Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
265-047-3
CAS no.:
64741-47-5
Index number:
649-346-00-X
Molecular formula:
C32H62
SMILES:
CCC(C)C.CCCCCC.C1CCCCC1.CC1CCCCC1.CC1=CC(C)=CC=C1
InChI:
InChI=1S/C8H10.C7H14.C6H12.C6H14.C5H12/c1-7-4-3-5-8(2)6-7;1-7-5-3-2-4-6-7;1-2-4-6-5-3-1;1-3-5-6-4-2;1-4-5(2)3/h3-6H,1-2H3;7H,2-6H2,1H3;1-6H2;3-6H2,1-2H3;5H,4H2,1-3H3
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
10
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may be fatal if swallowed and enters airways, may cause genetic defects and may cause cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life with long lasting effects, is toxic if inhaled, is toxic in contact with skin, is toxic if swallowed, is very toxic to aquatic life, is suspected of damaging fertility or the unborn child, causes serious eye irritation, is an extremely flammable liquid and vapour, may cause drowsiness or dizziness, may cause respiratory irritation, may cause an allergic skin reaction and causes skin irritation.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 489 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Aquatic Chronic 2 H411
STOT SE 3 H336
Skin Irrit. 2 H315
Carc. 1B H350 Harmonised Classification
Muta. 1B H340 Harmonised Classification
Repr. 2 H361
Flam. Liq. 1 H224
Flam. Liq. 2 H225
Flam. Liq. 3 H226
Eye Irrit. 2 H319
STOT RE 2 H373
STOT SE 3 H335
STOT RE 1 H372
Acute Tox. 4 H332
https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (10% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (10% of REACH registrations).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (15% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels, air care products, anti-freeze products, coating products, lubricants and greases, washing & cleaning products and welding & soldering products.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), indoor use as processing aid and outdoor use as processing aid.

This substance is used in the following activities or processes at workplace: production of mixtures or articles by tabletting, compression, extrusion or pelletisation and the low energy manipulation of substances bound in materials or articles.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, manufacturing of the substance, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: fuels.

This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and closed batch processing in synthesis or formulation.

Other release to the environment of this substance is likely to occur from: indoor use as processing aid, outdoor use as processing aid, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: fuels.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

This substance is used in the following products: fuels.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals and rubber products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, of substances in closed systems with minimal release and as processing aid.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, as processing aid, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; ground and bond container and receiving equipment; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; keep container tightly closed; do not eat, drink or smoke when using this product; use explosion-proof equipment (electrical/ventilating/lighting/etc.); avoid release to the environment; use non-sparking tools; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. Take off contaminated clothing and wash it before reuse. If skin irritation or a rash occurs: get medical advice/attention. If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. Get medical advice/attention if you feel unwell. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. In case of fire: Use (measures specified by manufacturer/supplier) for extinction. Collect spillage. If inhaled: call a poison center or doctor/physician if you feel unwell. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention. Rinse the mouth. Do not induce vomiting. If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water. Follow specific treatment (see label).

Storage statements

Store this substance in a dry place; in a well-ventilated place and Keeping it cool; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Gazprom Marketing & Trading France 29, 68 Avenue des Champs Elysees 75008 Paris France
  • GAZPROM MARKETING AND TRADING FRANCE 24, 68 avenue des Champs Elysées 75008 PARIS France
  • Gazprom Marketing & Trading France 26, 68 Avenue des Champs Elysées 75008 PARIS France
  • Total Petrochemicals & Refining SA, Rue de l'Industrie,52 1040 Bruxelles Belgium
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France
  • Versalis France S.A.S., Route des Dunes 59279 Mardyck France
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy

Substance names and other identifiers

[A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.]
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
C&L Inventory
Low boiling point naphtha - unspecified
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
C&L Inventory
Natural gas condensates (petroleum)
EC Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Natural gas condensates (petroleum)
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Natural gas condensates (petroleum); Low boiling point naphtha -unspecified [ complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.]
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Natural gas condensates (petroleum); Low boiling point naphtha -unspecified
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
FCM Active and Intelligent Materials - CMRs not allowed for use, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
Natural gas condensates, petroleum
A complex combination of hydrocarbons separated as a liquid from natural gas in a surface separator by retrograde condensation. It consists mainly of hydrocarbons having carbon numbers predominantly in the range of C2 to C20. It is a liquid at atmospheric temperature and pressure.
Other
(Keerulise koostisega süsivesinike segu, mis eraldatakse vedelikuna maagaasist pindseparaatoris tagurpidi kondensatsioonil. Koosneb peamiselt süsivesinikest, mille süsiniku aatomite arv on valdavalt vahemikus C2 kuni C20. Normaaltemperatuuril ja -rõhul on vedelas olekus.) (et)
C&L Inventory
(Složeni sastav ugljikovodika izdvojen kao tekućina iz prirodnog plina retrogradnom kondenzacijom u površinskom separatoru. Sastoji se uglavnom od ugljikovodika koji imaju broj ugljikovih atoma pretežito u području od C2 do C20. Na atmosferskoj temperaturi i pri atmosferskom tlaku je u tekućem stanju.) (hr)
C&L Inventory
[Kompleks blanding av hydrokarboner separert som en væske fra naturgass i en overflateseparator ved retrograd kondensering. Består for det meste av hydrokarboner, hovedsakelig C2 til C20. Flytende ved atmosfærisk temperatur og trykk.] (no)
C&L Inventory
[Kompleksna kombinacija ogljikovodikov ločena kot tekočina iz zemeljskega plina na površinskem separatorju z retrogradno kondenzacijo. Sestoji pretežno iz ogljikovodikov s številom ogljikovih atomov pretežno v območju med C2 in C20. Pri temperaturi in tlaku atmosfere je tekočina.] (sl)
C&L Inventory
[komplexe Kombination von Kohlenwasserstoffen, abgetrennt von Erdgas als Flüssigkeit in einem Oberflächenabscheider durch retrograde Kondensation; besteht hauptsächlich aus Kohlenwasserstoffen mit Kohlenstoffzahlen überwiegend im Bereich von C2 bis C20; flüssig unter Normalbedingungen] (de)
C&L Inventory
[Komplexná zmes uhľovodíkov oddelená v podobe kvapaliny zo zemného plynu v separátore spätnou kondenzáciou. Pozostáva najmä z uhľovodíkov s počtom atómov uhlíka prevažne v rozmedzí od C2 do C20. Pri bežnej teplote a atmosférickom tlaku je to kvapalina.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi sub formă de lichid separat din gazul natural prin condensare retrogradă în separator de fază. Constă cu precădere în hidrocarburi al căror număr de atomi de carbon variază între C2 şi C20. Este lichidă la temperatură şi presiune atmosferică.] (ro)
C&L Inventory
[Ogļūdeņražu savienojumu komplekss, kas atdalīts kā šķidrums no dabasgāzes, pielietojot atgriezenisko kondensāciju virsmas separatorā . Sastāv pārsvarā no ogļūdeņražiem ar oglekļa atomu skaitu pārsvarā no C2 līdz C20. Atmosfēras temperatūrā un spiedienā tas ir šķidrums.] (lv)
C&L Inventory
[Složitá směs uhlovodíků oddělených jako kapalina ze zemního plynu zpětnou kondenzací v povrchovém separátoru. Je složena převážně z uhlovodíků s počtem uhlíkových atomů převážně v rozmezí C2 až C20. Za atmosférické teploty a tlaku je to kapalina.] (cs)
C&L Inventory
[Sudėtinis angliavandenilių mišinys, atskirtas kaip skystis nuo gamtinių dujų paviršiniame separatoriuje priešpriešinio kondensavimo būdu. Jį sudaro daugiausia angliavandeniliai, turintys anglies atomų skaičių daugiausia nuo C2 iki C20. Jis yra skystis atmosferos temperatūros ir slėgio sąlygomis.] (lt)
C&L Inventory
[Szénhidrogének komplex elegye, melyet folyadékként választanak el a földgáztól felületi szeparátorban végzett retrográd kondenzációval. Főleg olyan szénhidrogénekből áll, melyek szénatomszáma főleg a C2-C20 tartományban van. Atmoszférikus nyomáson és hőmérsékleten folyadék.] (hu)
C&L Inventory
[Πολύπλοκος συνδυασμός υδρογονανθράκων που διαχωρίζεται ως υγρό από φυσικό αέριο σε διαχωριστήρα επιφάνειας με οπισθοδρομική συμπύκνωση. Συνίσταται κυρίως από υδρογονάνθρακες με αριθμό ατόμων άνθρακα κυρίως μεταξύ C2 και C20. Σε ατμοσφαιρική θερμοκρασία και πίεση είναι υγρό.] (el)
C&L Inventory
[Комплексна комбинация от въглеводороди, сепарирана като течност от природен газ в повърхностен сепаратор чрез противоточна кондензация. Състои се основно от въглеводороди с брой на въглеродните атоми преобладаващо в интервала от C2 до C20 включително. Представлява течност при атмосферна температура и налягане.] (bg)
C&L Inventory
Aardgascondensaten (aardolie) (nl)
C&L Inventory
Alacsony forráspontú benzin – nem meghatározott (hu)
C&L Inventory
combinación compleja de hidrocarburos separada como líquido del gas natural en un separador de superficie por condensación retrógrada; compuesta principalmente de hidrocarburos con un número de carbonos en su mayor parte dentro del intervalo de C2 a C20; es líquida a temperatura y presión atmosféricas (es)
C&L Inventory
Combination complexe d'hydrocarbures séparée sous forme liquide du gaz naturel dans un séparateur de surface par condensation rétrograde. Se compose principalement d'hydrocarbures dont le nombre de carbones se situe en majorité dans la gamme C2-C20. Liquide à température et pression atmosphériques. (fr)
C&L Inventory
Combinazione complessa di idrocarburi separata, allo stato liquido, dal gas naturale in un separatore superficiale mediante condensazione retrograda. È costituita principalmente da idrocarburi con numero di atomi di carbonio prevalentemente nell'intervallo C2-20. A temperatura e pressione atmosferiche è allo stato liquido. (it)
C&L Inventory
Combinação complexa de hidrocarbonetos separada, no estado líquido, do gás natural por condensação retrógrada num separador de superfície. É constituída sobretudo por hidrocarbonetos com número de átomos de carbono predominantemente na gama C2 a C20. É um líquido à temperatura e pressão atmosféricas. (pt)
C&L Inventory
condensados de gas natural (petróleo) (es)
C&L Inventory
Condensados de gás natural (petróleo) (pt)
C&L Inventory
Condensats de gaz naturel (pétrole);naphta à bas point d'ébullition — non spécifié;[combinaison complexe d'hydrocarbures séparée sous forme liquide du gaz naturel dans un séparateur de surface par condensation rétrograde. Se compose principalement d'hydrocarbures comportant majoritairement entre 2 et 20 atomes de carbone (C2-C20).] Liquide à température et pression atmosphériques.] (fr)
C&L Inventory
Dabas gāzes kondensāti (nafta) (lv)
C&L Inventory
Een complexe verzameling koolwaterstoffen, in een oppervlakteseparator door middel van retrograde condensatie als vloeistof afgescheiden van aardgas. Bestaat voornamelijk uit koolwaterstoffen, overwegend C2 tot C20. Vloeibaar bij atmosferische temperatuur en druk. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider adskilt som en væske fra naturgas i en overfladeseparator ved retrograd kondensation. Den består hovedsagelig af carbonhydrider, overvejende C2 til C20. Den er en væske ved atmosfærisk temperatur og tryk. (da)
C&L Inventory
Erdgaskondensate (Erdöl) (de)
C&L Inventory
Fracţia nafta cu punct de fierbere la temperaturi scăzute- nespecificat (mt)
C&L Inventory
Fracţia nafta cu punct de fierbere la temperaturi scăzute- nespecificat (ro)
C&L Inventory
Földgáz kondenzátumok (nyersolaj) (hu)
C&L Inventory
Gamtinių dujų kondensatai (nafta) (lt)
C&L Inventory
gas naturale, condensati (petrolio) (it)
C&L Inventory
Komplex blandning av kolväten, separerad som vätska från naturgas i en ytseparator genom retrograd kondensering. Består främst av kolväten, från C2 till C20. Vätska vid normala tryck- och temperaturbetingelser. (sv)
C&L Inventory
Kondensaty gazu ziemnego (ropa naftowa) (pl)
C&L Inventory
Kondenzati prirodnog plina (nafta) (hr)
C&L Inventory
kondenzati zemeljskega plina (zemeljsko olje) (sl)
C&L Inventory
kondenzáty zemného plynu (ropné) (sk)
C&L Inventory
Kondenzáty zemního plynu (ropné) (cs)
C&L Inventory
Lavtkogende uspecificeret nafta (da)
C&L Inventory
lavtkokende nafta - uspesifisert (no)
C&L Inventory
Ligroīns ar zemu viršanas temperatūru – nestandarta (lv)
C&L Inventory
Luonnonkaasukondensaatit (maaöljy) (fi)
C&L Inventory
Lågkokande nafta – ospecificerad (sv)
C&L Inventory
Maagaasi kondensaadid (nafta) (et)
C&L Inventory
Madala keemispunktiga raskbensiin – määratlemata (et)
C&L Inventory
Matalalla kiehuva teollisuusbensiini – täsmentämätön (fi)
C&L Inventory
Monimutkainen seos hiilivetyjä, erotettu nesteenä luonnonkaasusta pintaseparaattorissa paluujaekondensaatiolla. Koostuu pääasiassa hiilivedyistä, joiden hiililuvut ovat pääasiassa välillä C2:sta C20:een. Nestemäinen atmosfäärisessä lämpötilassa ja ilmanpaineessa. (fi)
C&L Inventory
nafta con basso punto di ebollizione - non specificata (it)
C&L Inventory
Nafta de baixo ponto de ebulição - não especificada (pt)
C&L Inventory
nafta de bajo punto de ebullición, sin especificar (es)
C&L Inventory
Nafta met laag kookpunt - niet gespecifieerd (nl)
C&L Inventory
nafta z nizkim vreliščem – neopredeljeno (sl)
C&L Inventory
naphta à point d'ébullition bas - non spécifié (fr)
C&L Inventory
Naphtha, niedrigsiedend, nicht spezifiziert (de)
C&L Inventory
Naturgaskondensat (petroleum) (sv)
C&L Inventory
naturgaskondensater (råolie) (da)
C&L Inventory
naturgasskondensater (petroleum) (no)
C&L Inventory
Nisko-vrijući benzin - nespecificiran (hr)
C&L Inventory
Niskowrząca benzyna - niespecyfikowana (pl)
C&L Inventory
Nízkovroucí benzínová frakce – nespecifikovaná (cs)
C&L Inventory
O combinaţie complexă de hidrocarburi sub formă de lichid separat din gazul natural prin condensare retrogradă în separator de fază. Constă cu precădere în hidrocarburi al căror număr de atomi de carbon variază între C2 şi C20. Este lichidă la temperatură şi presiune atmosferică. (mt)
C&L Inventory
Produşi de condensare ai gazului natural (petrol) (mt)
C&L Inventory
Produşi de condensare ai gazului natural (petrol) (ro)
C&L Inventory
Złożona mieszanina węglowodorów wydzielona jako ciecz z gazu ziemnego w powierzchniowym separatorze przez wsteczną kondensację. Składa się przede wszystkim z węglowodorów o liczbie atomów węgla głównie w zakresie od C2 do C20. Pod ciśnieniem atmosferycznym i w temp. otoczenia jest cieczą. (pl)
C&L Inventory
ťažký benzín s nízkou teplotou varu - nešpecifikovaný (sk)
C&L Inventory
Žematemperatūris pirminis benzinas – neapibrėžtas (lt)
C&L Inventory
Νάφθα χαμηλού σημείου ζέσεως - μη προσδιοριζόμενη (el)
C&L Inventory
συμπυκνώματα φυσικού αερίου (πετρελαίου) (el)
C&L Inventory
Кондензати на природен газ (нефт) (bg)
C&L Inventory
Нискооктанов бензин с ниска температура на кипене-неспецифициран (bg)
C&L Inventory
Natural gas condensates (petroleum)
Other
1,3-xylene; 2-methylbutane; cyclohexane; hexane; methylcyclohexane
Other
Condensate
C&L Inventory
Condensato Pesante, Condensato leggero
Registration dossier
Erdgaskondensate Rohöl
C&L Inventory
Natural gas condensates
C&L Inventory
Natural gas condensates (petroleum)
C&L Inventory, Registration dossier
Natural gas condensates (petroleum)
Registration dossier
Reaction mass of Natural gas condensates and 74-98-6
C&L Inventory
Stable natural gas condensate
Registration dossier
Condensats
Registration dossier
Naphtha clarifié ordinaire/NCO
Registration dossier
64741-47-5
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work
649-346-00-X
Index number
C&L Inventory

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 26 studies submitted
  • 26 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [26]
C Form
Liquid (52%), Other (43%) [21]
C Odour
Characteristic of aromatic compounds (76%), Other (19%) [21]
C Substance type
Petroleum product (65%), Organic (35%) [23]

Type of Study provided
Studies with data
Key study 7 19
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)
Form
Liquid (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 6 studies processed
R Melting / freezing point
-100 - -29 °C @ 101.3 kPa [8]

Type of Study provided
Studies with data
Key study 6
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
5.49 - 32.2 °C

Boiling point

Study results
  • 35 studies submitted
  • 25 studies processed
R Boiling point
-20 - 280 °C @ 100.7 - 101.33 kPa [27]

Type of Study provided
Studies with data
Key study 21 5
Supporting study 3 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
80.09 - 172.2 °C

Density

Study results
  • 25 studies submitted
  • 7 studies processed
R Relative density
0.62 - 0.89 @ 15 - 20 °C [7]

Type of Study provided
Studies with data
Key study 18
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Relative density at 20°C
0.876 - 0.98

Vapour pressure

Study results
  • 31 studies submitted
  • 23 studies processed
R Vapour pressure
4 - 2 400 hPa @ 20 - 50 °C [31]

Type of Study provided
Studies with data
Key study 23
Supporting study 3 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Vapour pressure
1.86 - 99.5 hPa @ 20 °C

Partition coefficient

Study results
  • 12 studies submitted
  • 9 studies processed
R Log Pow
1.53 - 7.22 @ 23 - 25 °C and pH 6.2 - 7 [9]

Type of Study provided
Studies with data
Key study 8 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
2.13 - 2.78 @ 20 °C

Water solubility

Study results
  • 8 studies submitted
  • 6 studies processed
R Water solubility (mass/vol.)
25 - 600 mg/L @ 20 °C and pH 5.2 - 9.1 [5]
R Water solubility (vol%)
0.1 - 0.7 vol% @ 20 °C and pH 6.4 [2]

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 5 summaries submitted
  • 2 summaries processed
Water solubility
20 - 1 880 mg/L @ 23.5 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 6
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 9 studies submitted
  • 9 studies processed
R Flash point
-40 - 43 °C @ 101.3 kPa [11]

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 14 studies submitted
  • 10 studies processed
R Autoflammability / self-ignition
280 - 502 °C @ 101.3 - 101.325 kPa [10]

Type of Study provided
Studies with data
Key study 8 2
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 3 studies submitted
  • 2 studies processed
C Interpretation of results
Extremely flammable (100%) [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Extremely flammable (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 21 studies submitted
  • 18 studies processed
R dynamic viscosity (in mPa s)
0.45 - 0.95 [10]
R kinematic viscosity (in mm²/s)
0.473 - 1.5 [25]

Type of Study provided
Studies with data
Key study 16 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 17 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 12
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 5 summaries submitted
  • 3 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (67%), Readily biodegradable (33%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
1 678 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Adsorption/desorption

Study results
  • 5 studies submitted
  • 1 study processed
R log Koc
1.327 - 6.509 dimensionless [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Study results
  • 1 study submitted
  • 1 study processed
% Distribution in Media:
R Air 93.02 % [1]
R Water 5.83 % [1]
R Soil 0.34 % [1]
R Sediment 0.81 % [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (2)
Intermittent releases (freshwater) No data available: testing technically not feasible (2)
Marine water No data available: testing technically not feasible (2)
Intermittent releases (marine water) No data available: testing technically not feasible (2)
Sewage treatment plant (STP) No data available: testing technically not feasible (2)
Sediment (freshwater) No data available: testing technically not feasible (2)
Sediment (marine water) No data available: testing technically not feasible (2)
Hazard for Air
Air Hazard related to composition of atmosphere identified (1)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 43 studies submitted
  • 14 studies processed
P/RResults
LC50 (4 days) 1 mg/L [1]
LL50 (4 days) 1.1 - 10 mg/L [5]
EL50 (4 days) 5.54 - 28.3 mg/L [9]

Type of Study provided
Studies with data
Key study 5 9
Supporting study 29
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 14 studies submitted
  • 11 studies processed
P/RResults
EL10 (14 days) 1.05 - 5.42 mg/L [9]
EL50 (21 days) 10 mg/L [2]
NOELR (21 days) 2.6 mg/L [2]

Type of Study provided
Studies with data
Key study 9 2
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 35 studies submitted
  • 13 studies processed
P/RResults
EC50 (48 h) 1.2 - 2.7 mg/L [2]
EL50 (48 h) 1.2 - 26.68 mg/L [13]
NOELR (48 h) 500 µg/L [2]

Type of Study provided
Studies with data
Key study 4 9
Supporting study 22
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 16 studies submitted
  • 11 studies processed
P/RResults
NOELR (21 days) 2.6 - 16 mg/L [4]
EL10 (21 days) 990 - 5 110 µg/L [9]
EL50 (21 days) 10 - 40 mg/L [4]

Type of Study provided
Studies with data
Key study 2 9
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 43 studies submitted
  • 13 studies processed
P/RResults
EC50 (4 days) 910 - 1 800 µg/L [4]
EC50 (72 h) 1.3 - 2 mg/L [2]
NOEC (4 days) 120 µg/L [1]
EL10 (72 h) 420 - 2 160 µg/L [9]
EL50 (4 days) 1.2 - 3.7 mg/L [6]

Type of Study provided
Studies with data
Key study 4 9
Supporting study 30
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 12 studies submitted
  • 2 studies processed
P/RResults
EC50 (40 h) 15.41 mg/L [2]

Type of Study provided
Studies with data
Key study 12
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 13 studies submitted
  • 9 studies processed
P/RResults
EC10 (28 days) 220 - 29 600 µg/kg sediment dw [9]
EC50 (28 days) 27.2 - 154.3 mg/kg sediment dw [9]

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 2
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 15 studies submitted
  • 9 studies processed
P/RResults
EC10 (56 days) 21.3 - 29 mg/kg soil dw [9]
EC50 (28 days) 111 - 151.5 mg/kg soil dw [9]

Type of Study provided
Studies with data
Key study 10
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 17 studies submitted
  • 9 studies processed
P/RResults
EC10 (28 days) 12 - 16.3 mg/kg soil dw [9]
EC50 (28 days) 62.4 - 85.2 mg/kg soil dw [9]

Type of Study provided
Studies with data
Key study 10
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 4
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 15 studies submitted
  • 9 studies processed
P/RResults
EC10 (21 days) 35.3 - 74.6 mg/kg soil dw [18]
EC50 (14 days) 184.3 - 389.4 mg/kg soil dw [18]

Type of Study provided
Studies with data
Key study 10
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 6 summaries submitted
  • 5 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 800 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 286.4 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 2.31 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 160.23 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 950 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 140 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 152 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 690 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 143.5 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: High hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 25.6 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5 1
Supporting study 6 2
Weight of evidence
Other 2
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Study data: dermal absorption
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 3 3
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 3 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 1 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 95 studies submitted
  • 10 studies processed
P/RResults
LD50 512 - 6 631 mg/kg bw (rat) [12]
LD50 5 251 - 5 627 mg/kg bw (mouse) [2]
M/CInterpretations of results
Practically nontoxic [1]

Type of Study provided
oral
Studies with data
Key study 9 1
Supporting study 45 40
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 88 studies submitted
  • 13 studies processed
P/RResults
LC50 (6 h) 1.723 mg/L air (rat) [1]
LC50 (6 h) 284 - 353 ppm (rat) [2]
LC50 (4 h) 5.14 - 43.767 mg/L air (rat) [6]
LC50 (4 h) 5 922 - 13 700 ppm (rat) [6]
LC50 (6 h) 738.5 mg/m³ air (mouse) [1]
M/CInterpretations of results
Toxic [2]

inhalation
Studies with data
Key study 11 2
Supporting study 36 39
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 96 studies submitted
  • 9 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 2 000 - 12 126 mg/kg bw (rabbit) [6]
LD50 5 000 mL/kg bw (rabbit) [1]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 7 1
Supporting study 44 43
Weight of evidence 1
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Oral route:
Adverse effect observed LD50 590 mg/kg bw
Inhalation route:
Adverse effect observed LC50 1 972 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 217 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3 6
Supporting study 116 90
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 98 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 4 2
Supporting study 44 43
Weight of evidence 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 92 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 5 1
Supporting study 42 41
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 22 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 4 - 625 mg/kg bw/day [9]
NOAEL (mouse): 625 mg/kg bw/day [1]
LOAEL (rat): 25 - 1 250 mg/kg bw/day [4]
LOAEL (mouse): 1 250 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 6 3
Supporting study 7 4
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 59 studies submitted
  • 15 studies processed
P/RResults
NOAEC (rat): 96 - 20 000 mg/m³ air [6]
NOAEC (rat): 30 - 7 000 ppm [12]
NOAEC (mouse): 32 - 96 mg/m³ air [2]
NOAEC (mouse): 5 - 2 000 ppm [5]
LOAEC (rat): 2.261 - 4.71 mg/L air [2]

Study data: inhalation
Studies with data
Key study 14 3
Supporting study 19 21
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 104 studies submitted
  • 8 studies processed
P/RResults
NOAEL (rat): 375 - 3 750 mg/kg bw/day [2]
NOEL (rabbit): 200 - 2 000 mg/kg bw/day [14]

Study data: dermal
Studies with data
Key study 9 1
Supporting study 43 49
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 4 mg/kg bw/day (subacute, rat)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 1 402 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 27.6 mg/m³ (subchronic, mouse)

Genetic toxicity

Study results
Study data: in vitro
  • 67 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 20 6
Supporting study 20 19
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: in vivo
  • 41 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 6 8
Supporting study 12 14
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
M/C Summaries
  • 5 summaries submitted
  • 3 summaries processed
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 36 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 8 7
Supporting study 12 9
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 3 summaries processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 9 869 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 8 2
Supporting study 3 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 33 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 12 5
Supporting study 7 6
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Effect on fertility
Inhalation route:
No adverse effect observed NOAEC 20 000 mg/m³ (chronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 60 mg/kg bw/day (subacute, rat)
Dermal route:
No adverse effect observed NOAEL 500 mg/kg bw/day (subchronic, rat)
Inhalation route:
No adverse effect observed NOAEC 23 900 mg/m³ (subchronic, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 4 5
Supporting study 2 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant