Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

  • EC / List name: Aluminium sulphate
  • IUPAC name: dialuminium(3+) trisulfate
  • Other names
EC / List no.:
233-135-0
CAS no.:
10043-01-3
Index number:
Molecular formula:
Al2O12S3
SMILES:
[Al+3].[Al+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O
InChI:
InChI=1S/2Al.3H2O4S/c;;3*1-5(2,3)4/h;;3*(H2,1,2,3,4)/q2*+3;;;/p-6
Type of substance:
Mono constituent substance
Origin:
Inorganic
Registered compositions:
62
Of which contain:
12 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the classification provided by companies to ECHA in REACH registrations this substance causes severe skin burns and eye damage, causes serious eye damage and may be corrosive to metals.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if swallowed.

Breakdown of all 1084 C&L notifications submitted to ECHA

Eye Dam. 1 H318
Met. Corr. 1 H290
Acute Tox. 4 H302
Not Classified
Eye Irrit. 2 H319
Aquatic Chronic 3 H412
Aquatic Chronic 2 H411
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
STOT SE 3 H335
Skin Irrit. 2 H315
Skin Corr. 1A H314
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 104 active registrations under REACH, 1 Joint Submission(s) and 2 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 100 000 - 1 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: pH regulators and water treatment products, water treatment chemicals, fertilisers, washing & cleaning products and cosmetics and personal care products.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: hot work operations with metals (e.g. welding, soldering, gouging, brazing, flame cutting), the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), closed, continuous processes with occasional controlled exposure, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and open transfer and processing with minerals/metals at elevated temperature.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates) and industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use as reactive substance and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).

This substance can be found in products with material based on: leather (e.g. gloves, shoes, purses, furniture), plastic (e.g. food packaging and storage, toys, mobile phones) and stone, plaster, cement, glass or ceramic (e.g. dishes, pots/pans, food storage containers, construction and isolation material).

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products, paper chemicals and dyes, textile treatment products and dyes, leather treatment products, coating products, water treatment chemicals and washing & cleaning products.

This substance is used in the following areas: printing and recorded media reproduction, agriculture, forestry and fishing, mining, building & construction work and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: pulp, paper and paper products, textile, leather or fur, chemicals and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, transfer of substance into small containers, mixing in open batch processes, hand mixing with intimate contact only with personal protective equipment available, laboratory work, batch processing in synthesis or formulation with opportunity for exposure and closed processes with no likelihood of exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products, paper chemicals and dyes, water treatment chemicals, textile treatment products and dyes, leather treatment products, coating products and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, hand mixing with intimate contact only with personal protective equipment available, laboratory work and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid and formulation in materials. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: laboratory chemicals, pH regulators and water treatment products, paper chemicals and dyes, leather treatment products, textile treatment products and dyes, coating products, washing & cleaning products and water treatment chemicals.

This substance is used in the following areas: printing and recorded media reproduction, mining, agriculture, forestry and fishing, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and building & construction work. This substance is used for the manufacture of: pulp, paper and paper products, textile, leather or fur and chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, laboratory work, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes, hand mixing with intimate contact only with personal protective equipment available and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, closed processes with no likelihood of exposure, laboratory work and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, formulation of mixtures, in processing aids at industrial sites, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates). Other release to the environment of this substance is likely to occur from: indoor use as processing aid.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

If medical advice is needed, have product container or label at hand. Read label before use. Keep out of reach of children.

Prevention statements

When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Response statements

In case of incident: Rinse cautiously with water for several minutes. If in contact with eyes, remove contact lenses if present and easy to do - continue rinsing. If in eyes: follow instructions specified by manufacturer/supplier. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Immediately call a poison center or doctor/physician.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • AB Achema, Jonalaukio km. Ruklos sen. LT55550 Jonavos r. Lithuania
  • Acme Italiana, Regione Vergini 55/56 15010 Rivalta Bormida (AL) Italy
  • Acorn Water Ltd, Glasslyn Road NNNNN Bandon Co. Cork Ireland
  • Alfafarm, Strandvejen 195 5500 Middelfart Denmark
  • Aliada Quimica de Portugal Lda., Quinta da Industria - Beduido PT-3860 Estarreja Portugal
  • ALKO SAS, 1046 route de Chaumontet BP 501 FR-74330 Poisy France
  • ALSAL PROD S.R.L., Strada George Enescu nr.16, ap.2 410034 Oradea Bihor Romania
  • ALUCOM AG, Giulinistraße 2 D-67065 Ludwigshafen Germany
  • Amik Italia, VIA MECENATE 84B 20138 MILANO Italy Italy
  • Aquacenic Iberica SL, Av de la Cassola, 6 46500 Sagunto Valencia Spain
  • B-Lands Consulting (811647-3), World Trade Center, 5 Place Robert Schuman - BP 1516 38025 Grenoble France France
  • BASF Construction Chemicals Italia Spa, Viale Vittorio Veneto, 3 Casella Postale 278 31100 Treviso Italy
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BIO-LINE CHEMICALS SRL, Via Curioni 3 26832 Galgagnano (LO) Italy
  • Cambridge Environmental Assessments part of RSK ADAS Europe (Ireland) Ltd (HIC), Office Suite B, Bluebell Business Centre, Old Naas Road, D12X V7K Dublin, Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemifloc Limited, Smithstown Industrial Estate 0 Shannon Co. Clare Ireland
  • CHEMOS GmbH, Sonnenring 7 84032 Altdorf Germany
  • Chemreach GmbH, Akazienweg 30 48317 Drensteinfurt Germany
  • CHIMICA Dr. FR. D'AGOSTINO S.p.A., Via G. Murari, 3 (Z.I.) 70132 Bari Italy - IT Italy
  • CHIMIGIEN S.r.l., Via Levrini 2 25080 Soiano Del Lago (BS) Italy
  • Clinty Chemicals Limited, 215 Doury Road BT43 6SS Ballymena Co. Antrim United Kingdom
  • Colombus Group s.r.o., Ciruvkova 172/32 10400 Prague Czech Republic
  • Continvest ltd, 6 Hubavka str. 1111 Sofia Sofia Bulgaria
  • Croda Denmark A/S, Elsenbakken 23 3600 Frederikssund Denmark
  • DEKITRA S.A., Ctra. Miranda de Ebro a Puentelarrá km.5 Pol. Ind. Lantarón 01213 LANTARON Alava Spain
  • DEQUACHIM, Route de Wallonie 1 7011 Ghlin Belgium
  • Dimensa, Damian Diaz Sanchez S.L., Carretera del Pilar 06173 Nogales Badajoz Spain
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • EcoloChem GmbH, Bahnhofstrasse 10. DE-08134 Langenweißbach Germany
  • EcoloChem Magyaróvár Kft., Timföldgyari u. 13.B.ep 9200 Mosonmagyaróvár Hungary
  • EcoMole s.r.o., U Větrníku 40/1 162 00 Prague 6 Czech Republic
  • ELDON'S AEBE, 20 Souliou Street 143 43 N. Halkidona Athens Greece
  • Evonik Nutrition & Care GmbH, Rellinghauser Strasse 1-11 45128 Essen Germany
  • Feralco (UK) Ltd, Ditton Road WA8 0PH Widnes United Kingdom
  • Feralco Deutschland GmbH, Gr. Drakenburger Str. 93-97 DE-31582 NIenburg/Weser Germany
  • Feralco Environnement SAS, 158 Ave. de Stalingrad, Bat 6 FR-92712 Colombes France
  • Feralco Iberia SAU, Erbeta 3-5 ES-20260 Alegia, Gipuzkoa Spain
  • Feralco Italia Srl, Via L. da Vinci 3/7 IT-57123 Livorno Italy
  • Feralco Nederland BV, Westkade 38a NL-4551 BV Sas van Gent Netherlands
  • FujiFilm Manufacturing Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Galcon GmbH, Oberreutiner Weg 13d 88131 Lindau am Bodensee Germany
  • GCP Produits de Construction S.A.S OR5, Za Les Foulletons 39140 Larnaud France
  • GRACE GmbH, In der Hollerhecke 1 67545 Worms Germany
  • GRACE Silica GmbH, Kreuzauer Str. 46 52355 Düren Germany
  • Haldor Topsoe A/S, Nymøllevej 50 DK28000 Lyngby Denmark
  • Hasbro International Holdings BV, De Entree 240 1011EE Amsterdam Netherlands
  • ICL Europe Coöperatief U.A., Prinsenhof Building Koningin Wilhelminaplein 30 1062 KR Amsterdam NH Netherlands
  • Industrial Chemicals Limited, Titan Works Hogg Lane RM17 5DU Grays Essex United Kingdom
  • Industrias Quimicas del Ebro, Poligono Malpica Calle D 97 50016 Zaragoza Spain
  • International Paper Kwidzyn Sp. z o. o., Lotnicza 1 PL 82-500 Kwidzyn Pomorskie Poland
  • ITALCHEMICAL INDUSTRIALE S.R.L., VIA consortile n.18/20 03013 FERENTINO (FR) Italy
  • Kemipol Sp. Z o.o., ul. Kuznicka 6 PL-72010 Police Poland
  • Kemira Chemicals (UK) Ltd, Bowling Park Drive UK-BD4 7TT Bradford West Yorkshire United Kingdom
  • Kemira Chemicals AS, Oraveien 14 1631 Gamle Fredrikstad Norway
  • Kemira Chimie S.A.S.U., Route de Mothern, Zone Portuaire FR-67630 LAUTERBOURG France
  • Kemira Germany GmbH, Marie-Curie-Strasse 10 Innovationspark D-51377 Leverkusen Germany
  • Kemira Ibérica S.A., Gran Via Corts Catalanes 641 ES-08010 BARCELONA Spain
  • KEMIRA ITALY S.P.A, Via E. Majorana 8 33058 San Giorgio di Nogaro (UD) Italy
  • Kemira Kemi AB, Industrigatan 83 SE-25109 HELSINGBORG Sweden
  • Kemira KTM d.o.o., OB Zelznici 14 1000 LJUBLJANA Slovenia
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • Kemira Rotterdam B.V., Botlekweg 175 (Harbour number 4501) P.O. Box 5020 NL-3197 XE Botlek-Rotterdam Netherlands
  • Kemwater ProChemie s.r.o., úpravna vody Bradlec č.p. 253 CZ-29306 Kosmonosy Czech Republic
  • Koenig Metallveredelung GmbH, Industriestr. 1 79787 Lauchringen Germany
  • KRONOS TITAN AS, Titangaten 1 1630 Gamle Fredrikstad Norway
  • LUBRICO - A.TSAKALIS Ltd, 10 Km Elefsinas - Dervenoxorion 19018 Magoula Greece
  • MASNATA CHIMICI S.p.A., Via della Rinascita, n. 7 09030 ELMAS (CA) Italy
  • Merck KGaA, Frankfurter Strasse 64293 Darmstadt Germany
  • Metal Finish SpA, Via Cerioli, 71 24068 Seriate (Bergamo) Lombardia Italy
  • Mondi Swiecie S.A., Bydgoska1 86-100 Swiecie Kujawsko-Pomorskie Poland
  • Nippon Shokubai Europe N.V., Haven 1053 B-2070 Nieuwe Weg 1 Zwijndrecht Belgium
  • Nord Chemical Products s.r.l., Via Papa Giovanni XXIII, 94/D 24121 Bergamo Italy
  • OSTCHEM Germany GmbH S, Erdmannstr. 10 22765 Hamburg Germany
  • Precheza a.s. Přerov, Nábřeží Dr. E. Beneše 24 751 62 Přerov Czech Republic
  • PRODUCTOS ALBI SL, Pl. Soler Carbonell, 28, planta 2, local 4, edif. El Llorer 08800 VILANOVA I LA GELTRU BARCELONA Spain
  • QUÍMICA DEL CINCA, S.L., Avda. Diagonal 352 08013 Barcelona Barcelona Spain
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • Samar s.r.l. Società Unipersonale, Via Miranese 5 30171 VENEZIA-MESTRE VE Italy
  • SAPEC QUIMICA, S.A., Parque Industrial "SAPEC Bay", Av. do Rio Tejo 2901-952 Setúbal Portugal
  • SATMA PPC, 2 ZA La Chandelière 38570 GONCELIN France
  • SC Kemcristal SRL, 51, Muncii Street RO-915200 Fundulea City Calarasi County Romania
  • SC POP INDUSTRY SRL, Cireasov no 34 230070 Slatina Olt Romania
  • Secam srl, Via Vicoli 93/A 48124 Ravenna Italy
  • SEICA SRL, Via Pietramarina n. 42/a 50059 Vinci Firenze Italy
  • SIA "METACHEM-Baltic", Ģenerāļa Baloža iela 31 3414 Liepāja Latvia
  • Société Française SOQUEBRA S.A., 7, rue Blaise Pascal 74600 SEYNOD France
  • TANAC S.A. (represented by Luxcontrol S.A.), 1, Avenue des Terres Rouges BP 349 4004 Esch-sur-Alzette Luxembourg
  • TDK FOIL ITALY SPA, Via E.C.H. Rosenthal 5 20089 Rozzano Italy
  • Tronox Pigment UK Limited, PO Box 26 LaPorte Road, Stallingborough DN41 8DP Grimsby Northeast Lincolnshire United Kingdom
  • UMCO GmbH, Georg-Wilhelm-Straße 187 21107 Hamburg Germany
  • Venator France SAS, 1 Rue des Garennes 62100 Calais France
  • Venator Germany GmbH, Dr.- Rudolf-Sachtleben Str. 4 47198 Duisburg Germany
  • Venator Germany GmbH - OR1, Dr.- Rudolf-Sachtleben Str. 4 47198 Duisburg Germany
  • VENATOR ITALY S.R.L., Localita Casone 1 58020 Scarlino GR Italy
  • VENATOR MATERIALS UK LIMITED, Titanium House Hanzard Drive TS22 5FD Wynyard Park United Kingdom
  • VENATOR MATERIALS UK LIMITED - OR2, Titanium House Hanzard Drive TS22 5FD Wynyard Park United Kingdom
  • Venator P&A Finland Oy, Titaanitie 28840 Pori Finland
  • Venator P&A Spain S.L., Poligono Industrial Nuevo Puerto Calle A s/n 21810 Palos de la Frontera (Huelva) Spain
  • Venator Uerdingen GmbH, Rheinuferstraße 7–9 47829 Krefeld Germany
  • Water Utility Chemicals Ltd, Unit 2 Suttons Quays Business Park Clifton Road WA7 3EH Runcorn Cheshire United Kingdom
  • Wibax AB, Batterigatan 12 SE-941 47 Piteå Norrbotten Sweden
  • Zeolyst CV, Oosterhorn 36 9936 HD1 Delfzijl Netherlands
  • Compact Consultants Ltd, 123 Oborishte Street 123 Oborishte Street 1505 Sofia Bulgaria Bulgaria
  • DIAMO, s.p., Máchova 201 47127 Stráž pod Ralskem Czech Republic
  • LEAF GROUP Ltd, 59 Lui Ayer Street 59 Lui Ayer Street 1404 Sofia Bulgaria Bulgaria
  • OSTCHEM Germany GmbH, Erdmannstr. 10 22765 Hamburg Germany
  • SC CESAL SA, Calea Borsului 31C 410605 Oradea Bihor Romania

Other names

  • -
  • alluminio solfato
  • Aluminium Sulfate
  • Aluminium sulfate (2:3)
  • Aluminium sulfate octadecahydrate
  • ALUMINIUM SULPHATE
  • Aluminium sulphate hydrated
  • Aluminium sulphate in acqueous acid solution
  • Aluminium sulphate liquid
  • aluminum potassium disulfate
  • ALUMINUM SULFATE
  • Aluminum sulphate
  • Benzene, 1-bromo-3-chloro-5-(difluoromethoxy)-
  • dialuminium trisulphate
  • dialuminium(3+) trisulfate
  • dialuminum trisulfate
  • dialuminum;trisulfate
  • Sulfat de Aluminiu
  • SULFATO DE ALUMINIO
  • Sulfuric acid, aluminum salt
  •   aluminium sulphate
  • Aluminium sulphate
  • ALS
  • ALS 41
  • ALS 45
  • ALUM
  • Aluminium Sulfate
  • Aluminium sulphate
  • Aluminium sulphate, Solid
  • Aluminium Trisulfate
  • Aluminiumsulfat
  • Cake alum
  • Delta Floc A-III
  • Filter alum
  • Gecedral AS
  • Liquid Acid Aluminium Sulphate 7,3%
  • Liquid Aluminium Sulphate 8,2%
  • Not traded off the registering site
  • Papermaker's alum
  • Solfato di alluminio
  • SUFAL 17.0
  • SUFAL 8.2
  • Sulfato de aluminio
  • Sulfuric acid, aluminum salt (3:2)
  • Síran hlinitý
  • Technical Purified Aluminium Sulphate

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 7 studies submitted
  • 5 studies processed
C Physical state at 20°C and 1013 hPa
Solid (80%), Liquid (20%) [5]
C Form
Crystalline (43%), Other (29%), Pellets (14%), Powder (14%) [7]
C Odour
Odourless (60%), Slight (20%), Other (20%) [5]
C Substance type
Inorganic (100%) [5]

Type of Study provided
Studies with data
Key study 1 4
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 4 summaries submitted
  • 4 summaries processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 13 studies submitted
  • 4 studies processed
R Melting / freezing point
349.84 - 770 °C @ 0 - 101 325 Pa [4]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence 1
Other 6
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
349.84 - 450 °C

Boiling point

Study results
  • 4 studies submitted
  • 1 study processed
R Boiling point
806.45 °C @ 0 Pa [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Boiling point at 101 325 Pa
798.27 - 806.45 °C

Density

Study results
  • 14 studies submitted
  • 7 studies processed
R Density
2.71 g/cm³ @ 20 °C [5]
R Relative density
1.61 - 2.71 @ 17 °C [3]

Type of Study provided
Studies with data
Key study 4 3
Supporting study 1
Weight of evidence
Other 6
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Relative density at 20°C
2.71 - 2 710

Vapour pressure

Study results
  • 5 studies submitted
  • 1 study processed
R Vapour pressure
0 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
Vapour pressure
0 - 0.001 Pa @ 20 - 25 °C

Partition coefficient

Study results
  • 5 studies submitted
  • 1 study processed
R Log Pow
-5.075 @ 25 °C and pH 7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
-5.08 - -0.12 @ 20 °C

Water solubility

Study results
  • 14 studies submitted
  • 8 studies processed
R Water solubility (mass/vol.)
12 - 1 000 000 000 µg/L @ 0 - 25 °C and pH 1.9 - 7 [9]

Type of Study provided
Studies with data
Key study 4
Supporting study 1
Weight of evidence 2 5
Other 1 1
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Water solubility
3.12 g/L @ 0 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 2 studies processed
R Standard fat
0.01 ng/L @ 20 °C [2]
R Ethanol
0.001 ng/L @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Solubility in mg/100g standard fat at 20 °C
0
Solubility in organic solvents at 20 °C
0.001 ng/L

Surface tension

Study results
  • 5 studies submitted
  • 3 studies processed
R Surface tension
73 - 105 mN/m @ 100 - 1 000 mg/L and 20 - 26 °C [3]

Type of Study provided
Studies with data
Key study 2 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
105 mN/m @ 100 mg/L

Flash point

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Auto flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 7 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 4 studies submitted
  • 1 study processed
C Interpretation of results
Non-explosive (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Oxidising
No (100%)

Oxidation reduction potential

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

pH

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 4 studies submitted
  • 2 studies processed
C Dissociating properties
Yes (100%) [2]
R Dissociation constant
3.3 - 3.6 @ 20 °C [2]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
pKa at 20 °C
3.6

Viscosity

Study results
  • 5 studies submitted
  • 2 studies processed
R dynamic viscosity (in mPa s)
17 [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Dynamic viscosity at 20 °C
17 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 3 studies submitted
  • 1 study processed
R Degradation rate constant (OH radicals)
0 cm³ molecule-1 d-1 [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 1 summary processed
Half life in air
76.4 days
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Half-life for hydrolysis
60 - 10 080 min @ 25 °C

Phototransformation in water

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
362 L/kg ww

Bioaccumulation: terrestrial

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
0.893 - 3.162 L/kg ww

Adsorption/desorption

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 2
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Koc at 20°C
31.82 - 75.41

Henrys law constant (H)

Study results
  • 2 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
0 Pa m³/mol @ 25 °C and 101.325 kPa [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Henry's law constant
0 Pa.m³.mol-1 @ 25 °C

Distribution modelling

Study results
  • 2 studies submitted
  • 1 study processed
% Distribution in Media:
R Air 0 % [1]
R Water 18.8 % [1]
R Soil 81.1 % [1]
R Sediment 0.104 % [1]
R Suspended sediment 0 % [1]
R Biota 0 % [1]
R Aerosol 0 % [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 4 summaries submitted
  • 4 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 300 - 4 500 000 ng/L (3)
Intermittent releases (freshwater) 30.11 mg/L (2)
Marine water 30 - 64 000 000 ng/L (3)
Intermittent releases (marine water) No hazard identified (1)
Sewage treatment plant (STP) 20 - 60.2 mg/L (3)
Sediment (freshwater) 10 mg/kg sediment dw (2)
Sediment (marine water) 31.4 mg/kg sediment dw (2)
Hazard for Air
Air 2 mg/m³ (1)
Hazard for Terrestrial Organism
Soil 58 mg/kg soil dw (2)
Hazard for Predators
Secondary poisoning 150 mg/kg food (2)

Short–term toxicity to fish

Study results
  • 34 studies submitted
  • 30 studies processed
P/RResults
LC50 (8 days) 122.17 - 161.4 mg/L [4]
LC50 (7 days) 430 - 4 270 µg/L [8]
LC50 (6 days) 560 - 6 650 µg/L [14]
LC50 (5.833 days) 22.74 mg/L [2]
LC50 (5 days) 1.05 - 20.8 mg/L [18]

Type of Study provided
Studies with data
Key study 24 2
Supporting study 3 1
Weight of evidence 3 1
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
122.17 mg/L
LC50 for marine water fish
12.2 mg/L

Long–term toxicity to fish

Study results
  • 45 studies submitted
  • 41 studies processed
P/RResults
NOEC (60 days) 13 - 1 670 µg/L [37]
NOEC (33 days) 71.5 - 558.1 µg/L [7]
NOEC (30 days) 250 - 1 670 µg/L [24]
NOEC (28 days) 29.8 - 44.9 mg/L [6]
NOEC (15 days) 1.67 mg/L [6]

Type of Study provided
Studies with data
Key study 27
Supporting study 1
Weight of evidence 16
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater fish
44.9 mg/L
EC10 / LC10 or NOEC for marine water fish
4.5 mg/L

Short–term toxicity to aquatic invertebrates

Study results
  • 55 studies submitted
  • 45 studies processed
P/RResults
EC50 (4 days) 5.9 - 58.2 mg/L [8]
EC50 (72 h) 27.7 mg/L [2]
EC50 (48 h) 1.4 - 200 mg/L [11]
LC50 (7 days) 11.2 mg/L [2]
LC50 (72 h) 1.52 - 19.5 mg/L [6]

Type of Study provided
Studies with data
Key study 35 6
Supporting study 7 1
Weight of evidence 4
Other 2
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
242 mg/L
EC50 / LC50 for marine invertebrates
19.5 mg/L

Long–term toxicity to aquatic invertebrates

Study results
  • 17 studies submitted
  • 9 studies processed
P/RResults
NOEC (42 days) 232.6 - 453.8 µg/L [4]
NOEC (30 days) 1.092 - 2.099 mg/L [2]
NOEC (28 days) 53.1 - 12 000 µg/L [6]
NOEC (17 days) 962.5 µg/L [1]
NOEC (10 days) 1.1 - 4.282 mg/L [2]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 4 2
Weight of evidence 6
Other 1
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC10 / LC10 or NOEC for freshwater invertebrates
12 mg/L
EC10 / LC10 or NOEC for marine invertebrates
1.2 mg/L

Toxicity to aquatic algae and cyanobacteria

Study results
  • 28 studies submitted
  • 15 studies processed
P/RResults
EC50 (30 days) 1.767 g/L [2]
EC50 (5 days) 3.011 - 19.091 g/L [4]
EC50 (4 days) 460 - 570 µg/L [2]
EC50 (72 h) 40 - 100 000 µg/L [10]
EC50 (22 h) 25 mg/L [2]

Type of Study provided
Studies with data
Key study 12 2
Supporting study 9 1
Weight of evidence 1 1
Other 2
Data waiving
no waivers
R Summaries
  • 4 summaries submitted
  • 2 summaries processed
EC50 for freshwater algae
3.011 g/L
EC50 for marine water algae
302 mg/L
EC10 or NOEC for freshwater algae
602 mg/L
EC10 or NOEC for marine water algae
30 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 11 studies submitted
  • 10 studies processed
P/RResults
EC50 (42 days) 171.07 g/L [4]
EC50 (35 days) 171.07 g/L [4]
EC50 (22 days) 114 - 512 µg/L [4]
EC50 (7 days) 8.643 - 15.966 mg/L [3]
EC50 (24 h) 6 mg/L [2]

Type of Study provided
Studies with data
Key study 6
Supporting study 1
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC50 for freshwater plants
171.07 g/L
EC50 for marine water plants
17.107 g/L
EC10 or NOEC for freshwater plants
34.214 g/L
EC10 or NOEC for marine water plants
1.711 g/L

Toxicity to microorganisms

Study results
  • 14 studies submitted
  • 9 studies processed
P/RResults
EC50 (1.084 years) 500 - 3 100 µg/L [2]
EC50 (22 days) 114 - 512 µg/L [2]
EC50 (5 days) 3.011 - 19.091 g/L [4]
EC50 (24 h) 6 mg/L [2]
EC50 (3 h) 200 - 1 000 mg/L [2]

Type of Study provided
Studies with data
Key study 8
Supporting study 4 1
Weight of evidence 1
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 3 summaries processed
EC50 for microorganisms
3.011 g/L
EC10 or NOEC for microorganisms
200 - 602 mg/L

Sediment toxicity

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
NOEC (4 days) 100 mg/kg sediment dw [2]
NOEC (24 h) 31.4 mg/kg sediment dw [2]
EC50 (1.501 years) 2 000 mg/kg sediment dw [2]
EC50 (10 days) 1 - 1.1 mg/L [2]
EC50 (24 h) 157.384 mg/kg sediment dw [2]

Type of Study provided
Studies with data
Key study 8
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater sediment
500 mg/kg sediment dw
EC50 / LC50 for marine water sediment
157 mg/kg sediment dw
EC10 / LC10 or NOEC for freshwater sediment
100 mg/kg sediment dw
EC10 / LC10 or NOEC for marine water sediment
31.4 mg/kg sediment dw

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 5 studies processed
P/RResults
NOEC (42 days) 100 mg/kg soil dw [3]
LOEC (8 days) 10 - 320 mg/kg soil dw [6]
LOEC (4 days) 10 - 1 000 mg/kg soil dw [6]
EC50 (18 days) 197 - 883 mg/kg soil dw [3]
LC50 (21 days) 589 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 5
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
64.4 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
21 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
NOEC (55 days) 12.6 mg/kg soil dw [2]
LC50 (55 days) 63 - 6 077 mg/kg soil dw [2]
LC50 (4 days) 506 - 6 077 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 4
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
506 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
12.6 mg/kg soil dw

Toxicity to terrestrial plants

Study results
  • 14 studies submitted
  • 6 studies processed
P/RResults
NOEC (80 days) 6.1 - 19.1 mg/kg soil dw [4]
NOEC (9 days) 108.3 mg/kg soil dw [2]
LOEC (9 days) 43.3 mg/kg soil dw [2]
EC50 (9 days) 542 mg/kg soil dw [2]
EC50 (30 min) 171.075 g/kg soil dw [2]

Type of Study provided
Studies with data
Key study 11
Supporting study
Weight of evidence 1
Other 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
542 mg/kg soil dw
Long-term EC10 / LC10 / NOEC
127 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 11 studies submitted
  • 8 studies processed
P/RResults
EC50 (30 days) 10 - 4 000 mg/kg soil dw [2]
EC50 (28 days) 220 µg/kg soil dw [2]
EC50 (4 days) 10 - 100 mg/kg soil dw [4]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50
2 g/kg soil dw
Long-term EC10 / NOEC
579 mg/kg soil dw

Toxicity to birds

Study results
  • 11 studies submitted
  • 8 studies processed
P/RResults
NOEL (4 months) 125 mg/kg bw/day [2]
NOEL (63 days) 500 - 1 500 mg/kg bw/day [6]
NOEL (56 days) 375 mg/kg bw/day [2]
NOEL (42 days) 375 mg/kg bw/day [2]
NOEL (28 days) 62.5 - 375 mg/kg bw/day [14]

Type of Study provided
Studies with data
Key study 10
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
5 g/kg food
Long-term EC10 / LC10 / NOEC
1.5 g/kg food

Toxicity to mammals

Study results
  • 10 studies submitted
  • 8 studies processed
P/RResults
NOEC (14 days) 1 000 mg/kg diet [2]
EC50 (1.501 years) 2 000 mg/kg diet [2]
EC50 (7.083 days) 0.051 - 513.21 mg/kg diet [6]
LC100 (60 min) 15 mg/kg diet [2]

Type of Study provided
Studies with data
Key study 6 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Short-term EC50 / LC50
5 g/kg food
Long-term EC10 / LC10 / NOEC
400 mg/kg food

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 3 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 3 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 2 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.71 mg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 46.7 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 882 µg/cm² repeated dose toxicity
Acute /short term: (DNEL) 882 µg/cm² repeated dose toxicity
EYE Exposure
Medium hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.5 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 mg/m³ acute toxicity
Local Effects
Long-term: (DNEL) 1.5 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 1 mg/m³ acute toxicity
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 855 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 23.35 mg/kg bw/day acute toxicity
Local Effects
Long-term: (DNEL) 441 µg/cm² repeated dose toxicity
Acute /short term: (DNEL) 441 µg/cm² acute toxicity
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.9 mg/kg bw/day neurotoxicity
Acute /short term: (DNEL) 92.4 mg/kg bw/day acute toxicity
EYE Exposure
Medium hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 23 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 16
Supporting study 2 1
Weight of evidence 1
Other 3
Data waiving
no waivers
Study data: dermal absorption
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1 6
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 0.21 %
Dermal: 1 %
Inhalation: 1 %

Acute toxicity

Study results
oral
  • 15 studies submitted
  • 11 studies processed
P/RResults
LD50 2 000 - 5 000 mg/kg bw (rat) [8]
LD50 253 - 6 200 mg/kg bw (mouse) [6]
M/CInterpretations of results
Study cannot be used for classification [2]

Type of Study provided
oral
Studies with data
Key study 6 4
Supporting study 1
Weight of evidence 1
Other 1 2
Data waiving
no waivers
inhalation
  • 12 studies submitted
  • 12 studies processed
P/RResults
LC50 (5 days) 50 - 200 mg/m³ air (rat) [2]
LC50 (4 h) 5 - 5.09 mg/L air (rat) [2]
Discriminating conc. (1 min) 20 ppm (rat) [2]
M/CInterpretations of results
Sligthly toxic [6]

inhalation
Studies with data
Key study 4 6
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
dermal
  • 9 studies submitted
  • 9 studies processed
P/RResults
LD50 1 167.5 mg/kg bw (mouse) [1]
LD50 1 167.5 mg/kg bw (pig) [1]
LD50 1 167.5 - 5 000 mg/kg bw (rabbit) [4]
M/CInterpretations of results
Practically nontoxic [5]

dermal
Studies with data
Key study 7 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 5 mg/kg bw (rat) [2]

other routes
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 2
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 50 mg/m³
Dermal route:
No adverse effect observed LD50 1 167.5 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 18 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 4 5
Supporting study 6
Weight of evidence 2 1
Other
Data waiving
no waivers
Study data: eye
  • 13 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 4 6
Supporting study 2
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 3 3
Supporting study 1
Weight of evidence 1
Other
Data waiving
no waivers
Study data: respiratory
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 3 summaries submitted
  • 3 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
Adverse effect observed (sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 26 studies submitted
  • 14 studies processed
P/RResults
rat (LD50): 1 167.5 mg/kg bw [5]
NOAEL (rat): 100 - 1 000 mg/kg bw/day [8]
LOAEL (rat): 108 - 544 mg/kg bw/day [10]

Type of Study provided
Study data: oral
Studies with data
Key study 6 3
Supporting study 2
Weight of evidence 1 4
Other 4 6
Data waiving
no waivers
Study data: inhalation
  • 10 studies submitted
  • 4 studies processed
P/RResults
NOAEL (rat): 1.3 - 2.45 mg/m³ air [4]
LOAEL (rat): 5.9 mg/m³ air [2]

Study data: inhalation
Studies with data
Key study 7
Supporting study
Weight of evidence 1
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Study data: dermal
  • 6 studies submitted
  • 1 study processed
P/RResults
NOAEL (mouse): 0.79 - 3.17 mg/kg bw (total dose) [3]
LOAEL (mouse): 12.66 mg/kg bw (total dose) [1]

Study data: dermal
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other 1 1
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 3 summaries submitted
  • 2 summaries processed
Oral route - systemic effects:
No adverse effect observed NOAEL 342 mg/kg bw/day (subchronic, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 8.55 mg/kg bw/day (subchronic, rat)
Dermal route - local effects:
No adverse effect observed NOAEL 4.41 mg/cm² (subacute, rabbit)
Inhalation route - systemic effects:
No adverse effect observed NOAEC 15 mg/m³ (chronic, rat)
Inhalation route - local effects:
No adverse effect observed NOAEC 15 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 70 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 32 2
Supporting study 9
Weight of evidence 3 1
Other 7 16
Data waiving
no waivers
Study data: in vivo
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 10 4
Supporting study 8
Weight of evidence 1
Other 3 11
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 20 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 9
Supporting study 4
Weight of evidence 6
Other 1
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 2 summaries processed
Oral route:
No adverse effect observed NOAEL 850 mg/kg bw/day (chronic, mouse)
Dermal route:
No adverse effect observed NOAEL 6.8 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 6.1 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 50 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 8 16
Supporting study 1 7
Weight of evidence
Other 4 14
Data waiving
no waivers
Study data: developmental
  • 62 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 8 6
Supporting study 2 5
Weight of evidence
Other 11 30
Data waiving
no waivers
Study data: other studies
  • 7 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study 4
Supporting study
Weight of evidence
Other 1 2
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Effect on fertility
Oral route:
No adverse effect observed NOAEL 5.41 mg/kg bw/day (subchronic, rat)
Dermal route:
No adverse effect observed NOAEL 2.48 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 38.6 mg/m³ (chronic, rat)
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 93 mg/kg bw/day (chronic, rat)
Dermal route:
No adverse effect observed LOAEL 2.21 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed LOAEC 12 mg/m³ (chronic, mouse)

Neurotoxicity

Study results
  • 57 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 16 7
Supporting study
Weight of evidence
Other 6 28
Data waiving
no waivers
M/C Summaries
  • 5 summaries submitted
  • 4 summaries processed
Oral route:
No adverse effect observed NOAEL 93 mg/kg bw/day (chronic, rat)
Dermal route:
No adverse effect observed LOAEL 4.75 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 38.6 mg/m³ (chronic, rat)

Immunotoxicity

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 8 4
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Oral route:
No adverse effect observed LOAEL 300 mg/kg bw/day (chronic, mouse)
Dermal route:
No adverse effect observed LOAEL 2.4 mg/kg bw/day (chronic, mouse)
Inhalation route:
No adverse effect observed NOAEC 3.8 mg/m³ (chronic, rat)

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant