Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
243-900-0
CAS no.:
20592-85-2
Index number:
Molecular formula:
SMILES:
InChI:
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
22
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 194 C&L notifications submitted to ECHA

Not Classified
Eye Irrit. 2 H319
Skin Corr. 1B H314
Acute Tox. 4 H302
Met. Corr. 1 H290
Skin Irrit. 2 H315
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 13 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance has not been registered under the REACH Regulation, therefore as yet ECHA has not received any data about this substance from registration dossiers.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: water softeners, washing & cleaning products, air care products, polishes and waxes, cosmetics and personal care products, coating products and fertilisers.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, treatment of articles by dipping and pouring and roller or brushing applications.

Release to the environment of this substance can occur from industrial use: in the production of articles and in processing aids at industrial sites. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).

This substance can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: metal (e.g. cutlery, pots, toys, jewellery), wood (e.g. floors, furniture, toys) and stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).

This substance is used in the following products: water softeners, coating products, washing & cleaning products, air care products, polishes and waxes, cosmetics and personal care products and fertilisers.

This substance is used in the following areas: building & construction work and agriculture, forestry and fishing. This substance is used for the manufacture of: mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, non-industrial spraying, hand mixing with intimate contact only with personal protective equipment available, roller or brushing applications, mixing in open batch processes, closed, continuous processes with occasional controlled exposure and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: pH regulators and water treatment products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, transfer of substance into small containers, laboratory work and closed batch processing in synthesis or formulation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance and in processing aids at industrial sites.

This substance is used in the following products: water softeners, pH regulators and water treatment products, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: mining and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: textile, leather or fur, pulp, paper and paper products, metals, fabricated metal products, machinery and vehicles and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, closed batch processing in synthesis or formulation and industrial spraying.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles and as processing aid. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, transfer of substance into small containers, closed processes with no likelihood of exposure, batch processing in synthesis or formulation with opportunity for exposure, laboratory work and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures and in processing aids at industrial sites.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: keep only in original packaging; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Absorb spillage to prevent material damage. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. If eye irritation persists get medical advice/attention.

Storage statements

Store this substance in a corrosive resistant container with a resistant inner liner (or in other specified container type).

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • ACRILATOS S.A.U, Avda. Extremadura, s/n. Pol. Ind. El Colomer 12200 Onda Castellón Spain
  • Airedale Chemical Company Ltd, Skipton Road Cross Hills BD20 7BX Keighley West Yorkshire United Kingdom
  • APLICACIÓN Y SUMINISTROS TEXTILES, S.A., Av. Camí Reial 13-15 Pol. Ind. Riera de Caldes 08184 Palau-Solità i Plegamans Barcelona Spain
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED (Shandong Taihe Water Treatment Technologies Co., Ltd.), Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Covance Clinical Development SA 016, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Detergencia y Textil Quimica SL, Pol.Ind. La Bovila Nave 1 08232 Viladecavalls Barcelona Spain
  • Eurodye-ctc, Chaussée de Charleroi 119 B-1370 Jodoigne Belgium
  • Giovanni Bozzetto SpA, Via Provinciale, 12 24040 Filago Lombardia Italy
  • Italmatch Chemicals GB Ltd, Ashburton Road West M17 1SX Manchester United Kingdom
  • Italmatch UK Ltd., Corporation Road NP19 4XF Newport South Wales - Gwent United Kingdom
  • LEFRANT RUBCO, 64 rue de PARIS 80400 MUILLE VILLETTE France
  • Pulcra Chemicals GmbH, Isardamm 79-83 82538 Geretsried Germany
  • ZSCHIMMER & SCHWARZ MOHSDORF GmbH & Co KG, Chemnitztalstraße 1 09217 BURGSTÄDT Germany
  • Solvay Solutions UK Limited, 34 CLARENDON ROAD WD17 1JJ WATFORD Hertfordshire United Kingdom

Substance names and other identifiers

[[]nitrilotris(methylene)]trisphosphonic acid, sodium salt
Other
[nitrilotris(methylene)]trisphosphonic acid, sodium salt
EC Inventory, REACH pre-registration
Phosphonic acid, P,P',P''-[nitrilotris(methylene)]tris-, sodium salt (1:?)
Other
[bis(phosphonomethyl)amino]methylphosphonic acid
C&L Inventory
[bis(phosphonomethyl)amino]methylphosphonic acid, sodium salt
C&L Inventory
[nitrilotris(methylene)trisphosphonic acid, sodium alt
C&L Inventory
Amino Tri (Methylene Phosphonic Acid) Penta Sodium Salt
C&L Inventory
Amino tri (methylene phosphonic acid), sodium salt (ATMP xNa)
Registration dossier
Amino tris(methylene phosphonic acid), sodium salt (ATMP-xNa)
Registration dossier
Aminotri(methylene phosphonic acid), sodium salt
C&L Inventory
Aminotris(methylene phopshonic acid), Sodium salt; Na-ATMP
Registration dossier
ATMP-xNa
Registration dossier
ATMP-xNa, Amino tris(methylenephosphonic acid), xNa Salt
Registration dossier
nitrilotris(methylene)]trisphosphonic acid, sodium salt
C&L Inventory
pentasodium [{[(hydroxyphosphinato)methyl]imino}bis(methylene)]bis(phosphonate)
Registration dossier
sodium hydrogen {[bis(phosphonomethyl)amino]methyl}phosphonate
C&L Inventory, Registration dossier
Sodium salt of [nitrilotris(methylene)]trisphosphonic acid (3-5Na:1)
Registration dossier
Tetra sodium salt of Amino Trimethylene Phosphonic Acid
C&L Inventory
Airquest SAT
Registration dossier
Aminotris(methylenephosphonic acid), sodium salt
Registration dossier
ATMP.Na5
Registration dossier
ATMP.xNa
Registration dossier
Briquest 301-30SH
Registration dossier
Briquest 301-32S
Registration dossier
Cublen A 4014
Registration dossier
Cublen A 4015
Registration dossier
Flocon® 190
Registration dossier
nitrilotrimethylenetris (phosphonic acid), sodium salt
Registration dossier
Penta sodium salt of Amino Trimethylene Phosphonic Acid
Registration dossier
Phosphonic acid, [nitrilotris(methylene)]tris-, sodium salt
Registration dossier
POLIFLUX
Registration dossier
20592-85-2
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 7 studies submitted
  • 5 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (60%), Solid (40%) [5]
C Form
Not specified (80%), Liquid (20%) [5]
C Substance type
Organic (100%) [5]

Type of Study provided
Studies with data
Key study 1 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 4 studies submitted
  • 3 studies processed
R Melting / freezing point
177.85 °C [3]

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Boiling point

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 16 studies submitted
  • 2 studies processed
R Relative density
1.33 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 4 4
Weight of evidence 4 2
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Vapour pressure

Study results
  • 4 studies submitted
  • 3 studies processed
R Vapour pressure
0 - 0 Pa @ 25 °C [3]

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Vapour pressure
0 Pa @ 25 °C

Partition coefficient

Study results
  • 6 studies submitted
  • 3 studies processed
R Log Pow
-3.53 [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Log Kow (Log Pow)
-3.5

Water solubility

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 2
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4 2
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 8 studies submitted
  • 3 studies processed
C Interpretation of results
Non flammable (67%), GHS criteria not met (33%) [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 4
Exposure cons.
Other
C Summaries
  • 3 summaries submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 3 summaries submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 7 studies submitted
  • 3 studies processed
C Dissociating properties
Yes (100%) [3]
R Dissociation constant
2 - 12.3 @ 25 °C [18]

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 6 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 13 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study 9
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 3 summaries submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Half-life in freshwater
10 days @ 25 °C
Half-life in freshwater sediment
10 days @ 25 °C

Biodegradation in soil

Study results
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 6 1
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Half-life in soil
10 days @ 25 °C

Bioaccumulation: aquatic / sediment

Study results
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - L/kg ww
22 L/kg ww

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 10 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 3 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 460 µg/L (3)
Intermittent releases (freshwater) -
Marine water 46 µg/L (3)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 20 mg/L (3)
Sediment (freshwater) 150 - 690 mg/kg sediment dw (3)
Sediment (marine water) 15 - 69 mg/kg sediment dw (3)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 244 - 277 mg/kg soil dw (3)
Hazard for Predators
Secondary poisoning 170 - 333 mg/kg food (3)

Short–term toxicity to fish

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
LC50 (14 days) 150 mg/L [3]
LC50 (4 days) 160 - 1 000 mg/L [12]
NOEC (14 days) 47 mg/L [3]

Type of Study provided
Studies with data
Key study 4 1 2
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
LC50 for freshwater fish
160 mg/L

Long–term toxicity to fish

Study results
  • 4 studies submitted
  • 3 studies processed
P/RResults
NOEC (60 days) 23 mg/L [3]
LOEC (60 days) 47.6 mg/L [3]

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater fish
23 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 10 studies submitted
  • 6 studies processed
P/RResults
EC50 (48 h) 297 mg/L [3]
EC50 (24 h) 545 mg/L [3]
LC50 (48 h) 94 mg/L [3]
NOEC (48 h) 125 mg/L [3]

Type of Study provided
Studies with data
Key study 6 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 / LC50 for freshwater invertebrates
297 mg/L
EC50 / LC50 for marine invertebrates
94 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 3 studies processed
P/RResults
NOEC (28 days) 25 mg/L [3]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC10 / LC10 or NOEC for freshwater invertebrates
25 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible 3
Sci. unjustified
Exposure cons.
Other
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 13 studies submitted
  • 6 studies processed
P/RResults
NOEC (30 days) 200 mg/L [3]
LOEC (30 days) 500 mg/L [3]
EC0 (5 days) 100 mg/L [3]

Type of Study provided
Studies with data
Key study
Supporting study 4 2
Weight of evidence 2 1 4
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC10 or NOEC for microorganisms
200 mg/L

Sediment toxicity

Study results
  • 6 studies submitted
  • 2 studies processed
P/RResults
NOEC (10 days) 2 910 mg/kg sediment dw [2]
LC50 (10 days) 2 910 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 9.7 mg/m³ effect on fertility
Acute /short term: (DNEL) 9.7 mg/m³ effect on fertility
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.75 mg/kg bw/day effect on fertility
Acute /short term: (DNEL) 2.75 mg/kg bw/day effect on fertility
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (Low hazard (no threshold derived)) -
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.39 mg/m³ effect on fertility
Acute /short term: (DNEL) 2.39 mg/m³ effect on fertility
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.38 mg/kg bw/day effect on fertility
Acute /short term: (DNEL) 1.38 mg/kg bw/day effect on fertility
Local Effects
Long-term: (No hazard identified) -
Acute /short term: (Low hazard (no threshold derived)) -
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.38 mg/kg bw/day effect on fertility
Acute /short term: (DNEL) 1.38 mg/kg bw/day effect on fertility
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 1 1 2
Supporting study 5 4
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 1 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 12 studies submitted
  • 3 studies processed
P/RResults
LD50 10 mL/kg bw (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 3
Supporting study 9
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
dermal
  • 9 studies submitted
  • 3 studies processed
P/RResults
LD50 10 mL/kg bw (rat) [3]
M/CInterpretations of results
GHS criteria not met [1]

dermal
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 5 740 mg/kg bw
Dermal route:
No adverse effect observed LD50 5 740 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 10 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 3
Supporting study 6
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 10 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 500 mg/kg bw/day [1]

Type of Study provided
Study data: oral
Studies with data
Key study 1 1 2
Supporting study 3
Weight of evidence 3
Other
Data waiving
no waivers
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route - systemic effects:
No adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 6 4
Supporting study 3
Weight of evidence 1
Other
Data waiving
no waivers
Study data: in vivo
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed NOAEL 500 mg/kg bw/day (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1 1 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: developmental
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 2 1 2
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 1 summary processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 292 mg/kg bw/day (subchronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant