 - 735 mg/L @ 20 - 25 °C and pH 7 [6]

Type of Study provided
Studies with data
Key study 11
Supporting study 12
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
186.5 - 1 880 mg/L @ 23.5 - 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 2
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 4 studies submitted
  • 3 studies processed
R Flash point
-104 - -60 °C @ 101.3 kPa [3]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
-84 °C

Auto flammability

Study results
  • 15 studies submitted
  • 12 studies processed
R Autoflammability / self-ignition
287 - 537 °C @ 99.8 - 102.1 kPa [12]

Type of Study provided
Studies with data
Key study 12
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
426 °C

Flammability

Study results
  • 15 studies submitted
  • 9 studies processed
C Interpretation of results
Extremely flammable (100%) [9]

Type of Study provided
Studies with data
Key study 11
Supporting study 3
Weight of evidence
Other 1
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 8 studies submitted
  • 8 studies processed
R Dissipation half life (DT50)
5.76 - 45 768 h [8]

Type of Study provided
Studies with data
Key study 3 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
12.5 days

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 22 studies submitted
  • 2 studies processed
C Interpretation of results
Readily biodegradable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence 3 15
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 15 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 15
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 16 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 15
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 80 µg/L (1)
Intermittent releases (freshwater) 53 µg/L (1)
Marine water 8 µg/L (1)
Intermittent releases (marine water) 5.3 µg/L (1)
Sewage treatment plant (STP) 39 mg/L (1)
Sediment (freshwater) 1.36 mg/kg sediment dw (1)
Sediment (marine water) 136 µg/kg sediment dw (1)
Hazard for Air
Air Hazard related to composition of atmosphere identified (2)
Hazard for Terrestrial Organism
Soil 225 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
LC50 (4 days) 5.3 - 627.644 mg/L [15]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 15 studies submitted
  • 1 study processed
P/RResults
NOEC (32 days) 800 µg/L [2]
LOEC (32 days) 1.6 mg/L [2]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
EC50 (48 h) 10 mg/L [1]
EC50 (24 h) 10 mg/L [1]
LC50 (48 h) 6.971 - 307.472 mg/L [14]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 15 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 15 studies submitted
  • 15 studies processed
P/RResults
EC50 (4 days) 7.039 - 124.406 mg/L [14]
EC50 (72 h) 32 - 100 mg/L [2]
EC10 (72 h) 10 - 34 mg/L [2]

Type of Study provided
Studies with data
Key study 1 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 2.21 mg/m³ carcinogenicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: High hazard (no threshold derived)
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 140 µg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DMEL) 464 ng/kg bw/day carcinogenicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
EYE Exposure
Hazard unknown (no further information necessary as no exposure expected)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 8
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 0.1 %
Inhalation: 100 %

Acute toxicity

Study results
oral
  • 3 studies submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
Not classified [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
inhalation
  • 21 studies submitted
  • 7 studies processed
P/RResults
LC50 (4 h) 43.767 - 65.4 mg/L air (rat) [2]
LC50 (4 h) 13 700 - 57 000 ppm (rat) [2]
LC50 (15 min) 1 442.738 - 1 443 mg/L air (rat) [2]
LC50 (15 min) 800 000 ppm (rat) [1]
LC50 (2 h) 1 237 mg/L air (mouse) [1]
M/CInterpretations of results
Not classified [7]

inhalation
Studies with data
Key study 7
Supporting study 7
Weight of evidence 4
Other 3
Data waiving
no waivers
dermal
  • 2 studies submitted
  • 1 study processed
M/CInterpretations of results
Not classified [1]

dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 22 948 mg/m³
Dermal route:
No adverse effect observed LD50 8 260 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 100 - 148.6 mg/kg bw/day [2]
LOAEL (rat): 25 - 200 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 30 studies submitted
  • 17 studies processed
P/RResults
NOAEC (rat): 96 - 21 394 mg/m³ air [5]
NOAEC (rat): 30 - 16 000 ppm [9]
NOAEC (mouse): 32 - 96 mg/m³ air [2]
NOAEC (mouse): 10 - 10 000 ppm [4]
LOAEC (rat): 21.641 mg/L air [1]

Study data: inhalation
Studies with data
Key study 24
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 7 214 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed LOAEC 8 600 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 30 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 29
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 15
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 22 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 11
Supporting study 11
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 3 445 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 11
Supporting study 2
Weight of evidence 2
Other 1
Data waiving
no waivers
Study data: developmental
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 17
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on fertility
Inhalation route:
Adverse effect observed NOAEC 5 700 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Inhalation route:
No adverse effect observed NOAEC 5 737 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 5
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Inhalation route:
No adverse effect observed NOAEC 10 257 mg/m³ (subchronic, rat)

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Categories Display